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Search Results (258)

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Keywords = biomimicry

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19 pages, 8699 KiB  
Article
Parametric Design and Mechanical Characterization of a Selective Laser Sintering Additively Manufactured Biomimetic Ribbed Dome Inspired by the Chorion of Lepidopteran Eggs
by Alexandros Efstathiadis, Ioanna Symeonidou, Emmanouil K. Tzimtzimis, Dimitrios Avtzis, Konstantinos Tsongas and Dimitrios Tzetzis
Biomimetics 2025, 10(1), 1; https://doi.org/10.3390/biomimetics10010001 - 24 Dec 2024
Abstract
The current research aims to analyze the shape and structural features of the eggs of the lepidoptera species Melitaea sp. (Lepidoptera, Nympalidae) and develop design solutions through the implementation of a novel strategy of biomimetic design. Scanning electron microscopy (SEM) analysis of the [...] Read more.
The current research aims to analyze the shape and structural features of the eggs of the lepidoptera species Melitaea sp. (Lepidoptera, Nympalidae) and develop design solutions through the implementation of a novel strategy of biomimetic design. Scanning electron microscopy (SEM) analysis of the chorion reveals a medial zone that forms an arachnoid grid resembling a ribbed dome with convex longitudinal ribs and concave transverse ring members. A parametric design algorithm was created with the aid of computer-aided design (CAD) software Rhinoceros 3D and Grasshopper3D in order to abstract and emulate the biological model. A series of physical models were manufactured with variations in geometric parameters like the number of ribs and rings, their thickness, and curvature. Selective laser sintering (SLS) technology and Polyamide12 (nylon) material were utilized for the prototyping process. Quasi-static compression testing was carried out in conjunction with finite element analysis (FEA) to investigate the deformation patterns and stress dispersion of the models. The biomimetic ribbed dome appears to significantly dampen the snap-through behavior that is observed in typical solid and lattice domes, decreasing dynamic stresses developed during the response and preventing catastrophic failure of the structure. Increasing the curvature of the ring segments further reduces the snap-through phenomenon and improves the overall strength. However, excessive curvature has a negative effect on the maximum sustained load. Increasing the number and thickness of the transverse rings and the number of the longitudinal ribs also increases the strength of the dome. However, excessive increase in the rib radius leads to more acute snap-through behavior and an earlier failure. The above results were validated using respective finite element analyses. Full article
(This article belongs to the Special Issue Biomimetic 3D/4D Printing)
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Figure 1
<p>The novel biomimetic design strategy is characterized by by-directional feedback loops between its three stages: the “Research and Analysis” stage, followed by the “Abstraction and Emulation” stage, and concluded with the “Technical Evaluation” stage.</p>
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<p>Imaging of the eggs of <span class="html-italic">Melitaea</span> sp.: (<b>a</b>) the eggs under optical microscopy as seen deposited on a leaf; (<b>b</b>) a single egg under SEM with its three zones—apical, medial, and basal—visible; (<b>c</b>) close-up of the medial zone where the longitudinal ribs and transversal rings form an arachnoid grip pattern.</p>
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<p>Main geometric characteristics of a dome: (<b>a</b>) longitudinal ribs (n) and transverse rings (a); (<b>b</b>) height (H), its span (D), and the total subtended angle (φ).</p>
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<p>Longitudinal cross-section of a ribbed dome with ring member angle φ/α and rib member angle 2θ<sub>0</sub>.</p>
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<p>The interactive algorithm in the Grasshopper environment.</p>
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<p>Top-level workflow diagram of the design algorithm of the biomimetic ribbed dome. Important parameters are seen in light gray boxes.</p>
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<p>Second-level workflow diagram of the algorithmic generation of the biomimetic dome. Dependent parameters are in white and independent ones in light gray boxes.</p>
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<p>Digital models of the biomimetic dome structure: (<b>a</b>) Model 1 (baseline); (<b>b</b>) Model 2; (<b>c</b>) Model 3; (<b>d</b>) Model 4; (<b>e</b>) Model 5; (<b>f</b>) Model 6; (<b>g</b>) Model 7; (<b>h</b>) Model 8; (<b>i</b>) Model 9; (<b>j</b>) Model 10; (<b>k</b>) Model 11.</p>
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<p>Three-dimensionally printed specimens of the biomimetic dome structure: (<b>a</b>) Model 1 (baseline); (<b>b</b>) Model 2; (<b>c</b>) Model 3; (<b>d</b>) Model 4; (<b>e</b>) Model 5; (<b>f</b>) Model 6; (<b>g</b>) Model 7; (<b>h</b>) Model 8; (<b>i</b>) Model 9; (<b>j</b>) Model 10; (<b>k</b>) Model 11.</p>
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<p>Compressive behavior at 0 mm, 1.25 mm, 2.5 mm, and 5 mm of (<b>a</b>) Model 1 (baseline); (<b>b</b>) Model 2; (<b>c</b>) Model 3; (<b>d</b>) Model 4; (<b>e</b>) Model 5; (<b>f</b>) Model 6; (<b>g</b>) Model 7; (<b>h</b>) Model 8; (<b>i</b>) Model 9; (<b>j</b>) Model 10 and (<b>k</b>) Model 11.</p>
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<p>Failure points of the ribbed dome: (<b>a</b>) buckling and fracture of individual rib members; (<b>b</b>) buckling and fracture of individual ring members; (<b>c</b>) line instability, where a whole ring collapses.</p>
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<p>A typical curve of the snap-through response is observed in a solid or regular ribbed dome under compressive load.</p>
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<p>Load–deflection curves of the 3D-printed biomimetic domes when tested under compressive load.</p>
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<p>(<b>a</b>) The stress–strain behavior of the biomimetic lattice structures generated by finite element analysis (FEA), (<b>b</b>) vertical deformation, and (<b>c</b>) stress distribution of the biomimetic structure under compression load were analyzed using the material properties of PA12 within the FE model.</p>
