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Keywords = neurobehavioral symptom inventory

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10 pages, 2403 KiB  
Article
The Effect of Bilateral, Two-Level Cervical Sympathetic Chain Blocks on Specific Symptom Clusters for Traumatic Brain Injury, Independent of Concomitant PTSD Symptoms
by Sean W. Mulvaney, James H. Lynch, Sanjay Mahadevan, Kyle J. Dineen and Kristine L. Rae Olmsted
Brain Sci. 2024, 14(12), 1193; https://doi.org/10.3390/brainsci14121193 - 27 Nov 2024
Viewed by 769
Abstract
Background/Objectives: The aim of this study was to determine if performing ultrasound-guided, bilateral, two-level cervical sympathetic chain blocks (2LCSBs) (performed on subsequent days) improves symptoms associated with traumatic brain injury (TBI) that do not overlap with posttraumatic stress disorder (PTSD). Methods: [...] Read more.
Background/Objectives: The aim of this study was to determine if performing ultrasound-guided, bilateral, two-level cervical sympathetic chain blocks (2LCSBs) (performed on subsequent days) improves symptoms associated with traumatic brain injury (TBI) that do not overlap with posttraumatic stress disorder (PTSD). Methods: A retrospective chart review was conducted between August 2022 and February 2023. We identified twenty patients who received bilateral 2LCSBs for PTSD and anxiety symptoms and who also had a history of TBI. Neurobehavioral Symptom Inventory (NSI) scores were collected at baseline, one week, and one month post treatment in 13 males and 7 females. A sub-analysis of the first ten questions of the NSI, which we identified as not overlapping with PTSD or anxiety symptoms, generated an NSI sub-score. Results: Out of 20 patients, all showed improvement in their NSI scores and NSI sub-scores. The NSI sub-scores had a baseline average of 15.45 (on a 40-point scale); the average score at one week post treatment was 8.30; and that at one month post treatment was 7.80. This represents a 49.51% improvement in TBI symptoms which did not overlap with PTSD or anxiety symptoms between baseline and one month. Conclusions: The use of bilateral 2LCSBs may be helpful in treating patients with TBI, regardless of the presence of comorbid PTSD symptoms. Full article
(This article belongs to the Section Neurorehabilitation)
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Figure 1

Figure 1
<p>Decrease in patient NSI scores following 2LCSB intervention at baseline, one week, and one month. Total scores decreased by nearly 50%, while male patients improved by nearly 10% more than female patients.</p>
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<p>Decrease in patient NSI sub-scores for TBI symptoms following 2LCSB intervention at baseline, one week, and one month. Total scores decreased by nearly 50%, while male patients improved by nearly 4% more than female patients.</p>
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<p>Decrease in patient PCL-5 scores for TBI symptoms following 2LCSB intervention at baseline, one week, and one month. Total scores decreased by over 50%, while female patients improved by nearly 7% more than male patients.</p>
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<p>Overlap between TBI and PTSD symptoms as derived from the NSI and PCL-5.</p>
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16 pages, 1178 KiB  
Article
Moderate, Little, or No Improvements in Neurobehavioral Symptoms among Individuals with Long COVID: A 34-Country Retrospective Study
by Daniela Ramos-Usuga, Paul B. Perrin, Yelena Bogdanova, Laiene Olabarrieta-Landa, Elisabet Alzueta, Fiona C. Baker, Stella Iacovides, Mar Cortes and Juan Carlos Arango-Lasprilla
Int. J. Environ. Res. Public Health 2022, 19(19), 12593; https://doi.org/10.3390/ijerph191912593 - 2 Oct 2022
Cited by 5 | Viewed by 3008
Abstract
(1) Background: Some people with COVID-19 develop a series of symptoms that last for several months after infection, known as Long COVID. Although these symptoms interfere with people’s daily functioning and quality of life, few studies have focused on neurobehavioral symptoms and the [...] Read more.
(1) Background: Some people with COVID-19 develop a series of symptoms that last for several months after infection, known as Long COVID. Although these symptoms interfere with people’s daily functioning and quality of life, few studies have focused on neurobehavioral symptoms and the risk factors associated with their development; (2) Methods: 1001 adults from 34 countries who had previously tested positive for COVID-19 completed the Neurobehavioral Symptom Inventory reporting the symptoms before their COVID-19 diagnosis, during the COVID-19 infection, and currently; (3) Results: Participants reported large-sized increases before vs. during COVID-19 in all domains. Participants reported a medium-sized improvement (during COVID-19 vs. now) in somatic symptoms, a small-sized improvement in affective symptoms, and very minor/no improvement in cognitive symptoms. The risk factors for increased neurobehavioral symptoms were: being female/trans, unemployed, younger age, low education, having another chronic health condition, greater COVID-19 severity, greater number of days since the COVID-19 diagnosis, not having received oxygen therapy, and having been hospitalized. Additionally, participants from North America, Europe, and Central Asia reported higher levels of symptoms across all domains relative to Latin America and Sub-Saharan Africa; (4) Conclusions: The results highlight the importance of evaluating and treating neurobehavioral symptoms after COVID-19, especially targeting the higher-risk groups identified. General rehabilitation strategies and evidence-based cognitive rehabilitation are needed in both the acute and Long COVID phases. Full article
(This article belongs to the Special Issue New Advances in Rehabilitation Outcomes Research)
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Figure 1

Figure 1
<p>Covariate-adjusted somatic symptom severity scores (mean with 95% confidence interval) by global region. <bold>Note</bold>: A graphic that shows the differences in somatic symptoms by Global Region. The participants from Europe and Central Asia and North America reported significantly greater somatic symptom severity than participants from Latin America and the Caribbean and Sub-Saharan Africa.</p>
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<p>Covariate-adjusted cognitive symptom severity scores (mean with 95% confidence interval) by global region. <bold>Note</bold>: A graphic that shows the differences in cognitive symptoms by Global Region. The participants from North America reported the greatest cognitive symptoms. Additionally, participants from Europe and Central Asia reported significantly greater cognitive symptom severity than participants from Latin America and the Caribbean and Sub-Saharan Africa.</p>
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<p>Covariate-adjusted affective symptom severity scores (mean with 95% confidence interval) by global region. <bold>Note</bold>: A graphic that shows the differences in affective symptoms by Global Region. The participants from Latin America and the Caribbean reported significantly lower affective symptom severity than participants from Europe and Central Asia, North America, and Sub-Saharan Africa. Participants from Sub-Saharan Africa also reported lower affective symptom severity than those from North America.</p>
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