Search Results (11,789)

To effectively and objectively evaluate the spatial efficiency of rail transit station areas, seventeen typical rail station areas in Xi’an were selected as the research object. An evaluation system for spatial efficiency was constructed based on data from field research, satellite images, Baidu heat maps, and station passenger flow statistics. Key factors such as land use, transportation systems, social aspects, and spatial efficiency are considered in the framework. A data envelopment analysis (DEA) method was used to evaluate the spatial efficiency of these sample station areas. The results are as follows. ① An incomplete symmetric relationship exists between the Constant Returns to Scale Technical Efficiency (Crste) and the Variable Returns to Scale Technical Efficiency (Vrste) of station area spatial efficiency. The keys to improving station area spatial efficiency include reducing redundant resource investments and establishing a rational resource allocation structure. ② For high-efficiency station areas, the Crste and Vrste are relatively high, with an overall increasing return to scale efficiency (Scale). In medium-efficiency station areas, the Crste is relatively high, but either Vrste or Scale is low. In low-efficiency station areas, the Crste is moderate, and both Vrste and Scale are low. The findings provide a reference for the intensive use of land around Xi’an rail stations, as well as support for the sustainable operation of rail transit. Full article

Human milk contains a variety of biologically active molecules that are essential for infant growth and development, as well as indicators of maternal health. However, understanding the full potential of these molecules is challenging due to variations in their concentrations among mothers, potential degradation during sample handling and storage, and the limited accessibility of specific human milk analyses. This study aimed to evaluate the effectiveness of a freeze-dried preservative cocktail in maintaining the stability of key milk molecules during collection, transport, and storage. GenV participants (n = 96) were given a sample collection kit and followed the instructions to collect approximately 5 mL of breast milk, which was placed in a collection tube containing the preservative. The samples were mailed at ambient temperature to the GenV laboratory (Murdoch Children’s Research Institute, Melbourne, Victoria, Australia), where they were aliquoted into 1 mL tubes using a liquid handling system (Janus) and stored at −80 °C. These samples were randomly selected and sent to The University of Western Australia (Perth, Western Australia, Australia) on dry ice for biochemical analysis. The average collection day postpartum was 16 ± 14 (range 1–91 days), while the average postal receipt time was 5 ± 3 days (range 1–16 days), and samples were processed within 6 days of receipt (average 3 ± 2 days). The mean concentrations of key molecules—fat (48.6 ± 17.1 g/L), protein (15.5 ± 4.3 g/L), lactose (78.9 ± 13.9 g/L), glucose (0.17 ± 0.17 g/L), lysozyme (0.16 ± 0.16 g/L), and insulin (6.1 ± 4.9 μIU/mL)—were consistent with reported literature values. There were no statistically significant differences in molecular concentrations based on postal transit time, receipt, or processing delays (p > 0.05). These results demonstrate that the preservative cocktail effectively preserved the integrity of key molecules in human milk during handling, postal transport, and storage at ambient temperature. The findings support its use as a valuable tool for human milk research, enabling more flexible sample collection and handling without compromising the quality of the milk or the biochemical analysis. Future research should explore its application in broader contexts to further enhance the accuracy and reliability of milk composition studies across diverse research settings. Full article

The implications of various pH solutions in the gastrointestinal fluid system as solvent-mediated phase transitions on concurrent polymorphism transformation, notably metastable polymorphic forms of Efavirenz (EFV), has never been investigated. The impact will be shifting in the solubility and crystallinity of EFV polymorphisms, particularly metastable Forms II and III. EFV’s metastable form is generated by recrystallization with n-hexane and methanol, which were all immersed in artificial digestion buffer solutions for 10 and 100 h, respectively. Form II showed a 9–13.2% increase in solubility, whereas Form III increased by 2–7.3% over Form I. Interestingly, Form II revealed decreased crystallinity, but Form III tended to retain or slightly increase. In acidic solutions, all metastable polymorphs had the highest solubility and crystallinity. Form III appears to have a lower impact on phase transitions owing to pH variations than Form II. These findings indicate that variability in the pH of digestive secretions are essential steps in developing successful pharmaceutical formulations. Finally, our findings provide information on the complex interaction between solvents, pH variations, and EFV polymorphs. The findings identified the importance of these factors in the development of successful pharmaceutical formulations. Full article