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<p>(<b>a</b>) The stress–strain behavior of the biomimetic lattice structures generated by finite element analysis (FEA), (<b>b</b>) vertical deformation, and (<b>c</b>) stress distribution of the biomimetic structure under compression load were analyzed using the material properties of PA12 within the FE model.</p>
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20 pages, 3395 KiB  
Article
Innovative Ink-Based 3D Hydrogel Bioprinted Formulations for Tissue Engineering Applications
by Ana Catarina Sousa, Grace Mcdermott, Fraser Shields, Rui Alvites, Bruna Lopes, Patrícia Sousa, Alícia Moreira, André Coelho, José Domingos Santos, Luís Atayde, Nuno Alves, Stephen M. Richardson, Marco Domingos and Ana Colette Maurício
Gels 2024, 10(12), 831; https://doi.org/10.3390/gels10120831 - 17 Dec 2024
Viewed by 438
Abstract
Three-dimensional (3D) models with improved biomimicry are essential to reduce animal experimentation and drive innovation in tissue engineering. In this study, we investigate the use of alginate-based materials as polymeric inks for 3D bioprinting of osteogenic models using human bone marrow stem/stromal cells [...] Read more.
Three-dimensional (3D) models with improved biomimicry are essential to reduce animal experimentation and drive innovation in tissue engineering. In this study, we investigate the use of alginate-based materials as polymeric inks for 3D bioprinting of osteogenic models using human bone marrow stem/stromal cells (hBMSCs). A composite bioink incorporating alginate, nano-hydroxyapatite (nHA), type I collagen (Col) and hBMSCs was developed and for extrusion-based printing. Rheological tests performed on crosslinked hydrogels confirm the formation of solid-like structures, consistently indicating a superior storage modulus in relation to the loss modulus. The swelling behavior analysis showed that the addition of Col and nHA into an alginate matrix can enhance the swelling rate of the resulting composite hydrogels, which maximizes cell proliferation within the structure. The LIVE/DEAD assay outcomes demonstrate that the inclusion of nHA and Col did not detrimentally affect the viability of hBMSCs over seven days post-printing. PrestoBlueTM revealed a higher hBMSCs viability in the alginate-nHA-Col hydrogel compared to the remaining groups. Gene expression analysis revealed that alginate-nHA-col bioink favored a higher expression of osteogenic markers, including secreted phosphoprotein-1 (SPP1) and collagen type 1 alpha 2 chain (COL1A2) in hBMSCs after 14 days, indicating the pro-osteogenic differentiation potential of the hydrogel. This study demonstrates that the incorporation of nHA and Col into alginate enhances osteogenic potential and therefore provides a bioprinted model to systematically study osteogenesis and the early stages of tissue maturation in vitro. Full article
(This article belongs to the Special Issue Recent Research on Alginate Hydrogels in Bioengineering Applications)
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<p>Rheological experiments with the storage moduli (G′) (shown in black) and loss moduli (G″) (shown in red) of crosslinked alginate and alginate-nHA-Col under a range of conditions. (<b>a</b>) Amplitude sweeps performed at a frequency of 1 Hz. (<b>b</b>) Frequency sweeps performed at an oscillation strain of 0.1%. The evaluations were performed in triplicate.</p>
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<p>Stress–strain curves resulting from compression tests of alginate hydrogel (red) and alginate-nHA-Col hydrogel (black) (<span class="html-italic">n</span> = 3).</p>
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<p>Hydrogel swelling rate from 1 to 72 h. Alg: alginate (red); Alg-nHA-Col (black) (<span class="html-italic">n</span> = 3).</p>
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<p>(<b>A</b>) CAD model designed in BioCAM™ software (version 2.0); (<b>B</b>) 3D generated model; (<b>C</b>) 3D generated model in a 12-well plate; (<b>D</b>) Cell-laden print in the agarose support bath.</p>
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<p>(<b>A</b>) Live/dead staining images of printed hBMSCs in alginate and alginate-nHA-Col after 1, 3, and 7 days in culture. Live cells are stained green and dead cells are stained red. (<b>B</b>) The percentage of cell viability of bioprinted hBMSCs cultured in 2% alginate and 2% alginate-0.5% nHA-0.5% Col for 1, 3, and 7 days (<span class="html-italic">n</span> = 3).</p>
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<p>(<b>A</b>) Corrected absorbance evaluated by Presto Blue<sup>®</sup> viability assay for hBMSCs (<span class="html-italic">n</span> = 3). Result significances are presented through the symbol (*), according to the <span class="html-italic">p</span> value, with * <span class="html-italic">p</span> &lt; 0.05. (<b>B</b>) Percent viability inhibition assay. The results were normalized in relation to the control. The 30% threshold shown (dashed line) represents the inhibition above which the effect is considered cytotoxic (under ISO 10993-5:2009 guidelines).</p>
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<p>Gene expression levels of printed hBMSCs in alginate and alginate-nHA-Col bioinks after 7 and 14 days under osteogenic differentiation: runt-related transcription factor 2 (RUNX2) (<b>A</b>), alkaline phosphatase (ALPL) (<b>B</b>), integrin-binding sialoprotein (IBSP) (<b>C</b>), secreted phosphoprotein-1 (SPP1) (<b>D</b>), and collagen type 1 alpha 2 chain (COL1A2) (<b>E</b>).</p>
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<p>Graphical representation of the preparation of alginate and alginate-nHA-Col-based solutions.</p>
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<p>(<b>A</b>) 3D Discovery Evolution bioprinter; (<b>B</b>) Schematic representation of the pressure-assisted extrusion process, in which pressurized air drives the bioink from the bioprinter cartridge through a needle into a well plate containing a suspension bath.</p>
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38 pages, 938 KiB  
Review
Eco Breakthroughs: Sustainable Materials Transforming the Future of Our Planet
by Catalin Popescu, Hiranya Dissanayake, Egla Mansi and Adrian Stancu
Sustainability 2024, 16(23), 10790; https://doi.org/10.3390/su162310790 - 9 Dec 2024
Viewed by 1127
Abstract
Interest in the sustainable materials sector is growing and accelerated. These materials are designed to reduce the use of non-renewable resources, limit greenhouse gas emissions, and be recyclable or biodegradable, making them highly attractive to both academia and industry. Constantly updating on innovations [...] Read more.
