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Search Results (383)

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Keywords = soft sensor model

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17 pages, 1911 KiB  
Article
Metrologically Interpretable Soft-Sensing Technique for Non-Invasive Liquid Flow Estimation from Vibration Data
by Gabriel Thaler, João P. Z. Machado, Rodolfo C. C. Flesch and Antonio L. S. Pacheco
Metrology 2025, 5(1), 6; https://doi.org/10.3390/metrology5010006 - 15 Jan 2025
Viewed by 96
Abstract
This paper proposes a metrologically interpretable soft sensing method for estimating the liquid flow rates in hydraulic systems from non-invasive vibration frequency power band data. Despite considerable interest in non-invasive flow estimation, state-of-the-art methods provide little to no metrological capabilities. In this work, [...] Read more.
This paper proposes a metrologically interpretable soft sensing method for estimating the liquid flow rates in hydraulic systems from non-invasive vibration frequency power band data. Despite considerable interest in non-invasive flow estimation, state-of-the-art methods provide little to no metrological capabilities. In this work, a dedicated test rig was developed to automatically acquire vibration and flow rate data from a centrifugal pump, in a flow rate range between 0.05 × 10−5m3/s and 9.11 × 10−5m3/s. The vibration data were processed into power bands, which were subsequently used to optimize and train a multilayer perceptron neural network for flow soft sensing. The trained model was compared with models with different vibration processing methods from literature. The power band processing model resulted in a root mean squared error 75.4% smaller than the second-best model in cross-validation, and 51.5% smaller with test data. The uncertainty of the proposed regression model was estimated using a combination of ensemble learning and Monte Carlo simulations, and combined with the reference flow sensor uncertainty to obtain the total combined uncertainty of the soft sensor, found to be between 3.9 × 10−6m3/s and 6.1 × 10−6m3/s throughout the measured flow range. The reference flow sensor accuracy was found to be the largest individual contribution for the final uncertainty, closely followed by the regression model uncertainty. Full article
(This article belongs to the Collection Measurement Uncertainty)
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<p>A diagram of the proposed method.</p>
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<p>The P&amp;ID of the experimental test rig. The flow transducer (FT) measures the real-time flow rate for further model training, while the vibration transducer (VT) captures pump vibration data to serve as input.</p>
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<p>The average flow for the evaluated experimental conditions.</p>
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<p>Vibration data processing: (<b>a</b>) vibration signal in the time domain; (<b>b</b>) amplitude spectrum of the vibration signal FFT; (<b>c</b>) frequency bands from the FFT, calculated with a width of 100 Hz and a 5% overlap.</p>
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<p>Cross-validation errors for different power-band processing parameters.</p>
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<p>Comparison of vibration processing methods for flow estimation using MLP.</p>
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<p>The uncertainty estimation for the trained model: (<b>a</b>) soft-sensor predictions; (<b>b</b>) the predicted distribution of 10 samples; (<b>c</b>) the individual and combined uncertainties of the proposed soft-sensing method.</p>
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17 pages, 8323 KiB  
Article
A Symmetrical Leech-Inspired Soft Crawling Robot Based on Gesture Control
by Jiabiao Li, Ruiheng Liu, Tianyu Zhang and Jianbin Liu
Biomimetics 2025, 10(1), 35; https://doi.org/10.3390/biomimetics10010035 - 8 Jan 2025
Viewed by 405
Abstract
This paper presents a novel soft crawling robot controlled by gesture recognition, aimed at enhancing the operability and adaptability of soft robots through natural human–computer interactions. The Leap Motion sensor is employed to capture hand gesture data, and Unreal Engine is used for [...] Read more.
This paper presents a novel soft crawling robot controlled by gesture recognition, aimed at enhancing the operability and adaptability of soft robots through natural human–computer interactions. The Leap Motion sensor is employed to capture hand gesture data, and Unreal Engine is used for gesture recognition. Using the UE4Duino, gesture semantics are transmitted to an Arduino control system, enabling direct control over the robot’s movements. For accurate and real-time gesture recognition, we propose a threshold-based method for static gestures and a backpropagation (BP) neural network model for dynamic gestures. In terms of design, the robot utilizes cost-effective thermoplastic polyurethane (TPU) film as the primary pneumatic actuator material. Through a positive and negative pressure switching circuit, the robot’s actuators achieve controllable extension and contraction, allowing for basic movements such as linear motion and directional changes. Experimental results demonstrate that the robot can successfully perform diverse motions under gesture control, highlighting the potential of gesture-based interaction in soft robotics. Full article
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<p>Angle schematic diagram.</p>
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<p>Overall system schematic diagram.</p>
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<p>Dynamic gesture features related to palms.</p>
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<p>BP neural network diagram.</p>
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<p>Dynamic gesture recognition process.</p>
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<p>The change diagram of the cost function.</p>
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<p>Structure diagram of TPU soft crawling robot.</p>
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<p>Schematic diagram of positive and negative voltage switching circuits.</p>
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<p>System control.</p>
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<p>Schematic diagrams of positive and negative voltage switching circuits. (<b>a</b>) The curved actuators in the rear are bent. (<b>b</b>) The inflatable actuators of the left and right expandable actuators are inflated and expanded. (<b>c</b>) The inflatable actuators of the front are inflated and bent. (<b>d</b>) The curved actuators in the rear are deflated. (<b>e</b>) The actuators of the left and right expandable are deflated.</p>
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<p>Model of the soft robot.</p>
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<p>The linear motion of the TPU soft crawling robot (the red dotted line represents the initial position). (<b>a</b>) The curved actuators in the rear are bent. (<b>b</b>) The inflatable actuators of the left and right expandable actuators are inflated and expanded. (<b>c</b>) The inflatable actuators of the front are inflated and bent. (<b>d</b>) The curved actuators in the rear are detached from the ground. (<b>e</b>) The actuators of the left and right expandable are deflated under negative pressure. (<b>f</b>) The curved actuators of the front are detached from the ground.</p>
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<p>The TPU soft crawling robot changes direction during movement (the red dotted line represents the state of the two plates during the robot’s movement). (<b>a</b>) The curved actuators in the rear are bent. (<b>b</b>) The inflatable actuators of the left expandable actuators are inflated and expanded. (<b>c</b>) The inflatable actuators of the front are inflated and bent. (<b>d</b>) The curved actuators in the rear are detached from the ground. (<b>e</b>) The actuators of the left expandable are deflated under negative pressure. (<b>f</b>) The curved actuators of the front are detached from the ground.</p>
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17 pages, 1771 KiB  
Article
Predicting Sensory and Affective Tactile Perception from Physical Parameters Obtained by Using a Biomimetic Multimodal Tactile Sensor
by Toshiki Ikejima, Koji Mizukoshi and Yoshimune Nonomura
Sensors 2025, 25(1), 147; https://doi.org/10.3390/s25010147 - 30 Dec 2024
Viewed by 610
Abstract
Tactile perception plays a crucial role in the perception of products and consumer preferences. This perception process is structured in hierarchical layers comprising a sensory layer (soft and smooth) and an affective layer (comfort and luxury). In this study, we attempted to predict [...] Read more.
