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Bacterial Porins and Their Implication in Pathophysiology of Septic Complications...
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Department of Medicine, AFO Medicine Interna, PO Santa Maria delle Grazie Hospital, ASL Napoli 2 Nord, 80078 Napoli, Italy
Emerging Infectious Disease at High Countagiousness, AORN Ospedali dei Colli—P.O. D.Cotugno, 80131 Naples, Italy
Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy
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Bacterial Porins and Their Implication in Pathophysiology of Septic Complications In Vitro and In Vivo

Abstract submission deadline
closed (30 November 2024)
Manuscript submission deadline
31 January 2025
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2152

Topic Information

Dear Colleagues,

Bacterial porins control cellular interactions with host proteins and other circulating substances, such as drugs and nutrients. They may act as toxins, damaging different systems and organs in the host. For this reason, they play a fundamental role in the processes involved in drug resistance and bacterial-induced complications, such as thrombosis, bleeding, and septic shock. Our in vitro experience in the early 2000s showed that bacterial porin from salmonella is able to activate the clotting cascade with the direct activation of thrombin, explaining its frequent association with thrombosis and disseminated intravascular coagulation. Furthermore, resistance towards drugs other than antibiotics may also explain other types of complications, such as kidney or liver failure. Therefore, this multidisciplinary topic of Toxins is directed to scholars that are experts not only in the field of bacterial porins, but also in the clinical spectrum of their induced complications, such as septic shock, disseminated intravascular coagulation, thrombosis of small or large vessels, and kidney or liver failure.

Dr. Pierpaolo Di Micco
Dr. Alessandro Perrella
Dr. Olga Scudiero
Topic Editors

Keywords

  • porins
  • LPS
  • antibiotic resistance
  • antibiotic stewardship
  • septic shock
  • disseminated intravascular coagulation
  • liver toxicology
  • kidney dysfunction
  • clotting abnormalities

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Antibiotics
antibiotics 		4.3 7.3 2012 14.7 Days CHF 2900 Submit
Applied Microbiology
applmicrobiol 		- - 2021 16.3 Days CHF 1000 Submit
Immuno
immuno 		2.1 2.6 2021 28.1 Days CHF 1000 Submit
Medicina
medicina 		2.4 3.3 1920 17.8 Days CHF 2200 Submit
Toxins
toxins 		3.9 7.5 2009 18.9 Days CHF 2700 Submit

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Published Papers (1 paper)

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Review
Bacterial Porins and Their Procoagulant Role: Implication in the Pathophysiology of Several Thrombotic Complications during Sepsis
by Carmine Siniscalchi, Alessandro Perrella, Ugo Trama, Francesca Futura Bernardi, Egidio Imbalzano, Giuseppe Camporese, Vincenzo Russo, Olga Scudiero, Tiziana Meschi and Pierpaolo Di Micco
Toxins 2024, 16(8), 368; https://doi.org/10.3390/toxins16080368 - 20 Aug 2024
Viewed by 951
Abstract
The association between sepsis and thrombotic complications is still not well known. Different mechanisms have been shown to be involved in the sepsis-induced prothrombotic state, but clinical scenarios may differ. In this review, we have summarized the role that bacterial products such as [...] Read more.
The association between sepsis and thrombotic complications is still not well known. Different mechanisms have been shown to be involved in the sepsis-induced prothrombotic state, but clinical scenarios may differ. In this review, we have summarized the role that bacterial products such as porins and toxins can have in the induction of the prothrombotic state during sepsis and the interaction that they can have with each other. Furthermore, the above-mentioned mechanisms might be involved in the pattern of the clinical presentation of thrombotic events during bacterial sepsis, which would secondarily explain the association between sepsis and venous thromboembolism, the association between sepsis and disseminated intravascular coagulation, and the association between sepsis and microangiopathic venous thromboembolism. Full article
(This article belongs to the Topic Bacterial Porins and Their Implication in Pathophysiology of Septic Complications In Vitro and In Vivo)
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<p>Bacterial infection and hypercoagulable state.</p> Full article ">
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