Interest in the sustainable materials sector is growing and accelerated. These materials are designed to reduce the use of non-renewable resources, limit greenhouse gas emissions, and be recyclable or biodegradable, making them highly attractive to both academia and industry. Constantly updating on innovations in this field is essential to speed up the transition to a circular economy and significantly reduce environmental impact. The paper analyzes the current status and future trends of the scientific literature for seven sustainability-related materials categories, such as sustainable materials, green materials, biomaterials, eco-friendly materials, alternative materials, material recycling and material recovery from complex products, and sustainable applied materials. Next, it assesses the impacts, benefits, and challenges associated with sustainable materials from the scientific literature according to six research fields (impact on the environment, performance and durability, economic efficiency, health and safety, social sustainability, and implementation and use). Furthermore, the paper outlines recent advances in sustainable material design, including biomimicry, nanotechnology, additive manufacturing, 3D printing, and sustainable composite materials. Additionally, a bibliometric analysis of 545 studies on sustainable materials published between 1999 and 2023 was conducted based on eight criteria, namely trend, source, author, country, keywords, thematic, co-citation, and content. The findings show that the sustainability-related materials categories have a particular distribution among the domains. Also, the thematic map analysis outlines that biopolymers, nanocellulose, and biocomposites are critical research areas for developing sustainable materials. Full article
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<p>Thematic map.</p>
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<p>Thematic evolution.</p>
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23 pages, 3727 KiB  
Review
Three-Dimensional Bioprinting for Retinal Tissue Engineering
by Kevin Y. Wu, Rahma Osman, Natalie Kearn and Ananda Kalevar
Biomimetics 2024, 9(12), 733; https://doi.org/10.3390/biomimetics9120733 - 1 Dec 2024
Viewed by 836
Abstract
Three-dimensional bioprinting (3DP) is transforming the field of regenerative medicine by enabling the precise fabrication of complex tissues, including the retina, a highly specialized and anatomically complex tissue. This review provides an overview of 3DP’s principles, its multi-step process, and various bioprinting techniques, [...] Read more.
Three-dimensional bioprinting (3DP) is transforming the field of regenerative medicine by enabling the precise fabrication of complex tissues, including the retina, a highly specialized and anatomically complex tissue. This review provides an overview of 3DP’s principles, its multi-step process, and various bioprinting techniques, such as extrusion-, droplet-, and laser-based methods. Within the scope of biomimicry and biomimetics, emphasis is placed on how 3DP potentially enables the recreation of the retina’s natural cellular environment, structural complexity, and biomechanical properties. Focusing on retinal tissue engineering, we discuss the unique challenges posed by the retina’s layered structure, vascularization needs, and the complex interplay between its numerous cell types. Emphasis is placed on recent advancements in bioink formulations, designed to emulate retinal characteristics and improve cell viability, printability, and mechanical stability. In-depth analyses of bioinks, scaffold materials, and emerging technologies, such as microfluidics and organ-on-a-chip, highlight the potential of bioprinted models to replicate retinal disease states, facilitating drug development and testing. While challenges remain in achieving clinical translation—particularly in immune compatibility and long-term integration—continued innovations in bioinks and scaffolding are paving the way toward functional retinal constructs. We conclude with insights into future research directions, aiming to refine 3DP for personalized therapies and transformative applications in vision restoration. Full article
(This article belongs to the Special Issue Biomimetic 3D/4D Printing)
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<p>Three-dimensional bioprinting process and types of bioprinting. Created in BioRender.</p>
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<p>Keeling et al. [<a href="#B26-biomimetics-09-00733" class="html-bibr">26</a>] created reconstructed images of mice RPE 3D architecture (lateral view) showing apical microvilli (green) and nuclei (blue) with transparent cytoplasm allowing visualization of the convoluted basolateral Bruch’s membrane (yellow) with sub-RPE spaces (purple) and photoreceptors (light blue). Created in BioRender.</p>
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<p>Deep to the outer pigmented aspect of the retina is the nine layers within the inner neural layer of the retina. The retina is located between the vitreous body and choroid [<a href="#B27-biomimetics-09-00733" class="html-bibr">27</a>]. Copyright certificate is CC by 3.0 license.</p>
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<p>Retina structures cartoonized. Note: not all retinal layers are depicted in this figure. Created in BioRender.</p>