Tactile perception plays a crucial role in the perception of products and consumer preferences. This perception process is structured in hierarchical layers comprising a sensory layer (soft and smooth) and an affective layer (comfort and luxury). In this study, we attempted to predict the evaluation score of sensory and affective tactile perceptions of materials using a biomimetic multimodal tactile sensor that mimics the active touch behavior of humans and measures physical parameters such as force, vibration, and temperature. We conducted sensory and affective descriptor evaluations on 32 materials, including cosmetics, textiles, and leather. Using the physical parameters obtained by the biomimetic multimodal tactile sensor as explanatory variables, we predicted the scores of the sensory and affective descriptors in 10 regression models. The bagging regressor demonstrated the best performance, achieving a coefficient of determination (R2) of >0.6 for fourteen of nineteen sensory and eight of twelve affective descriptors. The present model exhibited particularly high prediction accuracy for sensory descriptors such as “moist” and “elastic”, and for affective descriptors such as “pleasant” and “like”. These findings suggest a method to support efficient tactile design in product development across various industries by predicting tactile descriptor scores using physical parameters from a biomimetic tactile sensor. Full article
(This article belongs to the Section Wearables)
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<p>Overview of the Toccare system and biomimetic multimodal tactile sensor. (<b>A</b>) Experimental apparatus, (<b>B</b>) measuring mechanism, and (<b>C</b>) schematic of the BioTac finger-shaped tactile sensor.</p>
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<p>Variation in physical parameters for materials. Gray zone is basic range measurement range. Each dot represents the score of a single material.</p>
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<p>Prediction model for the representative sensory descriptors: (<b>A</b>) slimy, (<b>B</b>) soggy, (<b>C</b>) bumpy, and (<b>D</b>) warm. Blue circles indicate training data, and red crosses indicate test data.</p>
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<p>Prediction model for the representative affective descriptors: (<b>A</b>) unpleasant, (<b>B</b>) interest, (<b>C</b>) slight warmth, and (<b>D</b>) delicate. Blue circles indicate training data, and red crosses indicate test data.</p>
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29 pages, 5099 KiB  
Article
Configurable Multi-Layer Perceptron-Based Soft Sensors on Embedded Field Programmable Gate Arrays: Targeting Diverse Deployment Goals in Fluid Flow Estimation
by Tianheng Ling, Chao Qian, Theodor Mario Klann, Julian Hoever, Lukas Einhaus and Gregor Schiele
Sensors 2025, 25(1), 83; https://doi.org/10.3390/s25010083 - 26 Dec 2024
Viewed by 434
Abstract
This study presents a comprehensive workflow for developing and deploying Multi-Layer Perceptron (MLP)-based soft sensors on embedded FPGAs, addressing diverse deployment objectives. The proposed workflow extends our prior research by introducing greater model adaptability. It supports various configurations—spanning layer counts, neuron counts, and [...] Read more.
This study presents a comprehensive workflow for developing and deploying Multi-Layer Perceptron (MLP)-based soft sensors on embedded FPGAs, addressing diverse deployment objectives. The proposed workflow extends our prior research by introducing greater model adaptability. It supports various configurations—spanning layer counts, neuron counts, and quantization bitwidths—to accommodate the constraints and capabilities of different FPGA platforms. The workflow incorporates a custom-developed, open-source toolchain ElasticAI.Creator that facilitates quantization-aware training, integer-only inference, automated accelerator generation using VHDL templates, and synthesis alongside performance estimation. A case study on fluid flow estimation was conducted on two FPGA platforms: the AMD Spartan-7 XC7S15 and the Lattice iCE40UP5K. For precision-focused and latency-sensitive deployments, a six-layer, 60-neuron MLP accelerator quantized to 8 bits on the XC7S15 achieved an MSE of 56.56, an MAPE of 1.61%, and an inference latency of 23.87 μs. Moreover, for low-power and energy-constrained deployments, a five-layer, 30-neuron MLP accelerator quantized to 8 bits on the iCE40UP5K achieved an inference latency of 83.37 μs, a power consumption of 2.06 mW, and an energy consumption of just 0.172 μJ per inference. These results confirm the workflow’s ability to identify optimal FPGA accelerators tailored to specific deployment requirements, achieving a balanced trade-off between precision, inference latency, and energy efficiency. Full article
(This article belongs to the Section Intelligent Sensors)
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<p>General system architecture of soft sensors.</p>
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<p>Architecture of an MLP model.</p>
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<p>Block Diagram of the generated MLP accelerator.</p>
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<p>Workflow of end-to-end deployment.</p>
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<p>Elastic Node V5 (<b>left</b>) and its schematic diagram (<b>right</b>).</p>
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<p>Elastic Node V5 SE (<b>left</b>) and its schematic diagram (<b>right</b>).</p>
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<p>Visualization of three datasets (<span class="html-italic">DS1</span>, <span class="html-italic">DS2</span>, and <span class="html-italic">DS3</span>).</p>
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<p>On Dataset <span class="html-italic">DS1</span>: Performance of FP32 models with varying configurations.</p>
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<p>On Dataset <span class="html-italic">DS2</span>: Performance of FP32 models with varying configurations.</p>
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<p>On Dataset <span class="html-italic">DS3</span>: Performance of FP32 models with varying configurations.</p>
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<p>MSE distribution of quantized models with varying configurations on dataset <span class="html-italic">DS1</span>.</p>
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<p>Performance of best-precise 8-bit quantized models for each configuration.</p>
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<p>Percentage difference in MSE across various model configurations and bitwidths on <span class="html-italic">DS1</span>.</p>
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<p>Performance of best-precise 6-bit quantized models for each configuration.</p>
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<p>Performance of best-precise 4-bit quantized models for each configuration.</p>
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<p>Resource usage on XC7S15 across model configurations on dataset <span class="html-italic">DS1</span>.</p>
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<p>Resource usage on iCE40UP5K across model configurations on dataset <span class="html-italic">DS1</span>.</p>
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<p>Multiplier difference (the ratio of the energy usage of accelerators on the XC7S15 to those on the iCE40UP5K) in energy consumption across varying deployable configurations on Dataset <span class="html-italic">DS1</span>.</p>
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14 pages, 3038 KiB  
Article
Authenticity Verification of Commercial Poppy Seed Oil Using FT-IR Spectroscopy and Multivariate Classification
by Didem P. Aykas
Appl. Sci. 2024, 14(24), 11517; https://doi.org/10.3390/app142411517 - 10 Dec 2024
Viewed by 687
Abstract
Authenticating poppy seed oil is essential to ensure product quality and prevent economic and health-related fraud. This study developed a non-targeted approach using FT-IR spectroscopy and pattern recognition analysis to verify the authenticity of poppy seed oil. Thirty-nine poppy seed oil samples were [...] Read more.
