Search Results (1,045)

Background and Objectives: Given that COVID-19 vaccination is a relatively recent development, particularly when compared to immunisation against other diseases, it is crucial to assess its efficacy in vaccinated populations. This literature review analysed studies that monitored antibody titres against SARS-CoV-2 in healthcare workers who received COVID-19 vaccines. Methods: Using the PICO (Population, Intervention, Comparators, Outcomes) model recommended in the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines we included 43 publications which analyse antibody dynamics following primary vaccination, the effects of booster doses, and the influence of factors such as COVID-19C infection, age, and sex on antibody kinetics. Results: All the studies demonstrated a strong immunogenic response to the vaccines. Re-gardless of the vaccine used, over 95% of the pre-vaccination seronegative population be-came seropositive in all studies. Depending on the sampling intervals provided by the re-searchers, antibody levels were quantitatively highest during the first three months after vaccination, but levels inevitably declined over time. The monthly decline in antibodies observed in all these studies highlighted the necessity for booster doses. Studies analysing the impact of revaccination on antibody dynamics have confirmed that revaccination is an effective tool to boost humoral immunity against SARS-CoV-2. An-tibodies appear to persist for a longer period of time after revaccination, although they are subject to similar factors influencing antibody dynamics, such as age, comorbidities, and exposure to COVID-19. In addition, heterogeneous revaccination strategies have been shown to be more effective than homogeneous revaccination. Conclusions: Our review demonstrated that antibody levels against SARS-CoV-2 inevitably decline after vaccination, leaving the question of ongoing booster strategies open. The studies reviewed provided evidence of the effectiveness of booster vaccination, despite differences in age, sex, and prior COVID-19 infection. This suggests that repeated vaccination remains a highly effective method for mitigating the continued threat posed by COVID-19. Full article

The objective of cross-city recommendation is to suggest points-of-interest (POI) in the target city that may be of interest to users, based on their check-in records from their source city. Although significant progress has been made in studying user preference transfers, there is a lack of research focusing on personalized user preference transfers. Furthermore, the mining of user preferences from the source city is impacted by errors and missing information. To address these challenges, this paper proposes a Check-In Heterogeneous Hypergraph and Personalized Preference Transfers for Cross-City POI Recommendation Method (CHHPPT). Firstly, a check-in heterogeneous hypergraph network is introduced in the user source city preference-mining module. This network, through Heterogeneous Hypergraph Embeddings (HHE), captures user preferences in the source city, thereby mitigating the impact of errors and missing information on user preference. Subsequently, in the user-personalized preference transfer module, a user’s transferable features are obtained through a POI aggregation network. These features are then combined with a meta-network and transfer networks to achieve user-personalized preference transfer. Finally, in the target city point-of-interest recommendation module, a POI-geographical graph is constructed using the geographical information of POI. This graph, in conjunction with category information, yields a joint embedding representation. The final recommendation is achieved by integrating the user-personalized preference transfer embeddings with the target city’s POI embeddings. Extensive experiments conducted on two real-world datasets demonstrate the effectiveness of CHHPPT in cross-city recommendation tasks. Full article

Background: Autism spectrum disorder is a multifactorial phenomenon whose genetic, biological, environmental, and nutritional factors outline the heterogeneous phenotype of the disease. A limitation in social connections with others, stereotyped reactions, and specific interests and preferences characterize the behavioral manifestations of a person with autism. Also, weaknesses are found in emotional, cognitive, and metacognitive development, significantly burdening the individual’s quality of life. Lately, it has gained widespread acceptance that the gut microbiome and neurotransmission constitute two decisive etiological factors of autism both in the prenatal period and postnatally. This study aims to investigate data on the interaction between the quantitative and qualitative composition of the gut flora and neurotransmission in humans, as well as their influences on the appearance and progression of the symptoms of autism spectrum disorder. At the same time, it captures the role of digital technology in diagnosing and intervening in autism, which is mainly related to the individual subjects under study. Methods: The current research employs an exploratory review to provide a concise overview of the complex neuronal functions associated with neurotransmitter action and the homeostasis mechanisms that allow the brain and the human body to survive and perform optimally. Results: A review of 111 sources highlighted the connection of dietary habits with synthesizing and releasing neurotransmitters and their influence on the emergence of autism-related behaviors. Conclusions: The literature review’s findings revealed the importance and influence of nutritional factors on neurotransmission performance and behavioral, social, and cognitive development among individuals with autism. Moreover, it is noteworthy that combining a healthy lifestyle and the targeted use of digital tools can improve the intensity of autism symptoms. Full article