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<p>Diagrammatic representation of the major requirements for a successful bioink. Created in BioRender.</p>
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<p>Cartoonized rendering of the decellularization process for the development of decellularized ECM (dECM) biomaterial. The progressive loss of colour in this figure represents the loss of intracellular components in the decellularization process. The native retina tissue for which the ECM is derived is rendered in red, emblematic of the complex protein structures and intracellular environment supporting the native ECM. The final dECM product is rendered in gray, stripped of the native supportive proteins and growth-promoting intracellular environment. Created in BioRender.</p>
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<p>Flow chart summarizing recent advancements of scaffold engineering in 3D retinal bioprinting. Many scaffolds are made with gellan gum (GG) as a base for its improved strength during the printing process. Created in Biorender.</p>
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<p>Schematic representation of the oBRB. CC = choriocapillaris; TJ = tight junction. Created in Biorender.</p>
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<p>Graphical representation of the drug-loaded combined bevacizumab/dexamethasone rod invention [<a href="#B94-biomimetics-09-00733" class="html-bibr">94</a>]. Created in Biorender.</p>
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17 pages, 10421 KiB  
Article
Design and Simulation Study of Structural Parameters of Bionic Cutters for Tea Harvest Imitating Aeolesthes induta Newman
by Yuanqiang Luo, Junlin Li, Song He and Weibin Wu
Appl. Sci. 2024, 14(21), 9763; https://doi.org/10.3390/app14219763 - 25 Oct 2024
Viewed by 573
Abstract
The cutter of the hand-held tea picker is the key cutting component in the efficient tea harvesting process. In order to solve the problems of large cutting resistance and uneven incision during tea picking, this study fully applied the bionics principle to combine [...] Read more.
The cutter of the hand-held tea picker is the key cutting component in the efficient tea harvesting process. In order to solve the problems of large cutting resistance and uneven incision during tea picking, this study fully applied the bionics principle to combine the excellent cutting performance of Aeolesthes induta Newman’s mandibles with the tea cutter, which extracted and fitted the tooth profile structure curve of the upper edge of the Aeolesthes induta Newman’s mandibles. The trapezoidal teeth on the reciprocating cutter of ordinary hand-held tea-picking harvesters were optimized by the fitted curve, and a new tea cutter with the shape of Aeolesthes induta Newman teeth was obtained, which included four kinds of bionic tea-harvesting cutters. The multi-body system software ADAMS 2020 and finite element analysis software ANSYS 2024R1 were used to compare the kinematics, statics and explicit dynamics of cutting properties of the four bionic cutters and common cutters with ordinary trapezoidal teeth and saw teeth. The simulation results showed that the maximum equivalent elastic strain and the maximum cutting force during the cutting operation were reduced by 36.7% and 42.89%, respectively, for the cutting teeth of the bionic tea-harvesting cutter #4 compared with that of the cutter with ordinary trapezoidal teeth. The bionic tea-harvesting cutter designed in this study has better cutting performance than the cutter with traditional cutting teeth, which can effectively reduce the cutting force and improve the flatness and cutting quality of the cutting surface. Full article
(This article belongs to the Section Agricultural Science and Technology)
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<p><span class="html-italic">Aeolesthes induta</span> Newman. (<b>A</b>) Sample; (<b>B</b>) The upper part of the mouth; (<b>C</b>) Single-curved tooth structure.</p>
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<p><span class="html-italic">Aeolesthes induta</span> Newman and its mouthpiece structure.</p>
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<p>Extracted contour line of the teeth of the <span class="html-italic">Aeolesthes induta</span> Newman.</p>
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<p>Fitted curve of upper jaw and its residual value. (<b>A</b>) Fitted curve; (<b>B</b>) Residuals; (<b>C</b>) Second derivative; (<b>D</b>) Curvature.</p>
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<p>Three-dimensional model of four cutter schemes. (<b>A</b>) Bionic tea-harvesting cutter #1; (<b>B</b>) Bionic tea-harvesting cutter #2; (<b>C</b>) Bionic tea-harvesting cutter #3; (<b>D</b>) Bionic tea-harvesting cutter #4.</p>
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<p>The cutting teeth of the four schemes cut the tea stalk (the gray circle represents the tea stalk, and the gray arrow represents the movement direction of the bionic cutting teeth). (<b>A</b>) Cutting collocation mode I of bionic cutting teeth 1; (<b>B</b>) Cutting collocation mode II of bionic cutting teeth 1; (<b>C</b>) Cutting collocation mode III of bionic cutting teeth 1; (<b>D</b>) Cutting collocation mode of bionic cutting teeth 2; (<b>E</b>) Cutting collocation mode of bionic cutting teeth 3.</p>