Authenticating poppy seed oil is essential to ensure product quality and prevent economic and health-related fraud. This study developed a non-targeted approach using FT-IR spectroscopy and pattern recognition analysis to verify the authenticity of poppy seed oil. Thirty-nine poppy seed oil samples were sourced from online stores and local markets in Turkiye. Gas chromatography–Flame Ionization Detector (GC-FID) analysis revealed adulteration in 23% of the samples, characterized by unusual fatty acid composition. Spectra of the oil samples were captured with a portable 5-reflection FT-IR sensor. Soft Independent Model of Class Analogies (SIMCA) was used to create class algorithms, successfully detecting all instances of adulteration. Partial least square regression (PLSR) models were then developed to predict the predominant fatty acid composition, achieving strong external validation performance (RCV = 0.96–0.99). The models exhibited low standard errors of prediction (SEP = 0.03–1.40%) and high predictive reliability (RPD = 2.9–6.1; RER = 8.4–13.1). This rapid, non-destructive method offers a reliable solution for authenticating poppy seed oil and predicting its fatty acid composition, presenting valuable applications for producers and regulatory authorities. This approach aids in regulatory compliance, protection of public health, and strengthening of consumer confidence by ensuring the authenticity of the product. Full article
(This article belongs to the Special Issue Applications of Analytical Chemistry in Food Science)
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<p>Representative raw mid-infrared absorption spectrum of analyzed oil samples in wavelength range 4000–650 cm<sup>−1</sup> range, obtained using portable FT-IR spectrometer. * arbitrary units.</p>
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<p>(<b>a</b>) Three-dimensional (3D) projection plot of Soft Independent Modeling of Class Analogy (SIMCA) calibration model for multiple class approach applied to the spectral data of commercial poppy seed oil samples acquired with a portable FT-IR unit. (<b>b</b>) SIMCA discriminating power plot based on the FT-IR spectra of authentic and tainted poppy seed oil samples using a portable FT-IR unit. * arbitrary units. (<b>c</b>) SIMCA 3D projection plot for the external validation set. (<b>d</b>) Three-dimensional projection plot of SIMCA calibration model for single class approach applied to the spectral data of commercial poppy seed oil samples acquired with a portable FT-IR unit. Brown dots represent authentic poppy seed oil samples, red dots represent adulterated poppy seed oil samples, and green dots represent common adulterants.</p>
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28 pages, 3609 KiB  
Article
Type-2 Neutrosophic Markov Chain Model for Subject-Independent Sign Language Recognition: A New Uncertainty–Aware Soft Sensor Paradigm
by Muslem Al-Saidi, Áron Ballagi, Oday Ali Hassen and Saad M. Saad
Sensors 2024, 24(23), 7828; https://doi.org/10.3390/s24237828 - 7 Dec 2024
Viewed by 503
Abstract
Uncertainty-aware soft sensors in sign language recognition (SLR) integrate methods to quantify and manage the uncertainty in their predictions. This is particularly crucial in SLR due to the variability in sign language gestures and differences in individual signing styles. Managing uncertainty allows the [...] Read more.
Uncertainty-aware soft sensors in sign language recognition (SLR) integrate methods to quantify and manage the uncertainty in their predictions. This is particularly crucial in SLR due to the variability in sign language gestures and differences in individual signing styles. Managing uncertainty allows the system to handle variations in signing styles, lighting conditions, and occlusions more effectively. While current techniques for handling uncertainty in SLR systems offer significant benefits in terms of improved accuracy and robustness, they also come with notable disadvantages. High computational complexity, data dependency, scalability issues, sensor and environmental limitations, and real-time constraints all pose significant hurdles. The aim of the work is to develop and evaluate a Type-2 Neutrosophic Hidden Markov Model (HMM) for SLR that leverages the advanced uncertainty handling capabilities of Type-2 neutrosophic sets. In the suggested soft sensor model, the Foot of Uncertainty (FOU) allows Type-2 Neutrosophic HMMs to represent uncertainty as intervals, capturing the range of possible values for truth, falsity, and indeterminacy. This is especially useful in SLR, where gestures can be ambiguous or imprecise. This enhances the model’s ability to manage complex uncertainties in sign language gestures and mitigate issues related to model drift. The FOU provides a measure of confidence for each recognition result by indicating the range of uncertainty. By effectively addressing uncertainty and enhancing subject independence, the model can be integrated into real-life applications, improving interactions, learning, and accessibility for the hearing-impaired. Examples such as assistive devices, educational tools, and customer service automation highlight its transformative potential. The experimental evaluation demonstrates the superiority of the Type-2 Neutrosophic HMM over the Type-1 Neutrosophic HMM in terms of accuracy for SLR. Specifically, the Type-2 Neutrosophic HMM consistently outperforms its Type-1 counterpart across various test scenarios, achieving an average accuracy improvement of 10%. Full article
(This article belongs to the Special Issue Computer Vision and Smart Sensors for Human-Computer Interaction)
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<p>Study context: (<b>a</b>) sign categories, (<b>b</b>) sign characteristics, (<b>c</b>) sign detection techniques, (<b>d</b>) sign data acquisition approaches, and (<b>e</b>) sign classification conditions [<a href="#B4-sensors-24-07828" class="html-bibr">4</a>]. The red circles highlight the key focus areas of our study within the hierarchy of sign language recognition.</p>
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<p>(<b>Left</b>) Type-1 neutrosophic truth <math display="inline"><semantics> <mrow> <mi>T</mi> <mo>(</mo> <mi>N</mi> <mo>)</mo> </mrow> </semantics></math>, indeterminacy <math display="inline"><semantics> <mrow> <mi>I</mi> <mo>(</mo> <mi>N</mi> <mo>)</mo> </mrow> </semantics></math>, and falsity membership functions <math display="inline"><semantics> <mrow> <mi>F</mi> <mo>(</mo> <mi>N</mi> <mo>)</mo> </mrow> </semantics></math>. (<b>Right</b>) Type-2 neutrosophic set membership functions. The blurred region in T2NS provides two extra memberships for truth, indeterminacy, and falsify membership functions TM, IM, and FM. The two extra memberships are <math display="inline"><semantics> <mrow> <msub> <mrow> <mi>N</mi> </mrow> <mrow> <mi>l</mi> </mrow> </msub> </mrow> </semantics></math> and <math display="inline"><semantics> <mrow> <msub> <mrow> <mi>N</mi> </mrow> <mrow> <mi>r</mi> </mrow> </msub> </mrow> </semantics></math>; <math display="inline"><semantics> <mrow> <mi>l</mi> </mrow> </semantics></math> and <math display="inline"><semantics> <mrow> <mi>r</mi> </mrow> </semantics></math> are left and right shifts [<a href="#B7-sensors-24-07828" class="html-bibr">7</a>].</p>
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<p>Some English alphabet in American Sign Language.</p>
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<p>Linear trapezoidal neutrosophic membership function.</p>
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<p>Graphical representation of Type-2 neutrosophic membership function [<a href="#B8-sensors-24-07828" class="html-bibr">8</a>].</p>
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<p>An interval Type-2 trapezoidal neutrosophic number [<a href="#B8-sensors-24-07828" class="html-bibr">8</a>].</p>
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<p>Recorded ArSL alphabet.</p>
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<p>Preprocessing techniques for enhancing sign language image quality.</p>
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29 pages, 2345 KiB  
Article
Signal Processing for Transient Flow Rate Determination: An Analytical Soft Sensor Using Two Pressure Signals
by Faras Brumand-Poor, Tim Kotte, Enrico Gaspare Pasquini and Katharina Schmitz
Signals 2024, 5(4), 812-840; https://doi.org/10.3390/signals5040045 - 2 Dec 2024
Viewed by 699
Abstract
Accurate knowledge of the flow rate is essential for hydraulic systems, enabling the calculation of hydraulic power when combined with pressure measurements. These data are crucial for applications such as predictive maintenance. However, most flow rate sensors in fluid power systems operate invasively, [...] Read more.