Background/Objectives: Agricultural systems face increasing global pressure to address sustainability challenges, particularly regarding land use and environmental protection. In Romania, where traditional diets are heavily dependent on animal-based products, optimizing land use is critical. This study investigates the potential of plant-based diets to reduce agricultural land use, examining scenarios of partial and complete replacement of animal protein with plant protein sources (soy, peas, and potatoes). Methods: The research modeled three dietary transition scenarios—replacing 33%, 50%, and 100% of animal protein with plant-based protein—using data from the Romanian National Institute of Statistics, the FAO, and international sources. Land use was calculated for each scenario using formulas that take into account protein content and land use intensity for animal and plant protein sources. The simulations quantify the reduction in agricultural land use at the per capita and national levels. Results: The study reveals significant land-saving potential across all scenarios. At the national level, land use reductions ranged from 84,020 hectares (33% replacement) to 1,067,443 hectares (100% replacement). High-impact products such as beef and dairy continue to dominate land use, even in partial replacement scenarios. Conversely, replacing pork and chicken proteins shows substantial savings. The findings highlight the inefficiency of animal-based protein production and the ecological benefits of transitioning to plant-based diets. Conclusions: A dietary shift towards plant-based protein in Romania could achieve significant reductions in agricultural land use, contributing to the Sustainable Development Goals. This transition not only supports environmental conservation and resource optimization, but also provides public health benefits by reducing consumption of red and processed meat. These results provide a basis for policies to promote sustainable and nutritionally balanced food systems Full article

DC micro-grids are emerging as a promising solution for efficiently integrating renewable energy into power systems. These systems offer increased flexibility and enhanced energy management, making them ideal for applications such as heat pump (HP) systems. However, the integration of intermittent renewable energy sources with optimal energy management in these micro-grids poses significant challenges. This paper proposes a novel control strategy designed specifically to improve the performance of DC micro-grids. The strategy enhances energy management by leveraging an environmental mission profile that includes real-time measurements for energy generation and heat pump performance evaluation. This micro-grid application for heat pumps integrates photovoltaic (PV) systems, wind generators (WGs), DC-DC converters, and battery energy storage (BS) systems. The proposed control strategy employs an intelligent maximum power point tracking (MPPT) approach that uses optimization algorithms to finely adjust interactions among the subsystems, including renewable energy sources, storage batteries, and the load (heat pump). The main objective of this strategy is to maximize energy production, improve system stability, and reduce operating costs. To achieve this, it considers factors such as heating and cooling demand, power fluctuations from renewable sources, and the MPPT requirements of the PV system. Simulations over one year, based on real meteorological data (average irradiance of 500 W/m², average annual wind speed of 5 m/s, temperatures between 2 and 27 °C), and carried out with Matlab/Simulink R2022a, have shown that the proposed model predictive control (MPC) strategy significantly improves the performance of DC micro-grids, particularly for heat pump applications. This strategy ensures a stable DC bus voltage (±1% around 500 V) and maintains the state of charge (SoC) of batteries between 40% and 78%, extending their service life by 20%. Compared with conventional methods, it improves energy efficiency by 15%, reduces operating costs by 30%, and cuts CO₂; emissions by 25%. By incorporating this control strategy, DC micro-grids offer a sustainable and reliable solution for heat pump applications, contributing to the transition towards a cleaner and more resilient energy system. This approach also opens new possibilities for renewable energy integration into power grids, providing intelligent and efficient energy management at the local level. Full article

The ability to treat the surface of an object with coatings that counteract the change in radiance resulting from the object’s blackbody emission can be very useful for applications requiring temperature-independent radiance behavior. Such a response is difficult to achieve with most materials except when using phase-change materials, which can undergo a drastic change in their optical response, nullifying the changes in blackbody radiation across a narrow range of temperatures. We report on the theoretical design, giving the possibility of extending the temperature range for temperature-independent radiance coatings by utilizing multiple layers, each comprising a different phase-change material. These designed multilayer coatings are based on thin films of samarium nickelate, vanadium dioxide, and doped vanadium oxide and cover temperatures ranging from room temperature to up to 140 °C. The coatings are numerically engineered in terms of layer thickness and doping, with each successive layer comprising a phase-change material with progressively higher transition temperatures than those below. Our calculations demonstrate that the optimized thin film multilayers exhibit a negligible change in the apparent temperature of the engineered surface. These engineered multilayer films can be used to mask an object’s thermal radiation emission against thermal imaging systems. Full article