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<p>Motion cutting trajectory diagram of bionic tea-harvesting cutters. (<b>A</b>) Bionic tea-harvesting cutter #1; (<b>B</b>) Bionic tea-harvesting cutter #2; (<b>C</b>) Bionic tea-harvesting cutter #3.</p>
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<p>Static structural constraint load settings for bionic cutting teeth 3 and 4.</p>
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<p>Static simulation test of cutting teeth. (<b>A</b>) Ordinary trapezoidal tooth. (<b>B</b>) Ordinary saw tooth. (<b>C</b>) Bionic cutting tooth 1. (<b>D</b>) Bionic cutting tooth 2. (<b>E</b>) Bionic cutting tooth 3.</p>
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<p>Explicit dynamics constraint load settings for bionic cutting teeth 3 and 4.</p>
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<p>The cutting tea stalk process of bionic cutting teeth 3. (<b>A</b>) Before the cut, (<b>B</b>) Cutting starts, (<b>C</b>) Halfway cut and (<b>D</b>) Total cut.</p>
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<p>Explicit dynamic simulation test of 7 cutting collocation modes with 5 cutting teeth. (<b>A</b>) Cutting collocation mode of ordinary trapezoidal teeth; (<b>B</b>) Cutting collocation mode I of bionic cutting teeth l; (<b>C</b>) Cutting collocation mode II of bionic cutting teeth l; (<b>D</b>) Cutting collocation mode III of bionic cutting teeth l; (<b>E</b>) Cutting collocation mode of bionic cutting teeth 2; (<b>F</b>) Cutting collocation mode of ordinary saw teeth; (<b>G</b>) Cutting collocation mode of cutting teeth 3.</p>
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19 pages, 9872 KiB  
Article
A Portable Electronic Nose Coupled with Deep Learning for Enhanced Detection and Differentiation of Local Thai Craft Spirits
by Supakorn Harnsoongnoen, Nantawat Babpan, Saksun Srisai, Pongsathorn Kongkeaw and Natthaphon Srisongkram
Chemosensors 2024, 12(10), 221; https://doi.org/10.3390/chemosensors12100221 - 19 Oct 2024
Viewed by 1196
Abstract
In this study, our primary focus is the biomimetic design and rigorous evaluation of an economically viable and portable ‘e-nose’ system, tailored for the precise detection of a broad range of volatile organic compounds (VOCs) in local Thai craft spirits. This e-nose system [...] Read more.
In this study, our primary focus is the biomimetic design and rigorous evaluation of an economically viable and portable ‘e-nose’ system, tailored for the precise detection of a broad range of volatile organic compounds (VOCs) in local Thai craft spirits. This e-nose system is innovatively equipped with cost-efficient metal oxide gas sensors and a temperature/humidity sensor, ensuring comprehensive and accurate sensing. A custom-designed real-time data acquisition system is integrated, featuring gas flow control, humidity filters, dual sensing/reference chambers, an analog-to-digital converter, and seamless data integration with a laptop. Deep learning, utilizing a multilayer perceptron (MLP), is employed to achieve highly effective classification of local Thai craft spirits, demonstrated by a perfect classification accuracy of 100% in experimental studies. This work underscores the significant potential of biomimetic principles in advancing cost-effective, portable, and analytically precise e-nose systems, offering valuable insights into future applications of advanced gas sensor technology in food, biomedical, and environmental monitoring and safety. Full article
(This article belongs to the Special Issue Gas Sensors and Electronic Noses for the Real Condition Sensing)
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<p>E-nose system.</p>
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<p>E-nose configuration: (<b>a</b>) gas flow direction and (<b>b</b>) sensor interface.</p>
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<p>A low-cost portable electronic nose: (<b>a</b>) top and front view and (<b>b</b>) inside view.</p>
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<p>Measurement setup.</p>
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<p>Data extraction: (<b>a</b>) sensor response and (<b>b</b>) data extraction.</p>
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<p>Multilayer perceptron architecture.</p>
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<p>Temperature and humidity sensing: (<b>a</b>) temperature and (<b>b</b>) humidity.</p>
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<p>Relationship of humidity to various quantities: (<b>a</b>) time, (<b>b</b>) MQ-135, (<b>c</b>) MQ-136, (<b>d</b>) MQ-137, (<b>e</b>) MQ-138, (<b>f</b>) MQ-139, (<b>g</b>) MQ-9, (<b>h</b>) MQ-6, and (<b>i</b>) MQ-3.</p>
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<p>Relationship of humidity to various quantities: (<b>a</b>) time, (<b>b</b>) MQ-135, (<b>c</b>) MQ-136, (<b>d</b>) MQ-137, (<b>e</b>) MQ-138, (<b>f</b>) MQ-139, (<b>g</b>) MQ-9, (<b>h</b>) MQ-6, and (<b>i</b>) MQ-3.</p>
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<p>Gas sensor response: (<b>a</b>) Koon, (<b>b</b>) Onson, (<b>c</b>) Pandanus, and (<b>d</b>) alcohol.</p>
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<p>Maximum and minimum of sensor response: (<b>a</b>) Koon, (<b>b</b>) Onson, (<b>c</b>) Pandanus, and (<b>d</b>) alcohol.</p>