Accurate knowledge of the flow rate is essential for hydraulic systems, enabling the calculation of hydraulic power when combined with pressure measurements. These data are crucial for applications such as predictive maintenance. However, most flow rate sensors in fluid power systems operate invasively, disrupting the flow and producing inaccurate results, especially under transient conditions. Utilizing pressure transducers represents a non-invasive soft sensor approach since no physical flow rate sensor is used to determine the flow rate. Usually, this approach relies on the Hagen–Poiseuille (HP) law, which is limited to steady and incompressible flow. This paper introduces a novel soft sensor with an analytical model for transient, compressible pipe flow based on two pressure signals. The model is derived by solving fundamental fluid equations in the Laplace domain and converting them back to the time domain. Using the four-pole theorem, this model contains a relationship between the pressure difference and the flow rate. Several unsteady test cases are investigated and compared to a steady soft sensor based on the HP law, highlighting our soft sensor’s promising capability. It exhibits an overall error of less than 0.15% for the investigated test cases in a distributed-parameter simulation, whereas the HP-based sensor shows errors in the double-digit range. Full article
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Graphical abstract

Graphical abstract
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<p>Laminar velocity profiles for various Womersley numbers ranging from 1.5 to 30 with a phase angle of 90° (right side) and laminar velocity profiles for various phase angles ranging from 90° to 190° with a Womersley number of 30.</p>
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<p>Flowchart of the derivation of the soft sensor equations.</p>
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<p>Logarithm of absolute of weighting function <math display="inline"><semantics> <msubsup> <mi>W</mi> <mn>1</mn> <mo>*</mo> </msubsup> </semantics></math> for real and imaginary arguments for fixed dissipation number.</p>
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<p>Weighting functions featuring only residues of negative real poles (incompressible solution) and residues of all poles (compressible solution).</p>
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<p>Weighting functions featuring only residues of negative real poles (incompressible solution) and residues of all poles (compressible solution).</p>
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<p>ILT using residue theorem for both weighting functions.</p>
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<p>Position of the poles of <math display="inline"><semantics> <mrow> <msubsup> <mi>W</mi> <mrow> <mn>1</mn> </mrow> <mo>*</mo> </msubsup> <mrow> <mo>(</mo> <mi>ζ</mi> <mo>)</mo> </mrow> </mrow> </semantics></math> for various <math display="inline"><semantics> <mrow> <mi>D</mi> <mi>n</mi> </mrow> </semantics></math>.</p>
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<p>The 1 Hz sine wave pressure boundary at the 50 bar level.</p>
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<p>The 100 Hz sine wave pressure boundary at the 50 bar level.</p>
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<p>The 1000 Hz sine wave pressure boundary at the 50 bar level.</p>
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<p>Sum of sine waves with 1 Hz, 10 Hz, 20 Hz, and 40 Hz pressure boundaries at 50 bar level.</p>
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<p>Sum of sine waves with 10 Hz, 100 Hz, 200 Hz, and 400 Hz pressure boundaries at 50 bar level.</p>
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<p>Sawtooth pressure boundary at 50 bar level.</p>
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<p>Step function pressure boundary at 50 bar level.</p>
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2999 KiB  
Proceeding Paper
Intelligent Fault Diagnosis of Centrifugal Pump Valves in Microbreweries
by Marcio Rafael Buzoli, Matheus Luis Despirito, Fabio Romano Lofrano Dotto, Pedro de Oliveira Conceição Junior and Andre Luis Dias
Eng. Proc. 2024, 82(1), 65; https://doi.org/10.3390/ecsa-11-20360 - 25 Nov 2024
Viewed by 86
Abstract
The brewing industry is expanding with the rise of many small breweries. These are typically small and medium-sized enterprises producing a few hectoliters of beer per batch, often with limited investment capacity for equipment. Centrifugal pumps play a crucial role in microbreweries, facilitating [...] Read more.
The brewing industry is expanding with the rise of many small breweries. These are typically small and medium-sized enterprises producing a few hectoliters of beer per batch, often with limited investment capacity for equipment. Centrifugal pumps play a crucial role in microbreweries, facilitating the movement of wort throughout various stages of the brewing process. Failures in these systems, such as valve positioning issues or blockages, can lead to longer production times, increased energy consumption, and potential quality issues. This study explores a soft sensor approach for developing IFDs (Intelligent Fault Detection systems) by using pump drive data—current, torque, and power factor—without the need for additional sensors. Data were collected via a managed switch, and models were trained using Support Vector Machine and Multilayer Perceptron algorithms. The results indicate that this IFD method holds great potential for enhancing automation and maintenance in small breweries. Full article
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<p>Control panel of the brewing pilot plant.</p>
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<p>Data attributes from a PROFINET data packet: a = Current Speed, b = Electric Current, c = Motor Torque, d = Power Factor.</p>
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<p>Behavior of the variables during 1 s of sampling under normal conditions at 1000 RPM.</p>
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<p>Behavior of the variables during 1 s of sampling with inlet blocked at 1000 RPM.</p>
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<p>Behavior of the variables during 1 s of sampling with outlet blocked at 1000 RPM.</p>
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<p>Principal Component Analysis.</p>
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22 pages, 8930 KiB  
Article
Design, Control, and Testing of a Multifunctional Soft Robotic Gripper
by Ana Correia, Tiago Charters, Afonso Leite, Francisco Campos, Nuno Monge, André Rocha and Mário J. G. C. Mendes
Actuators 2024, 13(12), 476; https://doi.org/10.3390/act13120476 - 25 Nov 2024
Viewed by 911
Abstract
This paper proposes a multifunctional soft robotic gripper for a Dobot robot to handle sensitive products. The gripper is based on pneumatic network (PneuNet) bending actuators. In this study, two different models of PneuNet actuators have been studied, designed, simulated, experimentally tested, and [...] Read more.