Background: Oestradiol has been implicated as a factor in substrate utilisation in male and mouse studies but the effect of acute changes during the menstrual cycle is yet to be fully understood. Objective: To determine the role of oestradiol in respiratory exchange ratio (RER) during exercise at various intensities. Methods: This systematic review was conducted and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. From inception to November 2023, four online databases (Cochrane, SPORTDiscus, MEDline and Web of Science) were searched for relevant articles. Studies that reported a resting oestradiol measurement in naturally menstruating women with exercise at a percentage of maximal aerobic capacity (%V˙O_2max) were included. Mean and standard deviation for oestradiol, RER and exercise intensity were extracted and study quality assessed using a modified Downs and Black checklist. Risk of bias was assessed using I₂ measure of heterogeneity and Egger’s regression test, assessment of bias from methodological quality was identified by sensitivity analysis. Eligible datasets were extracted for pairwise comparisons within a meta-analysis and correlation between change in oestradiol and change in RER. Data were also pooled to produce a mean and standard deviation for RER for menstrual stage and for low and high oestradiol groups. Results: Twenty-four articles were identified, over 50% were identified as high quality. Sixteen articles included datasets eligible for meta-analysis. Eleven articles utilised a submaximal constant-load exercise intensity, finding a standardised mean difference of − 0.09 ([CI: −0.35–0.17], p = 0.5) suggesting no effect of menstrual phase on constant-load exercise RER. In six articles using incremental exercise tests to exhaustion, a standardised mean difference of 0.60 ([CI 0.00–1.19], p = 0.05) was identified towards a higher maximal RER attained in follicular compared to luteal phase. There was no correlation (R = −0.26, p = 0.2) between change in oestradiol and change in RER between phases. All 24 articles, totalling 650 participants, were included in pooled analysis. When grouped by menstrual cycle phase or when grouped by oestradiol levels, RER was higher in the follicular phase than the luteal phase at low and high constant load exercise intensities. Discussion: Findings from the pooled-analysis and meta-analysis suggest that there may be menstrual cycle phase differences in RER that are intensity dependent. These differences may be related to sex hormone levels, but this was not supported by evidence of correlation between differences in RER and differences in oestradiol. At present, it remains best practice to assess performance in the same menstrual cycle phase if seeking to assess change from baseline. Full article

Household food waste contributes to 60% of the total global food waste. Based on an online questionnaire survey on household food waste in China, this paper explores the association between food safety preference and household food waste. This demonstrates that (1) the excessive concern about food safety significantly increased the proportion of household food waste, the weight of food wasted, and the food waste ratio. The robustness tests supported this finding. (2) heterogeneity analysis showed that the impact of the safety preference on the likelihood of household food waste varied by the gender of respondents, household size, and urban–rural type. The effect of safety preference on the weight of food wasted in the household varied by the gender and education level, household size, income level, urban–rural type, and located region. Thus, the study provides evidence for reducing household food waste in Chinese households through the popularization of food safety knowledge, which has certain implications for reducing food waste and achieving sustainable food consumption in other developing countries. Full article

Background and Objectives: Despite frequent references to the high prevalence of vitamin D deficiency in Kazakhstan, a comprehensive synthesis of existing research on this issue among adults is lacking. This systematic review and meta-analysis aim to address this gap by determining the mean prevalence of vitamin D deficiency among adults in Kazakhstan. A secondary objective is to evaluate whether the prevalence differs between healthy adults and those with chronic conditions. Materials and Methods: A systematic search was conducted in PubMed, Scopus, ScienceDirect, Web of Science, and Google Scholar by two independent researchers using the keywords: “vitamin D” AND “Kazakhstan”, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies were included if they reported the prevalence of vitamin D in adults in Kazakhstan, defined as a blood level of 25-hydroxyvitamin D 25(OH)D below 20 ng/mL. Results: Seven studies were included in this review, encompassing 3616 individuals, of whom 2239 had vitamin D deficiency. Using a random-effects model, the pooled mean prevalence of vitamin D deficiency among adults with chronic conditions was 60% (95% CI, 38–79%), with high heterogeneity. Similarly, the analysis of five studies involving healthy adults revealed a pooled mean prevalence of 55% (95% CI, 38–70%), also with high heterogeneity. Overall, the pooled mean prevalence of vitamin D deficiency in the adult population was 57% (95% CI, 45–69%). Conclusions: This analysis indicates a high prevalence of vitamin D deficiency among adults in Kazakhstan, with 57% of the population affected. Addressing this issue requires a multifaceted approach, including policy reforms that consider the impact of time zone changes on sunlight exposure and the active involvement of nurse practitioners in preventive strategies. Full article