Background: Wear particle reaction is present in every arthroplasty. Sometimes, this reaction may lead to formation of large pseudotumors. As illustrated in this case, the volume of the reaction may be out of proportion to the volume of the wear scar. This case also is the first description of elimination kinetics of systemic titanium exposure caused by wear of a hip arthroplasty. Methods: Case report. Results: A 85-year-old male required revision after total hip arthroplasty due to aseptic loosening of the cup. A massive local adverse reaction to metal and polyethylene debris developed before revision, much larger than the implant damage would intuitively suggest. In this case, in vivo transition in wear mode from edge loading to impingement wear resulted in excessive titanium and polyethylene wear and subsequently a voluminous macrophage reaction and an excessive systemic titanium exposure, with blood concentrations showing a very long elimination half-life of more than two years. Conclusions: The volume of the wear particle reaction is dictated by the volume of the inflammatory cells, not of the wear particles. To the best of our knowledge, this is the first description of elimination kinetics in case of systemic titanium exposure. While the tissue response is caused by a sudden increase of titanium and polyethylene debris, titanium is detectable through whole blood, not serum, analysis and thus be an indicator for risk of failure due to abnormal articulation of the joint replacement. Such measurement may be useful if changes in implant position are detected radiographically. Major elevations of titanium concentrations may require revision, as for any other metal ions. Full article

Zwitterionic polymers have garnered significant attention for their distinctive properties, such as biocompatibility, antifouling capabilities, and resistance to protein adsorption, making them promising candidates for a wide range of applications, including drug delivery, oil production inhibitors, and water purification membranes. This study reports the synthesis and characterization of zwitterionic monomers and polymers through the modification of linear, vinyl, and aromatic heterocyclic functional groups via reaction with 1,3-propanesultone. Four zwitterionic polymers with varying molecular structures—ranging from linear to five and six membered ring systems—were synthesized: poly(sulfobetaine methacrylamide) (pSBMAm), poly(sulfobetaine-1-vinylimidazole) (pSB1VI), poly(sulfobetaine-2-vinylpyridine) (pSB2VP), and poly(sulfobetaine-4-vinylpyridine) (pSB4VP). Their molecular weights, thermal behavior, and self-assembly properties were analyzed using gel permeation chromatography (GPC), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), transmission electron microscopy (TEM), and zeta potential measurements. The glass transition temperatures (Tg) ranged from 276.52 °C for pSBMAm to 313.69 °C for pSB4VP, while decomposition temperatures exhibited a similar trend, with pSBMAm degrading at 301.03 °C and pSB4VP at 387.14 °C. The polymers’ self-assembly behavior was strongly dependent on pH and their surface charge, particularly under varying pH conditions: spherical micelles were observed at neutral pH, while fractal aggregates formed at basic pH. These results demonstrate that precise modifications of the chemical structure, specifically in the linear, imidazole, and pyridine moieties, enable fine control over the thermal properties and self-assembly behavior of polyzwitterions. Such insights are essential for tailoring polymer properties for targeted applications in filtration membranes, drug delivery systems, and solid polymer electrolytes, where thermal stability and self-assembly play crucial roles. Full article

Urbanized riverine cities in southern Asian developing countries face significant challenges in understanding the spatiotemporal thermal impacts of land use/land cover (LULC) changes driven by rapid urbanization and climatic variability. While previous studies have investigated factors influencing land surface temperature (LST) variations, gaps persist in integrating Landsat imagery (7 and 8), meteorological data, and Geographic Information System (GIS) tools to evaluate the thermal effects of specific LULC types, including cooling and warming transitions, and their influence on air temperature under variable precipitation patterns. This study investigates LST variations in Islamabad, Pakistan, from 2000 to 2020 using quantile classification at three intervals (2000, 2010, 2020). The thermal contributions of each LULC type across the LST-based temperature classes were analyzed using the Land Contribution Index (LCI). Finally, Warming and Cooling Transition (WCT) maps were generated by intersecting LST classes with 2000 as the baseline. Results indicated a rise in LST from 32.39 °C in 2000 to 45.63 °C in 2020. The negative LCI values revealed that vegetation and water bodies in lower temperature zones (Ltc_1 to Ltc_3) contributed to cooling effects, while positive LCI values in built-up and bare land areas in higher temperature zones (Ltc_5–Ltc_7) exhibited warming effects. The WCT map showed a general warming trend (cold-to-hot type) from 2000 to 2020, particularly in newly urbanized areas due to a 49.63% population increase, while cooling effects (hot-to-cold type) emerged in the newly developed agricultural lands with a 46.46% rise in vegetation. The mean annual air temperature gap with LST narrowed from 11.55 °C in 2000 to 2.28 °C in 2020, reflecting increased precipitation due to increasing yearly rainfall from 982.88 mm in 2000 to 1365.47 mm in 2020. This change also coincided with an expansion of water bodies from 2.82 km² in 2000 to 6.35 km² in 2020, impacting the local climate and hydrology. These findings highlight the importance of green spaces and water management to mitigate urban heat and improve ecological health. Full article