This paper proposes a multifunctional soft robotic gripper for a Dobot robot to handle sensitive products. The gripper is based on pneumatic network (PneuNet) bending actuators. In this study, two different models of PneuNet actuators have been studied, designed, simulated, experimentally tested, and validated using two different techniques (3D printing and molding) and three different materials: FilaFlex 60A (3D-printed), Elastosil M4601, and Dragonskin Fast 10 silicones (with molds). A new soft gripper design for the Dobot robot is presented, and a new design/production approach with molds is proposed to obtain the gripper’s PneuNet multifunctional actuators. It also describes a new control approach that is used to control the PneuNet actuators and gripper function, using compressed air generated by a small compressor/air pump, a pressure sensor, a mini valve, etc., and executing on a low-cost controller board—Arduino UNO. This paper presents the main simulation and experimental results of this research study. Full article
(This article belongs to the Special Issue Soft Actuators and Robotics—2nd Edition)
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<p>PneuNet chamber (<b>a</b>) before and (<b>b</b>) after inflation (adapted from [<a href="#B17-actuators-13-00476" class="html-bibr">17</a>]).</p>
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<p>PneuNet actuators modeled: (<b>a</b>) type 1, inspired by [<a href="#B19-actuators-13-00476" class="html-bibr">19</a>] and made with Elastosil and DragonSkin Fast 10 (using molds) and with Filaflex 60A filament by FDM; (<b>b</b>) type 2, inspired by [<a href="#B20-actuators-13-00476" class="html-bibr">20</a>], made with Filaflex 60A filament by FDM.</p>
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<p>PneuNet actuators of type 1 fabricated with molds (<b>a</b>) made with DragonSkin Fast 10 silicone and (<b>b</b>) made with Elastosil M4601 A/B silicone.</p>
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<p>FDM-printed mold for PneuNet actuators of type 1: (<b>a</b>) half of the mold; (<b>b</b>) top half of the mold along with the PneuNet actuator molded with DragonSkin Fast 10 and inner core; and (<b>c</b>) 3D model of the mold and inner core.</p>
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<p>PneuNet actuators fabricated: (<b>a</b>) type 1, inspired by [<a href="#B19-actuators-13-00476" class="html-bibr">19</a>], and (<b>b</b>) type 2, inspired by [<a href="#B20-actuators-13-00476" class="html-bibr">20</a>]. Both actuators were 3D-printed with FilaFlex 60A filament by FDM.</p>
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<p>PneuNet actuators of type 1 mounted on the PLA FDM-printed coupling base. (<b>a</b>) fabricated with FDM using Filaflex 60A filament and (<b>b</b>) made with DragonSkin Fast 10 silicone by molding, (<b>c</b>) gripper coupling base, and (<b>d</b>) Dobot robot with soft gripper installed.</p>
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<p>Pneumatic circuit that regulates air flow in/out of the soft gripper.</p>
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<p>Electronic circuit of the control system that drives gripper actions.</p>
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<p>PneuNet actuators of type 1 FEM deformation results obtained for (<b>a</b>) Elastosil M4601 A/B silicone and (<b>b</b>) DragonSkin Fast 10 silicone for 0 kPa input pressure.</p>
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<p>PneuNet actuators of type 1 FEM deformation results were obtained for (<b>a</b>) Elastosil M4601 A/B silicone and (<b>b</b>) DragonSkin Fast 10 silicone for 40 kPa (0.4 bar) input pressure.</p>
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<p>PneuNet actuator of type 1 made of Elastosil M4601 A/B silicone comparison for 100 kPa (1 bar) input pressure: (<b>a</b>) FEM model with measured angle and (<b>b</b>) real actuator screenshot, made with the Kinovea software, with a measured angle.</p>
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<p>PneuNet actuator of type 1, made of DragonSkin Fast 10 silicone, comparison for 40 kPa (0.4 bar) input pressure: (<b>a</b>) FEM model with measured angle and (<b>b</b>) real actuator screenshot, made with the Kinovea software, with a measured angle.</p>
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<p>Bending angle vs. pressure for the Elastosil M6401 A/B type 1 actuator. Experimental data and simulation results.</p>
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<p>Bending angle vs. pressure for the Dragonskin Fast 10 type 1 actuator. Experimental data and simulation results.</p>
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<p>FEM deformation results of PneuNet actuators obtained for (<b>a</b>) type 1 and (<b>b</b>) type 2, both for Filaflex 60A material obtained by FDM, and no input pressure.</p>
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<p>FEM deformation results of PneuNet actuators obtained for (<b>a</b>) type 1 and (<b>b</b>) type 2, both for Filaflex 60A material obtained by FDM, and 180 kPa (1.8 bar) input pressure.</p>
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<p>PneuNet actuator of type 1, made of Filaflex 60A FDM filament, comparison for 250 kPa (2.5 bar) input pressure: (<b>a</b>) FEM model with measured angle and (<b>b</b>) real actuator screenshot, made with the Kinovea software, with a measured angle.</p>
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<p>PneuNet actuator of type 2, made of Filaflex 60A FDM filament, comparison for 180 kPa (1.8 bar) input pressure: (<b>a</b>) FEM model with a measured angle and (<b>b</b>) real actuator screenshot, made with the Kinovea software, with a measured angle.</p>
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<p>Bending angle vs. pressure for the Filaflex 60A type 1 actuator. Experimental data and simulation results.</p>
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<p>Bending angle vs. pressure for the Filaflex 60A type 2 actuator. Experimental data and simulation results.</p>
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<p>Results with a PI controller (<b>a</b>) and with an on/off controller (<b>b</b>).</p>
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14 pages, 4024 KiB  
Article
A Multivariable Probability Density-Based Auto-Reconstruction Bi-LSTM Soft Sensor for Predicting Effluent BOD in Wastewater Treatment Plants
by Wenting Li, Yonggang Li, Dong Li and Jiayi Zhou
Sensors 2024, 24(23), 7508; https://doi.org/10.3390/s24237508 - 25 Nov 2024
Viewed by 512
Abstract
The precise detection of effluent biological oxygen demand (BOD) is crucial for the stable operation of wastewater treatment plants (WWTPs). However, existing detection methods struggle to meet the evolving drainage standards and management requirements. To address this issue, this paper proposed a multivariable [...] Read more.
The precise detection of effluent biological oxygen demand (BOD) is crucial for the stable operation of wastewater treatment plants (WWTPs). However, existing detection methods struggle to meet the evolving drainage standards and management requirements. To address this issue, this paper proposed a multivariable probability density-based auto-reconstruction bidirectional long short-term memory (MPDAR-Bi-LSTM) soft sensor for predicting effluent BOD, enhancing the prediction accuracy and efficiency. Firstly, the selection of appropriate auxiliary variables for soft-sensor modeling is determined through the calculation of k-nearest-neighbor mutual information (KNN-MI) values between the global process variables and effluent BOD. Subsequently, considering the existence of strong interactions among different reaction tanks, a Bi-LSTM neural network prediction model is constructed with historical data. Then, a multivariate probability density-based auto-reconstruction (MPDAR) strategy is developed for adaptive updating of the prediction model, thereby enhancing its robustness. Finally, the effectiveness of the proposed soft sensor is demonstrated through experiments using the dataset from Benchmark Simulation Model No.1 (BSM1). The experimental results indicate that the proposed soft sensor not only outperforms some traditional models in terms of prediction performance but also excels in avoiding ineffective model reconstructions in scenarios involving complex dynamic wastewater treatment conditions. Full article
(This article belongs to the Section Physical Sensors)
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<p>The structural diagrams of LSTM and Bi-LSTM.</p>
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<p>The algorithm flowchart of the proposed MPDAR-Bi-LSTM soft sensor.</p>
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<p>The basic structure of the BSM1 plant.</p>
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<p>The curves of process variables in different stages of the BSM1 plant. (<b>a</b>) Original inflow of the plant; (<b>b</b>) input of reaction tank 1; (<b>c</b>) output of reaction tank 1; (<b>d</b>) output of reaction tank 2; (<b>e</b>) output of reaction tank 3; (<b>f</b>) output of reaction tank 4; (<b>g</b>) output of reaction tank 5; (<b>h</b>) input of the secondary settler; (<b>i</b>) underflow of the secondary settler; (<b>j</b>) external recycle; (<b>k</b>) outflow of the plant.</p>
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<p>The KNN-MI values between each process variable and effluent BOD.</p>
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<p>Prediction results of effluent BOD in the WWTP under (<b>a</b>) sunny days, (<b>b</b>) rainy days, and (<b>c</b>) rainstorm days. (For interpretation of the colors in this figure, the reader is referred to the web version of this article.)</p>
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22 pages, 8009 KiB  
Article
Modeling of Spiral Wound Membranes for Gas Separations—Part IV: Real-Time Monitoring Based on Detailed Phenomenological Model
by Marília Caroline C. de Sá, Diego Q. F. de Menezes, Tahyná B. Fontoura, Luiz Felipe de O. Campos, Thiago K. Anzai, Fábio C. Diehl, Pedro H. Thompson and José Carlos Pinto
Processes 2024, 12(11), 2597; https://doi.org/10.3390/pr12112597 - 19 Nov 2024
Viewed by 767
Abstract
The present study presents, for the first time, the real-time monitoring of an actual spiral-wound membrane unit used for CO2 removal from natural gas in an actual industrial offshore platform, utilizing a detailed phenomenological model. An Object-Oriented Programming (OOP) paradigm was employed [...] Read more.