Non-satisfactory bread-making quality in wheat, a Tajik staple, hampers food security in Tajikistan and calls for plant breeding efforts. Here, methods were searched for to study grain protein composition, which is of use for Tajik plant breeding to improve bread-making quality. Size-exclusion high-performance liquid chromatography (SE-HPLC) was used to determine protein composition in 22 wheat varieties and breeding lines grown in two locations, which were then compared with the specific protein composition evaluated using electrophoresis and previous results from Tajik breeding and farmer-grown wheat. As Tajik wheat generally showed a large variation in high-molecular-weight glutenin subunit (HMW-GS) composition, with several allelic variants in the same line, single-seed selection was required when using this methodology in breeding for improved bread-making quality, and such an evaluation willalso result in more homogenous lines for protein composition. SE-HPLC was found to be a suitable tool to evaluate protein composition in the current Tajik wheat material with a heterogeneous protein composition, which might be advantageous for adaptation to the local and future climate. However, more easy-to-handle and high-throughput methods, e.g., marker-assisted selection, could be preferable alternatives for studying protein composition in wheat and for use in breeding for increased bread-making quality to increase food security in Tajikistan. Full article

This paper addresses the critical challenges of renewable energy integration and regional power balance in smart grids, which have become increasingly complex with the rapid growth of distributed energy resources. It proposes a novel three-layer scheduling framework with a dynamic peer-to-peer (P2P) trading mechanism to address these challenges. The framework incorporates a preliminary local supply–demand balance considering renewable energy, followed by an inter-regional P2P trading layer and, ultimately, flexible resource deployment for final balance adjustment. The proposed dynamic continuous P2P trading mechanism enables regions to autonomously switch roles between buyer and seller based on their internal energy status and preferences, facilitating efficient trading while protecting regional privacy. The model features an innovative price update mechanism that initially leverages historical trading data and dynamically adjusts prices to maximize trading success rates. To address the heterogeneity of regional resources and varying energy demands, the framework implements a flexible trading strategy that allows for differentiated transaction volumes and prices. The effectiveness of the proposed framework is validated through simulation experiments using k-means clustered typical daily data from four regions in Northeast China. The results demonstrate that the proposed approach successfully promotes renewable energy utilization, reduces the operational costs of flexible resources, and achieves an efficient inter-regional energy balance while maintaining regional autonomy and information privacy. Full article

This study investigated vegetable farmers’ willingness-to-pay (WTP) for private agricultural advisory services in northwestern Ethiopia. Understanding farmers’ preferences is a crucial step for modernizing agricultural advisory services and transforming smallholder agri-food systems into a sustainable path. Discrete choice experiment data from 393 farm households were analyzed using a random parameter logit model (RPL). The results revealed that vegetable farmers are willing to pay for practice-oriented private advisory services. The result also showed the existence of heterogeneity in farmers’ preference for features of vegetable advisory services. Household heads’ educational status and age influenced preferences for advisory service features. The result is substantiated by the fact that merely 25.5% of the sample households acquired formal education. Farmers in general preferred extension services with frequent expert visits and practical engagement on-farm as opposed to digitized options that rely on short message service (SMS) and voice-based guidance. Additionally, farmers are willing to pay an ETB 120.89 and ETB 203.94 monthly fee for an extension service that emphasizes fruity and root and tuber vegetables, respectively, as opposed to leafy vegetables. The findings imply initiatives that push for commercializing agricultural advisory services should strive to achieve a balance between the practical application and digitization of extension services accounting for the heterogeneous preferences of smallholder farmers. Full article