Mammalian blood cells originate from specialized ‘hemogenic’ endothelial (HE) cells in major arteries. During the endothelial-to-hematopoietic transition (EHT), nascent hematopoietic stem cells (HSCs) bud from the arterial endothelial wall and enter circulation, destined to colonize the fetal liver before ultimately migrating to the bone marrow. Mechanisms and processes that facilitate EHT and the release of nascent HSCs are incompletely understood, but may involve signaling from neighboring vascular endothelial cells, stromal support cells, circulating pre-formed hematopoietic cells, and/or systemic factors secreted by distal organs. We used single cell RNA sequencing analysis from human embryonic cells to identify relevant signaling pathways that support nascent HSC release. In addition to intercellular and secreted signaling modalities that have been previously functionally validated to support EHT and/or developmental hematopoiesis in model systems, we identify several novel modalities with plausible mechanisms to support EHT and HSC release. Our findings paint a portrait of the complex inter-regulated signals from the local niche, circulating hematopoietic/inflammatory cells, and distal fetal liver that support hematopoiesis. Full article

Cleavable bio-based epoxy resin systems are emerging, eco-friendly, and promising alternatives to the common thermoset ones, providing quite comparable thermo-mechanical properties while enabling a circular and green end-of-life scenario of the composite materials. In addition to being designed to incorporate a bio-based resin greener than the conventional fully fossil-based epoxies, these formulations involve cleaving hardeners that enable, under mild thermo-chemical conditions, the total recycling of the composite material through the recovery of the fiber and matrix as a thermoplastic. This research addressed the characterization, processability, and recyclability of a new commercial cleavable bio-resin formulation (designed by the R-Concept company) that can be used in the fabrication of fully recyclable polymer composites. The resin was first studied to investigate the influence of the different post-curing regimes (room temperature, 100 °C, and 140 °C) on its thermal stability and glass transition temperature. According to the results obtained, the non-post-cured resin displayed the highest T_g (i.e., 76.6 °C). The same post-curing treatments were also probed on the composite laminates (glass and carbon) produced via a lab-scale vacuum-assisted resin transfer molding system, evaluating flexural behavior, microstructure, and dynamic-mechanical characteristics. The post-curing at 100 °C would enhance the crosslinking of polymer chains, improving the mechanical strength of composites. With respect to the non-post-cured laminates, the flexural strength improved by 3% and 12% in carbon and glass-based composites, respectively. The post-curing at 140 °C was instead detrimental to the mechanical performance. Finally, on the laminates produced, a chemical recycling procedure was implemented, demonstrating the feasibility of recovering both thermoplastic-based resin and fibers. Full article

So far, most of the about 5700 exoplanets have been discovered mainly with radial velocity and transit methods. These techniques are sensitive to planets in close orbits, not being able to probearge star–planet separations. μ-lensing is the indirect method that allows us to probe the planetary systems at the snow-line and beyond, but it is not a repeatable observation. On the contrary, direct imaging (DI) allows for the detection and characterization ofow mass companions at wide separation (≤5–6 au). The main challenge of DI is that a typical planet–star contrast ranges from 10⁻⁶, for a young Jupiter in emittedight, to 10⁻⁹ for Earth in reflectedight. In theast two decades, aot of efforts have been dedicated to combiningarge (D ≥ 5 m) telescopes (to reduce the impact of diffraction) with coronagraphs and high-order adaptive optics (to correct phase errors induced by atmospheric turbulence), with sophisticated image post-processing, to reach such a contrast between the star and the planet in order to detect and characterize cooler and closer companions to nearby stars. Building on the first pioneering instrumentation, the second generation of high-contrast imagers, SPHERE, GPI, and SCExAO, allowed us to probe hundreds of stars (e.g., 500–600 stars using SHINE and GPIES), contributing to a better understanding of the demography and the occurrence of planetary systems. The DI offers a possible clear vision for studying the formation and physical properties of gas giant planets and brown dwarfs, and the future DI (space and ground-based) instruments with deeper detectionimits will enhance this vision. In this paper, we briefly review the methods, the instruments, the main sample of targeted stars, the remarkable results, and the perspective of this rising technique. Full article