The present study presents, for the first time, the real-time monitoring of an actual spiral-wound membrane unit used for CO2 removal from natural gas in an actual industrial offshore platform, utilizing a detailed phenomenological model. An Object-Oriented Programming (OOP) paradigm was employed to simulate the offshore membrane separation unit, accounting for the diverse levels of the membrane separation setup. A parameter estimation procedure was implemented to fit the phenomenological model to the real industrial data in real-time, for the first time. In addition, estimated permeance parameters and calculated unmeasured variables (soft sensor) were used for monitoring Key Performance Indicators (KPIs), such as membrane selectivity, dew point temperature, and hydrocarbon loss. Finally, a reparametrization of the parameters was implemented to improve the robustness of the optimization procedure. Thus, the model variables presented good adjustments to the data, indicating the satisfactory performance of the estimation. Consequently, the good accuracy of the model provided reliable information to the soft sensors and KPIs. Full article
(This article belongs to the Section Process Control and Monitoring)
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<p>Configuration of the actual membrane separation unit of an offshore field (adapted from de Menezes et al. [<a href="#B24-processes-12-02597" class="html-bibr">24</a>]).</p>
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<p>Schematic representation of an elemental volume of the spiral-wound membrane leaf.</p>
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<p>Schematic representation of the algorithm for dew point temperature calculation.</p>
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<p>Flowchart of monitoring steps.</p>
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<p>The sequence of reparametrization and relationship between parameters.</p>
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<p>Permeation mechanism and the definition of permeability and selectivity.</p>
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<p>Dew point temperature monitoring and its effects on the residue flow rate.</p>
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<p>Estimation of permeances before reparametrization—composition of methane (<math display="inline"><semantics> <msub> <mi mathvariant="normal">C</mi> <mn>1</mn> </msub> </semantics></math>) and <math display="inline"><semantics> <msub> <mi>CO</mi> <mn>2</mn> </msub> </semantics></math> in the residue stream.</p>
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<p>Estimation of permeances after parametrization—composition of methane (<math display="inline"><semantics> <msub> <mi mathvariant="normal">C</mi> <mn>1</mn> </msub> </semantics></math>) and <math display="inline"><semantics> <msub> <mi>CO</mi> <mn>2</mn> </msub> </semantics></math> in the residue stream.</p>
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<p>Selectivity and HC loss for the simulated case (HC loss).</p>
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<p>Permeance of <math display="inline"><semantics> <msub> <mi mathvariant="normal">C</mi> <mn>1</mn> </msub> </semantics></math> and <math display="inline"><semantics> <msub> <mi>CO</mi> <mn>2</mn> </msub> </semantics></math> for the simulated case (HC loss).</p>
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<p>Real-time monitoring of selectivity in a real membrane separation unit of an actual industrial offshore platform.</p>
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<p>Objective function and computational time of the parameter estimation procedure for real-time monitoring in a real membrane separation unit of an actual industrial offshore platform.</p>
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<p>Real-time monitoring of methane (<math display="inline"><semantics> <msub> <mi mathvariant="normal">C</mi> <mn>1</mn> </msub> </semantics></math>) and <math display="inline"><semantics> <msub> <mi>CO</mi> <mn>2</mn> </msub> </semantics></math> composition in the residue stream in a real membrane separation unit of an actual offshore platform.</p>
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<p>Real-time monitoring of dew point temperature in the residue stream and hydrocarbon loss in a real membrane separation unit of an actual industrial offshore platform.</p>
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<p>Real-time monitoring of residue and permeate temperatures in a real membrane separation unit of an actual industrial offshore platform.</p>
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<p>Correlation matrix between permeances and response variables.</p>
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21 pages, 5645 KiB  
Article
Design, Testing, and Validation of a Soft Robotic Sensor Array Integrated with Flexible Electronics for Mapping Cardiac Arrhythmias
by Abdellatif Ait Lahcen, Michael Labib, Alexandre Caprio, Mohsen Annabestani, Lina Sanchez-Botero, Weihow Hsue, Christopher F. Liu, Simon Dunham and Bobak Mosadegh
Micromachines 2024, 15(11), 1393; https://doi.org/10.3390/mi15111393 - 18 Nov 2024
Viewed by 994
Abstract
Cardiac mapping is a crucial procedure for diagnosing and treating cardiac arrhythmias. Still, current clinical techniques face limitations including insufficient electrode coverage, poor conformability to complex heart chamber geometries, and high costs. This study explores the design, testing, and validation of a 64-electrode [...] Read more.