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<p>Pair plot of sensor responses based on local Thai craft spirits.</p>
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<p>Heatmap of correlation coefficients between gas sensors based on local Thai craft spirits.</p>
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<p>The decision regions in 2D derived from the 8 input features of the sensor array: (<b>a</b>) MLP with PCA and (<b>b</b>) K-means with PCA.</p>
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<p>Scatter plots and classifications: (<b>a</b>) and (<b>b</b>) MQ-136 vs. MQ-3, (<b>c</b>) and (<b>d</b>) MQ-136 vs. MQ-6, (<b>e</b>) and (<b>f</b>) MQ-136 vs. MQ-9, (<b>g</b>) and (<b>h</b>) MQ-136 vs. MQ-135, (<b>i</b>) and (<b>j</b>) MQ-136 vs. MQ-137, (<b>k</b>) and (<b>l</b>) MQ-136 vs. MQ-138, and (<b>m</b>) and (<b>n</b>) MQ-136 vs. MQ-139.</p>
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<p>Scatter plots and classifications: (<b>a</b>) and (<b>b</b>) MQ-136 vs. MQ-3, (<b>c</b>) and (<b>d</b>) MQ-136 vs. MQ-6, (<b>e</b>) and (<b>f</b>) MQ-136 vs. MQ-9, (<b>g</b>) and (<b>h</b>) MQ-136 vs. MQ-135, (<b>i</b>) and (<b>j</b>) MQ-136 vs. MQ-137, (<b>k</b>) and (<b>l</b>) MQ-136 vs. MQ-138, and (<b>m</b>) and (<b>n</b>) MQ-136 vs. MQ-139.</p>
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<p>Classifications: (<b>a</b>) MQ-136 vs. MQ-3, (<b>b</b>) MQ-136 vs. MQ-6, (<b>c</b>) MQ-136 vs. MQ-9, (<b>d</b>) MQ-136 vs. MQ-135, (<b>e</b>) MQ-136 vs. MQ-137, (<b>f</b>) MQ-136 vs. MQ-138, and (<b>g</b>) MQ-136 vs. MQ-139.</p>
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15 pages, 3082 KiB  
Article
Diseased Tendon Models Demonstrate Influence of Extracellular Matrix Alterations on Extracellular Vesicle Profile
by Kariman A. Shama, Zachary Franklin Greenberg, Chadine Tammame, Mei He and Brittany L. Taylor
Bioengineering 2024, 11(10), 1019; https://doi.org/10.3390/bioengineering11101019 - 12 Oct 2024
Viewed by 1177
Abstract
Tendons enable movement through their highly aligned extracellular matrix (ECM), predominantly composed of collagen I. Tendinopathies disrupt the structural integrity of tendons by causing fragmentation of collagen fibers, disorganization of fiber bundles, and an increase in glycosaminoglycans and microvasculature, thereby driving the apparent [...] Read more.
Tendons enable movement through their highly aligned extracellular matrix (ECM), predominantly composed of collagen I. Tendinopathies disrupt the structural integrity of tendons by causing fragmentation of collagen fibers, disorganization of fiber bundles, and an increase in glycosaminoglycans and microvasculature, thereby driving the apparent biomechanical and regenerative capacity in patients. Moreover, the complex cellular communication within the tendon microenvironment ultimately dictates the fate between healthy and diseased tendon, wherein extracellular vesicles (EVs) may facilitate the tendon’s fate by transporting biomolecules within the tissue. In this study, we aimed to elucidate how the EV functionality is altered in the context of tendon microenvironments by using polycaprolactone (PCL) electrospun scaffolds mimicking healthy and pathological tendon matrices. Scaffolds were characterized for fiber alignment, mechanical properties, and cellular activity. EVs were isolated and analyzed for concentration, heterogeneity, and protein content. Our results show that our mimicked healthy tendon led to an increase in EV secretion and baseline metabolic activity over the mimicked diseased tendon, where reduced EV secretion and a significant increase in metabolic activity over 5 days were observed. These findings suggest that scaffold mechanics may influence EV functionality, offering insights into tendon homeostasis. Future research should further investigate how EV cargo affects the tendon’s microenvironment. Full article
(This article belongs to the Special Issue Biomaterial Scaffolds for Tissue Engineering)
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Figure 1

Figure 1
<p>(<b>A</b>) SEM micrographs taken at 3000X magnification display the fibril morphology and configuration. (<b>B</b>) Fibril configuration was measured using ImageJ plugin, OrientationJ (<span class="html-italic">N</span> = 3 scaffolds per group). (<b>C</b>) The sum of fibers for each scaffold group within one degree from the neutral axis was measured and then plotted to demonstrate fibril orientation (<span class="html-italic">N</span> = 3 scaffolds per group). Mechanical testing employing a ramp-to-failure protocol with a strain rate of 0.3% per second was used to measure (<b>D</b>) Young’s modulus and (<span class="html-italic">N</span> = 6) (<b>E</b>) ultimate tensile strength (<span class="html-italic">N</span> = 6). (<b>F</b>) Fibril diameter was measured (<span class="html-italic">N</span> = 3 scaffolds) utilizing ImageJ. Mechanical and fibril diameter data are results of a one-way ANOVA with Tukey’s HSD post hoc test. Significance was defined as <span class="html-italic">p</span> &lt; 0.05 (*), ** <span class="html-italic">p</span> &lt; 0.01, **** <span class="html-italic">p</span> &lt; 0.0001. Data are expressed as mean ± standard deviation. The gray range in panels (<b>D</b>–<b>F</b>) indicates range of Young’s Moduli (50–170 MPa), UTS (4.1–16.5 MPa) and fibril diameter (1–20 µm) for healthy human supraspinatus tendon [<a href="#B3-bioengineering-11-01019" class="html-bibr">3</a>,<a href="#B39-bioengineering-11-01019" class="html-bibr">39</a>].</p>