Objective: This study aimed to perform an umbrella review of existing systematic reviews on the effects of saddle position on cycling. Material and methods: We conducted a systematic search across the electronic databases EBSCO, PubMed, Scopus, Web of Science, and B-On for systematic reviews investigating the effects of saddle position on cycling, following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. To prevent the risk of bias, two researchers independently performed the search. To evaluate the methodological quality of the included reviews, the Assessing the Methodological Quality of Systematic Reviews 2 (AMSTAR 2) checklist was used. Results: A total of seven systematic reviews that met the eligible criteria were included. The systematic reviews showed high heterogeneity among themselves (e.g., type of included studies, participants’ characteristics, or evaluated outcomes) and low to critically low methodological quality. Relationships have been found between the rider’s saddle position and health issues (such as low back pain (four studies), knee injury or pain (three studies), lumbar kyphosis (one study), and impact on perineum (two studies)), and on performance alterations (such as, muscle activation, oxygen uptake, load and intensity, efficiency (one study), and comfort (one study)). The results showed that some research provided conflicting evidence in regard to the studied relations (e.g., knee injury or pain, impact on perineum, and efficiency). Conclusions: Cyclists’ saddle position impacts various issues related to health and performance. More research is needed, and future studies should focus on the clarification of the conflicting evidence observed in this review. Full article

The occurrence of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae in vegetables is an escalating global problem. This study aimed to document the global prevalence of ESBL-producing Enterobacteriaceae in vegetables using a comprehensive meta-analysis. A web-based search of electronic databases such as ScienceDirect, Google Scholar, and PubMed was conducted using studies published between 2014 and 2024. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines were followed for the systematic review and meta-analysis. The Comprehensive Meta-Analysis (CMA) Ver 4.0 software was used to analyse the data. The pooled prevalence estimate (PPE) with a 95% confidence interval (CI) was calculated using the random effects model. After reviewing 1802 articles, 63 studies were carefully analyzed and were part of the comprehensive meta-analysis. The overall PPE of ESBL-producing Enterobacteriaceae (ESBL-E) was 11.9% (95% CI: 0.091–0.155), with high heterogeneity (I² = 96.8%, p < 0.001) from 2762 isolates. The bla_SHV ESBL-encoding gene was the most prevalent, showing a PPE of 42.8% (95% CI: 0.269–0.603), while the PPE of bla_ampC-beta-lactamase-producing Enterobacteriaceae was 4.3% (95% CI: 0.025–0.71). Spain had a high ESBL-E PPE of 28.4% (0.284; 95% CI: 0.057–0.723, I² = 98.2%), while China had the lowest PPE at 6.4% (0.064; 95% CI: 0.013–0.259, I² = 95.6%). Continentally, the PPE of ESBL-E was significantly higher in reports from South America at 19.4% (95% CI: 0.043–0.560). This meta-analysis showed that ESBL-E in vegetables increased by 9.0%, 9.8%, and 15.9% in 2018–2019, 2020–2021, and 2022–2024, respectively. The findings emphasize the potential risks of consuming raw or inadequately cleaned produce and the importance of vegetables as ESBL-E reservoirs. Our work calls for immediate attention to food safety procedures and more thorough surveillance as antibiotic resistance rises to reduce antimicrobial resistance risks in food systems. Full article

Background: In the world, approximately 1% of the population suffers from chronic spontaneous urticaria (CSU), burdening patients’ quality of life and challenging clinicians in terms of treatment. Recent scientific evidence has unveiled the potential role of a family of molecules known as “alarmins” in the pathogenesis of CSU. Methods: Papers focusing on the potential pathogenetic role of alarmins in CSU with diagnostic (as biomarkers) and therapeutic implications, in English and published in PubMed, Scopus, Web of Science, as well as clinical studies registered in ClinicalTrials.gov and the EudraCT Public website, were reviewed. Results: The epithelial-derived alarmins thymic stromal lymphopoietin and IL-33 could be suitable diagnostic and prognostic biomarkers and possible therapeutic targets in CSU. The evidence on the role of non-epithelial-derived alarmins (heat shock proteins, S-100 proteins, eosinophil-derived neurotoxin, β-defensins, and acid uric to high-density lipoproteins ratio) is more heterogeneous and complex. Conclusions: More homogeneous studies on large cohorts, preferably supported by data from international registries, will be able to elucidate the intriguing and complex pathogenetic world of CSU. Full article