Cardiac mapping is a crucial procedure for diagnosing and treating cardiac arrhythmias. Still, current clinical techniques face limitations including insufficient electrode coverage, poor conformability to complex heart chamber geometries, and high costs. This study explores the design, testing, and validation of a 64-electrode soft robotic catheter that addresses these challenges in cardiac mapping. A dual-layer flexible printed circuit board (PCB) was designed and integrated with sensors into a soft robotic sensor array (SRSA) assembly. Design considerations included flex PCB layout, routing, integration, conformity to heart chambers, sensor placement, and catheter durability. Rigorous SRSA in vitro testing evaluated the burst/leakage pressure, block force for electrode contact, mechanical integrity, and environmental resilience. For in vivo validation, a porcine model was used to demonstrate the successful deployment, conformability, and acquisition of electrograms in both the ventricles and atria. This catheter-deployable SRSA represents a meaningful step towards translating the integration of soft robotic actuators and stretchable electronics for clinical use, showcasing the unique mechanical and electrical performance that these designs enable. The high-density electrode array enabled rapid 2 s data acquisition with detailed spatial and temporal resolution, as illustrated by the clear and consistent cardiac signals recorded across all electrodes. The future of this work will lie in enabling high-density, anatomically conformable devices for detailed cardiac mapping to guide ablation therapy and other interventions. Full article
(This article belongs to the Section B:Biology and Biomedicine)
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<p>Schematic illustration of the four-legged sensor array assembly.</p>
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<p>The SRSA device’s integration steps start with (<b>i</b>) SRSA distal hub insertion into the Oscor catheter inlet, (<b>ii</b>) the insertion of the 6.5 Fr inner catheter into the outer 13.8 Fr catheter, (<b>iii</b>) the successful insertion of the four-legged SRSA into the catheter, (<b>iv</b>) the deployment of the four-legged SRSA, and (<b>v</b>) the whole device showing the four-legged SRSA integrated with the catheter.</p>
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<p>Custom-made rigid PCB board. (<b>a</b>) The KiCAD design of the rigid PCB. (<b>b</b>) The custom-made rigid PCB used to connect the SRSA with the National Instruments readout.</p>
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<p>Soft robotic sensor array assembly that shows the final catheter-delivered design.</p>
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<p>Bench testing performance: (<b>a</b>) designed 3D printed mock, (<b>b</b>) experiment setup, (<b>c</b>) force vs electrode location on the linear actuator, (<b>d</b>) force vs actuator location by the width of PVA, and (<b>e</b>) linear actuator and location of electrodes shown as red boxes.</p>
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<p>(<b>a</b>) An evaluation of conformability for multiple actuations using a deflection analysis (scale bar is 1 cm), (<b>b</b>) the effect of the actuation on the radius of curvature, (<b>c</b>) the actuator’s block force before (peach color) and after (green color) the durability tests (<b>d</b>) the electrical response measurements for the 16 electrodes on the actuator before and after 100 actuations.</p>
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<p>(<b>a</b>) Electrical response measurements between (<b>i</b>) neighboring and (<b>ii</b>) cross electrodes, (<b>b</b>) flex PCB/extender junction, (<b>c</b>) (<b>i</b>) linear actuator immersed in a saline medium under 37 °C for 7 days (<b>ii</b>) flex PCB/extender junction immersed in a saline medium under 37 °C for 1 day, (<b>d</b>) electrical resistance measurements for the 16 electrodes on the actuators at dry conditions, (after 1 and 7 days in saline at 37 °C, and (<b>e</b>) electrical response measurements for the 16 electrodes on flex PCB/extender at dry conditions and after days in saline at 37 °C.</p>
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<p>(<b>a</b>) (<b>i</b>) flex PCB/extender pads before break; (<b>ii</b>) flex PCB/extender pads after break. (<b>b</b>) Load-extension curve for tensile strength of flex PCB/extender junction pads.</p>
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<p>Conformability in cardiac chambers. (<b>A</b>) 3D model of catheter delivery progressing from the (<b>i</b>) inferior vena cava (IVC), (<b>ii</b>) left atrium, and (<b>iii</b>) left ventricle. (<b>B</b>) Sensor-tissue contact inside the heart location using fluoroscopy after deployment. (<b>C</b>) ICE catheter image that shows deployment of SRSA device in LV heart chamber. (<b>D</b>) Electrograms acquired while device was in left ventricle. (<b>E</b>) Electrograms acquired with one single actuator. (<b>F</b>) Phase shift between electrodes at Actuator 1 and 3. (<b>G</b>) Signal to noise ratio analysis for acquired electrograms.</p>
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16 pages, 8192 KiB  
Perspective
Embedding AI-Enabled Data Infrastructures for Sustainability in Agri-Food: Soft-Fruit and Brewery Use Case Perspectives
by Milan Markovic, Andy Li, Tewodros Alemu Ayall, Nicholas J. Watson, Alexander L. Bowler, Mel Woods, Peter Edwards, Rachael Ramsey, Matthew Beddows, Matthias Kuhnert and Georgios Leontidis
Sensors 2024, 24(22), 7327; https://doi.org/10.3390/s24227327 - 16 Nov 2024
Viewed by 1140
Abstract
The agri-food sector is undergoing a comprehensive transformation as it transitions towards net zero. To achieve this, fundamental changes and innovations are required, including changes in how food is produced and delivered to customers, new technologies, data and physical infrastructures, and algorithmic advancements. [...] Read more.
The agri-food sector is undergoing a comprehensive transformation as it transitions towards net zero. To achieve this, fundamental changes and innovations are required, including changes in how food is produced and delivered to customers, new technologies, data and physical infrastructures, and algorithmic advancements. In this paper, we explore the opportunities and challenges of deploying AI-based data infrastructures for sustainability in the agri-food sector by focusing on two case studies: soft-fruit production and brewery operations. We investigate the potential benefits of incorporating Internet of Things (IoT) sensors and AI technologies for improving the use of resources, reducing carbon footprints, and enhancing decision-making. We identify user engagement with new technologies as a key challenge, together with issues in data quality arising from environmental volatility, difficulties in generalising models, including those designed for carbon calculators, and socio-technical barriers to adoption. We highlight and advocate for user engagement, more granular availability of sensor, production, and emissions data, and more transparent carbon footprint calculations. Our proposed future directions include semantic data integration to enhance interoperability, the generation of synthetic data to overcome the lack of real-world farm data, and multi-objective optimisation systems to model the competing interests between yield and sustainability goals. In general, we argue that AI is not a silver bullet for net zero challenges in the agri-food industry, but at the same time, AI solutions, when appropriately designed and deployed, can be a useful tool when operating in synergy with other approaches. Full article
(This article belongs to the Special Issue Application of Sensors Technologies in Agricultural Engineering)
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<p>Temp./humidity sensor outside tunnel.</p>
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<p>Temp./humidity and light sensor inside tunnel.</p>
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<p>Flow meter inside tunnel.</p>
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<p>Fermentation sensor.</p>
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<p>Wireless electricity monitor.</p>
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15 pages, 11324 KiB  
Article
Scalable O(log2n) Dynamics Control for Soft Exoskeletons
by Julian D. Colorado, Diego Mendez, Andres Gomez-Bautista, John E. Bermeo, Catalina Alvarado-Rojas and Fredy Cuellar
Actuators 2024, 13(11), 450; https://doi.org/10.3390/act13110450 - 9 Nov 2024
Viewed by 928
Abstract
Robotic exoskeletons are being actively applied to support the activities of daily living (ADL) for patients with hand motion impairments. In terms of actuation, soft materials and sensors have opened new alternatives to conventional rigid body structures. In this arena, biomimetic soft systems [...] Read more.