The most effective way to solve urban traffic congestion in mega cities is to develop rail transit, which is also an important strategy for sustainable urban development. Improving the service performance of rail transit equipment is the key to ensuring the sustainable operation of urban rail transit. Automatic fare collection (AFC) is an indispensable system in urban rail transit. AFC directly serves passengers, and its condition directly affects the sustainability and safety of urban rail transit. This study proposes remaining useful life (RUL) prediction framework for AFC systems. Firstly, it proposes the quantification of AFC health state based on health degree, and proposes a health state assessment method based on digital analog fusion, which compensates for the shortcomings of single data-driven or model driven health methods. Secondly, it constructs a multi feature extraction method based on multi-layer LSTM, which can capture long-term temporal dependencies and multi-dimensional feature, overcoming the limitation of low model accuracy because of the weak data features. Then, the SSA-XGBoost model for AFC RUL prediction is proposed, which effectively performs global and local searches, reduces the possibility of overfitting, and improves the accuracy of the prediction model. Finally, we put it into practice of the AFC system of Shanghai Metro Line 10. The experiment shows that the proposed model has an MSE of 0.00111 and MAE of 0.02869 on the test set, while on the validation set, MSE is 0.00004 and MAE is 0.00659. These indicators are significantly better than other comparative models such as XGBoost, random forest regression, and linear regression. In addition, the SSA-XGBoost model also performs well on R-squared, further verifying its effectiveness in prediction accuracy and model fitting. Full article

Considering the ambitious climate goals defined by the European Union, the significant share of energy demand represented by buildings, the slow process of their renovation due to challenges such as a need for majority consent from residents and limited available space in dense urban areas, this study aims to foster retrofitting of energy supply systems of multi-storey apartment buildings, improving their sustainability. This entails making the transition to sustainable energy systems more socially acceptable and practical in urban contexts by proposition and demonstration of the potential of a power and heat supply system retrofit that minimises disruptions felt by residents. It integrates rooftop renewable power sources, heat storage with an electric heater, heat pumps, and existing connections to public utility networks. Furthermore, simulation results of both single- and multi-objective optimisation (performed by the genetic algorithm) for equipment selection, as well as conventional and smart control (implemented as a gradient-based optimisation) for daily scheduling, are compared, defining the main scientific contribution of the study. It is found possible to achieve a net present value of up to almost twice the annual energy expenses of the unrenovated building or self-sufficiency rate of up to 41.6% while using conventional control. These benefits can reach 2.6 times or 49.8% if the smart control is applied, demonstrating both the profitability and improved self-sufficiency achievable with the proposed approach in Latvian conditions. Full article

This study introduces a novel single-degree-of-freedom polycentric knee mechanism specifically designed for transfemoral prostheses to address dual challenges of stability during the stance phase and biomimetic motion during the swing phase. Leveraging analytical kinematic synthesis, the proposed mechanism integrates separate kinematic designs for each of the gait phases into a combined structure that prevents singularity issues during full knee flexion, which is a significant limitation in conventional active designs. The stance phase mechanism emphasizes stability through precise control of the instantaneous center of rotation (ICR) and weight-bearing support, while the swing phase mechanism adopts a biomimetic motion trajectory. In order to validate the proposed methodology, kinematic synthesis, numerical simulations, and visual analyses were conducted. Incorporating insights from polycentric prostheses and orthotic applications, the proposed mechanism achieves a seamless transition between two different configurations by keeping its overall mobility. Additionally, its possible compatibility with motorized actuation offers a foundation for active prosthesis systems, paving the way for adapting the advantages of polycentric prosthesis to active devices. This innovative approach offers a scientifically grounded pathway for improving transfemoral prosthetic systems, advancing both their biomechanical utility and user comfort. Full article