Background:Running is one of the simplest and most popular forms of exercise. Biomechanical evaluation of running is one of the elements of evaluating running technique and, consequently, improving sports performance. Running uphill and downhill is one of the components of daily running but also an element of training used by recreational runners. The aim of this study is to optimize running training and minimize the risk of injury by identifying changes in the spatiotemporal structure of running at different inclinations. Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. The protocol has been registered on the international platform INPLASY under the number INPLASY202430094U2. The search was conducted up to 30 March 2024 using the Scopus, PubMed, and Web of Science databases. Results: Spatiotemporal parameters were most frequently analyzed at 2.8–3.35 m/s velocities and inclinations in the range of −11% to 11%. Decreases in stride length (SL) and flight time (FT), and increases in step frequency (SF) were the most frequently reported changes from all parameters analyzed as a function of inclination and velocity. Significant increases or decreases in individual parameters were more often observed for positive inclination values than negative ones. Conclusions: The heterogeneous results of the study limit the possibility of determining the changes that occur in the spatiotemporal structure of the run under the impact of different inclinations. The variation in the results for negative inclination values indicates the different characteristics of running uphill and downhill. However, for uphill running, SF, SL, and FT are closely related to the increase in inclination. Full article

Salmonella enterica subsp. enterica serovar Infantis poses a growing threat to public health, due to its increasing prevalence worldwide and its association with high levels of antimicrobial resistance. Among livestock, S. Infantis is especially isolated from broilers. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic review was conducted by searching in three databases (Web of Science, Scopus, and PubMed) for English-language studies (1957–2023) that reported the prevalence of S. Infantis in broiler farms. Eligible studies included epidemiological investigations conducted in broiler chickens by sampling the house environment (flock-level prevalence) or the birds (individual-level prevalence). A random-effect model was applied to calculate S. Infantis pooled prevalence estimates with 95% confidence intervals (CIs). Furthermore, to assess between-study heterogeneity, the inconsistency index statistic (I²) was calculated. Among 537 studies retrieved, a total of 9 studies reporting flock-level prevalence of S. Infantis and 4 reporting individual-level prevalence were retained for analysis. The flock-level pooled prevalence was estimated to be 9% (95% CI: 1–26%) and a high between-study heterogeneity was found (I² = 99%, p < 0.01). Concerning individual-level prevalence, a meta-analysis was not performed due to the scarcity of eligible studies. The data presented underscore the significant occurrence of S. Infantis in broilers at the farm level. By summarizing the existing literature, this work provides useful insights for conducting future surveys of Salmonella spp. in live broiler chickens as a preliminary step for developing more efficient control strategies. Full article

Despite the growing body of evidence addressing the reasons behind vaccine hesitancy, the positive role of media as a key environmental factor influencing vaccination, as well as its function in publicizing and encouraging vaccination, has been less thoroughly explored. This study focuses on the context of the current Monkeypox epidemic, examining the influence of media release channels and message framing on the public’s willingness to receive the Monkeypox vaccine. The findings are empirically validated through a survey experiment conducted in China. The study reveals that both media channels—traditional TV media, official online media, and user-generated media—and media content framings, specifically thematic and episodic, significantly impact the public’s willingness to be vaccinated against Monkeypox. Notably, in the context of this public health event, individuals were more inclined to trust the episodic framing of traditional TV media and the thematic framing of official online media. Compared to thematic framing, episodic framing generally enhances respondents’ willingness to vaccinate. Furthermore, user-generated media exhibited a more negative effect on vaccination intentions during the Monkeypox epidemic, particularly when combined with episodic framing. Heterogeneity analysis indicated a significant difference in the effectiveness of official online media based on audience identity (student vs. non-student), with the student group showing a preference for official online media channels. The findings underscore the importance of public health communication in carefully selecting media release types and message framings. Additionally, it is crucial to consider audience heterogeneity and to employ differentiated communication methods to enhance the effectiveness of vaccine promotion. Full article