Robotic exoskeletons are being actively applied to support the activities of daily living (ADL) for patients with hand motion impairments. In terms of actuation, soft materials and sensors have opened new alternatives to conventional rigid body structures. In this arena, biomimetic soft systems play an important role in modeling and controlling human hand kinematics without the restrictions of rigid mechanical joints while having an entirely deformable body with limitless points of actuation. In this paper, we address the computational limitations of modeling large-scale articulated systems for soft robotic exoskeletons by integrating a parallel algorithm to compute the exoskeleton’s dynamics equations of motion (EoM), achieving a computation with O(log2n) complexity for the highly articulated n degrees of freedom (DoF) running on p processing cores. The proposed parallel algorithm achieves an exponential speedup for n=p=64 DoF while achieving a 0.96 degree of parallelism for n=p=256, which demonstrates the required scalability for controlling highly articulated soft exoskeletons in real time. However, scalability will be bounded by the n=p fraction. Full article
(This article belongs to the Special Issue Actuators and Robots for Biomedical Applications)
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<p>Hardware in-the-loop approach for computing a large-scale exoskeleton’s multi-body dynamics using parallel computing: a virtual model (digital twin) replicates the hand dynamics (blue section), while a real embedded device executes the control mechanisms (yellow section).</p>
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<p>(<b>a</b>) Former rigid-body mechanism reported in our previous work [<a href="#B19-actuators-13-00450" class="html-bibr">19</a>], composed of 3 under-actuated joints connected to a single actuation input driven by a linear actuator. (<b>b</b>) Soft model implemented in SoRoSim©Matlab™ composed of 512 degrees of freedom that emulate flexible bending [<a href="#B28-actuators-13-00450" class="html-bibr">28</a>]. (<b>c</b>) Proposed novel mechanism based on a semi-soft structure driven by compliant joints.</p>
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<p>Parallel EoM calculation following an <math display="inline"><semantics> <mrow> <mi>O</mi> <mo>(</mo> <mi>l</mi> <mi>o</mi> <msub> <mi>g</mi> <mn>2</mn> </msub> <mi>n</mi> <mo>)</mo> </mrow> </semantics></math> computational complexity. The computing steps (<span class="html-italic">e</span>) for the case of <math display="inline"><semantics> <mrow> <mi>n</mi> <mo>=</mo> <mn>8</mn> </mrow> </semantics></math> degrees of freedom (DoF) are depicted. For higher joints (<math display="inline"><semantics> <mrow> <mi>n</mi> <mo>&gt;</mo> <mo>&gt;</mo> </mrow> </semantics></math>), the same <math display="inline"><semantics> <mrow> <mi>O</mi> <mo>(</mo> <mi>l</mi> <mi>o</mi> <msub> <mi>g</mi> <mn>2</mn> </msub> <mi>n</mi> <mo>)</mo> </mrow> </semantics></math> propagation scheme is maintained. On the left, both the spatial velocities (<span class="html-italic">V</span>) and accelerations (<math display="inline"><semantics> <mover accent="true"> <mi>V</mi> <mo>˙</mo> </mover> </semantics></math>) are computed by following a forward propagation. On the right, the spatial forces (<span class="html-italic">F</span>) are calculated in a backward direction. Computing cores are represented by each node.</p>
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<p>(<b>a</b>) Computational time comparison between the serial <math display="inline"><semantics> <mrow> <mi>O</mi> <mo>(</mo> <mi>n</mi> <mo>)</mo> </mrow> </semantics></math> RNE (cf. Algorithm 1) and the parallel <math display="inline"><semantics> <mrow> <mi>O</mi> <mo>(</mo> <mi>l</mi> <mi>o</mi> <msub> <mi>g</mi> <mn>2</mn> </msub> <mi>n</mi> <mo>)</mo> </mrow> </semantics></math> RNE (cf. Algorithm 2). (<b>b</b>) Close-up of the <math display="inline"><semantics> <mrow> <mi>O</mi> <mo>(</mo> <mi>l</mi> <mi>o</mi> <msub> <mi>g</mi> <mn>2</mn> </msub> <mi>n</mi> <mo>)</mo> </mrow> </semantics></math> response of Algorithm 2), including computational time variations depending on the number of trajectory points (<math display="inline"><semantics> <mrow> <mi>p</mi> <mi>t</mi> </mrow> </semantics></math>) defined for the exoskeleton’s therapy motions. For this test, <math display="inline"><semantics> <mrow> <mi>p</mi> <mi>t</mi> </mrow> </semantics></math> was varied from 500 to 2000 trajectory knot points with a fixed step time of <math display="inline"><semantics> <mrow> <mn>0.01</mn> </mrow> </semantics></math> s (platform: Intel<sup>®</sup>Core™i7 processor with 512 GPU NVIDIA Quadro cores).</p>
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<p>Speedup of the proposed <math display="inline"><semantics> <mrow> <mi>O</mi> <mo>(</mo> <mi>l</mi> <mi>o</mi> <msub> <mi>g</mi> <mn>2</mn> </msub> <mi>n</mi> <mo>)</mo> </mrow> </semantics></math> RNE algorithm compared to Amdahl’s law for several degrees of parallelism ranging from <math display="inline"><semantics> <mrow> <mn>0.8</mn> </mrow> </semantics></math> to <math display="inline"><semantics> <mrow> <mn>0.99</mn> </mrow> </semantics></math> (platform: Intel®Core™i7 processor with 512 GPU NVIDIA Quadro cores).</p>
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<p>(<b>a</b>) Ansys<sup>®</sup>simulation for the proposed semi-soft structure driven by the compliant joint mechanism. (<b>b</b>) Computation time for the soft model implemented in SoRoSim©Matlab™.</p>
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<p>HIL-based <math display="inline"><semantics> <mrow> <mi>O</mi> <mo>(</mo> <mi>l</mi> <mi>o</mi> <msub> <mi>g</mi> <mn>2</mn> </msub> <mi>n</mi> <mo>)</mo> </mrow> </semantics></math> response of Algorithm 2, showing computation time variations based on the number of trajectory points (platform: Nvidia Jetson Orin™Nano with 1024 cores).</p>
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16 pages, 2581 KiB  
Review
Applications, Limitations, and Considerations of Clinical Trials in a Dish
by Amatullah Mir, Angie Zhu, Rico Lau, Nicolás Barr, Zyva Sheikh, Diana Acuna, Anuhya Dayal and Narutoshi Hibino
Bioengineering 2024, 11(11), 1096; https://doi.org/10.3390/bioengineering11111096 - 30 Oct 2024
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Abstract
Recent advancements in biotechnology forged the path for clinical trials in dish (CTiDs) to advance as a popular method of experimentation in biomedicine. CTiDs play a fundamental role in translational research through technologies such as induced pluripotent stem cells, whole genome sequencing, and [...] Read more.
Recent advancements in biotechnology forged the path for clinical trials in dish (CTiDs) to advance as a popular method of experimentation in biomedicine. CTiDs play a fundamental role in translational research through technologies such as induced pluripotent stem cells, whole genome sequencing, and organs-on-a-chip. In this review, we explore advancements that enable these CTiD biotechnologies and their applications in animal testing, disease modeling, and space radiation technologies. Furthermore, this review dissects the advantages and disadvantages of CTiDs, as well as their regulatory considerations. Lastly, we evaluate the challenges that CTiDs pose and the role of CTiDs in future experimentation. Full article
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Graphical abstract

Graphical abstract
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<p>Roadmap overview of “Applications, Limitations, and Considerations for Clinical Trials in Dish” [<a href="#B2-bioengineering-11-01096" class="html-bibr">2</a>].</p>
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<p>Applications of iPSCs in disease modeling, drug development, and cell therapy. Adapted from Sugimoto et al. [<a href="#B2-bioengineering-11-01096" class="html-bibr">2</a>].</p>
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<p>Structure of the organ-on-a-chip device. Adapted from Kurth et al. [<a href="#B7-bioengineering-11-01096" class="html-bibr">7</a>].</p>
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<p>Methods of organoid development in vitro. Cell sources for organoids include embryonic stem cells, adult stem cells, tumor cells, and induced pluripotent stem cells. Adapted from [<a href="#B8-bioengineering-11-01096" class="html-bibr">8</a>].</p>
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<p>Applications of CTiDs (summarized).</p>
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<p>Translation from basic science to human studies. Adapted from Seyhan et al. [<a href="#B1-bioengineering-11-01096" class="html-bibr">1</a>].</p>
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<p>Challenges with CTiD use (summarized).</p>
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