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<p>(<b>A</b>) TEM micrograph taken at 120 kX magnification displays spherical morphology of the EVs. (<b>B</b>) Western blot demonstrates expression of TSG101, CD63, and CD81 in all scaffold groups at all three timepoints. (<b>C</b>) Analysis of the Western blot bands indicate no significant variations in EV marker expressions. (<b>D</b>) BCA analysis quantifies the protein content in the EV samples, revealing significant variation between the 50% <span class="html-italic">w</span>/<span class="html-italic">v</span> and 75% <span class="html-italic">w</span>/<span class="html-italic">v</span> concentrations spun at 100 RPM on day 1. (<b>E</b>) BCA analysis demonstrates an overall consistency in EV protein content amongst the groups apart from the 50% <span class="html-italic">w</span>/<span class="html-italic">v</span> 100 RPM and 75% <span class="html-italic">w</span>/<span class="html-italic">v</span> 100 RPM groups on Day 1. (<b>F</b>) Particle size distribution of EVs amongst the scaffold groups. All data are results of a two-way ANOVA with Tukey’s HSD post hoc test. Significance was defined as <span class="html-italic">p</span> &lt; 0.05 (*). Data are expressed as mean ± standard deviation.</p>
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<p>(<b>A</b>) Nuclear staining conducted to observe cell adhesion to nanofibrous scaffolds relative to TCP monolayer control at all timepoints. Fluorescence images were taken at 10X magnification. (<b>B</b>) Quantitative analysis of cellular proliferation demonstrates significantly greater number of cells in all nanofibrous scaffolds relative to TCP monolayer controls at Day 3. Day 5 demonstrates a similar trend except for the 50% <span class="html-italic">w</span>/<span class="html-italic">v</span> 100 RPM scaffold group (<span class="html-italic">N</span> = 3). (<b>C</b>) Metabolic activity of the cells was measured over the 5-day study, with the nanofibrous scaffolds having significantly reduced metabolic activity relative to the TCP monolayer control on Days 3 and 5 (<span class="html-italic">N</span> = 3). (<b>D</b>) Analysis of metabolic activity per cell demonstrates no significant variations between the nanofibrous scaffolds and the TCP monolayer control (<span class="html-italic">N</span> = 3). All data are results of a two-way ANOVA with Tukey’s HSD post hoc test. Significance was defined as <span class="html-italic">p</span> &lt;  0.05 (*), ** <span class="html-italic">p</span> &lt; 0.01, *** <span class="html-italic">p</span> &lt; 0.001, **** <span class="html-italic">p</span> &lt; 0.0001. Data are expressed as mean ± standard deviation.</p>
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<p>(<b>A</b>) Nanoparticle tracking analysis (NTA) revealed significantly greater extracellular vesicle (EV) secretion in all nanofibrous scaffolds compared to the tissue culture plastic (TCP) control on Day 1. This trend continued on Day 5, particularly in the 75% <span class="html-italic">w</span>/<span class="html-italic">v</span> 100 RPM group. Additionally, significant differences in EV secretion were observed on Day 5 between the 75% <span class="html-italic">w</span>/<span class="html-italic">v</span> and 50% <span class="html-italic">w</span>/<span class="html-italic">v</span> groups, both spun at 100 RPM. (<b>B</b>) A time-dependent increase in EV secretion was observed in the monolayer group between Days 1 and 3, and in the 75% <span class="html-italic">w</span>/<span class="html-italic">v</span> nanofibrous scaffolds between Days 1 and 5. (<b>C</b>) On Day 1, there was a significant increase in EV yield per cell in all groups compared to the monolayer control, except for the 50% <span class="html-italic">w</span>/<span class="html-italic">v</span> 100 RPM group. By Day 5, the 75% <span class="html-italic">w</span>/<span class="html-italic">v</span> group exhibited a significantly higher EV yield per cell compared to the 50% <span class="html-italic">w</span>/<span class="html-italic">v</span> 100 RPM group. (<b>D</b>) EV purity was assessed, with significant variations observed only on Day 1 between the 50% <span class="html-italic">w</span>/<span class="html-italic">v</span> 100 RPM group and the monolayer control. All data are results of a two-way ANOVA with Tukey’s HSD post hoc test. Significance was defined as <span class="html-italic">p</span> &lt;  0.05 (*), ** <span class="html-italic">p</span> &lt; 0.01, *** <span class="html-italic">p</span> &lt; 0.001, **** <span class="html-italic">p</span> &lt; 0.0001. Data are expressed as mean ± standard deviation.</p>
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5 pages, 169 KiB  
Editorial
Editorial Board Members’ Collection Series: Biomimetic Design, Constructions and Devices in Times of Change I
by Ille C. Gebeshuber
Biomimetics 2024, 9(10), 614; https://doi.org/10.3390/biomimetics9100614 - 10 Oct 2024
Viewed by 846
Abstract
In light of recent global crises, including climate change, species extinction, the COVID-19 pandemic, social upheavals and energy supply challenges, this Special Issue of Biomimetics, entitled “Editorial Board Members’ Collection Series: Biomimetic Design, Constructions and Devices in Times of Change”, aims to [...] Read more.
In light of recent global crises, including climate change, species extinction, the COVID-19 pandemic, social upheavals and energy supply challenges, this Special Issue of Biomimetics, entitled “Editorial Board Members’ Collection Series: Biomimetic Design, Constructions and Devices in Times of Change”, aims to explore innovative solutions through biomimetics. This collection features research on various biomimetic applications, such as the peptide-based detection of SARS-CoV-2 antibodies, ergonomic improvements for prolonged sitting, biomimicry industry trends, prosthetic foot functionality and agricultural machinery efficiency. The methods employed include peptide synthesis for diagnostics, simulation software for ergonomic designs, patent analysis for biomimicry trends and engineering discrete element methods for agricultural applications. The findings highlight significant advancements in health diagnostics, ergonomic safety, technological development, prosthetics and sustainable agriculture. The research underscores the potential of biomimetic approaches to address contemporary challenges by leveraging nature-inspired designs and processes. These insights contribute to a broader understanding of how biomimetic principles can lead to adaptive and sustainable solutions in times of change, promoting resilience and innovation across various fields. Full article
54 pages, 14244 KiB  
Review
Manufacturing, Processing, and Characterization of Self-Expanding Metallic Stents: A Comprehensive Review
by Saeedeh Vanaei, Mahdi Hashemi, Atefeh Solouk, Mohsen Asghari Ilani, Omid Amili, Mohamed Samir Hefzy, Yuan Tang and Mohammad Elahinia
Bioengineering 2024, 11(10), 983; https://doi.org/10.3390/bioengineering11100983 - 29 Sep 2024
Viewed by 1930
Abstract
This paper aims to review the State of the Art in metal self-expanding stents made from nitinol (NiTi), showing shape memory and superelastic behaviors, to identify the challenges and the opportunities for improving patient outcomes. A significant contribution of this paper is its [...] Read more.
This paper aims to review the State of the Art in metal self-expanding stents made from nitinol (NiTi), showing shape memory and superelastic behaviors, to identify the challenges and the opportunities for improving patient outcomes. A significant contribution of this paper is its extensive coverage of multidisciplinary aspects, including design, simulation, materials development, manufacturing, bio/hemocompatibility, biomechanics, biomimicry, patency, and testing methodologies. Additionally, the paper offers in-depth insights into the latest practices and emerging trends, with a special emphasis on the transformative potential of additive manufacturing techniques in the development of metal stents. By consolidating existing knowledge and highlighting areas for future innovation, this review provides a valuable roadmap for advancing nitinol stents. Full article
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Graphical abstract

Graphical abstract
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<p>A timeline for the development of the stents from early 1960s. The evolution from the first to the second generation is depicted.</p>
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<p>(<b>a</b>) Mg alloy stent. Reproduced from open access journals [<a href="#B40-bioengineering-11-00983" class="html-bibr">40</a>] (<b>b-I</b>) braided NiTi stent, (<b>b-II</b>) laser cut NiTi stent. Reprinted with permission [<a href="#B41-bioengineering-11-00983" class="html-bibr">41</a>]. Copyright 2021, Elsevier. (<b>c</b>) Cobalt alloy (<b>d</b>) Tantalum alloy stent. Reprinted with permission ([<a href="#B42-bioengineering-11-00983" class="html-bibr">42</a>]). Copyright 2009, Taylor &amp; Francis.</p>
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<p>Classifications of metallic stents based on different terms.</p>
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<p>Classifications of coatings used for metal stents.</p>
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<p>Schematic illustration of hot extrusion and cold tube drawing processes.</p>
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<p>A schematic illustration of the electroforming method for manufacturing pure iron stent. Reproduced with permission [<a href="#B30-bioengineering-11-00983" class="html-bibr">30</a>]. Copyright 2022, Elsevier.</p>
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<p>Schematic illustrations of textile construction methods for manufacturing metal stents: (<b>a</b>) braiding and (<b>b</b>) knitting. Reproduced with permission [<a href="#B30-bioengineering-11-00983" class="html-bibr">30</a>]. copyright 2019, Elsevier.</p>
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<p>Manufacturing methods of SEMSs.</p>
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<p>Designs of stents: (<b>a</b>) slotted tube, (<b>b</b>) coiled stent, (<b>c</b>) braided stent, (<b>d</b>) knitted stent, and (<b>e</b>) helical. Reproduced with permission [<a href="#B30-bioengineering-11-00983" class="html-bibr">30</a>]. Copyright 2022, Elsevier. (<b>f</b>) covered, (<b>g</b>) uncovered stents. Reproduced with permission [<a href="#B95-bioengineering-11-00983" class="html-bibr">95</a>]. Copyright 2010, Elsevier.</p>
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<p>Surface characteristics of NiTi stents: bare NiTi stent struts at (<b>a-I</b>) low and (<b>a-II</b>) high magnification. Reprinted from open access journals [<a href="#B106-bioengineering-11-00983" class="html-bibr">106</a>]. (<b>b</b>) stent manufactured by LPBF. Reprinted from open access journals [<a href="#B107-bioengineering-11-00983" class="html-bibr">107</a>], (<b>c</b>) surface after mechanical polish, (<b>d</b>) after passivation, and (<b>e</b>) after electropolishing [<a href="#B108-bioengineering-11-00983" class="html-bibr">108</a>]. Copyright 2006, Elsevier.</p>
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<p>Different surface characteristics of stents. This illustration shows that biocompatibility and corrosion resistance are affected by the post-surface treatments.</p>
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<p>Stress–strain–temperature diagram of NiTi. Reproduced with permission [<a href="#B136-bioengineering-11-00983" class="html-bibr">136</a>]. Copyright 2013, Elsevier.</p>
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<p>A finite element model utilizing the COMSOL Multiphysics<sup>®</sup> numerical software has been constructed for the Palmaz Schatz stent, focusing on analyzing one twenty-fourth of the stent’s geometry. Reproduced with permission [<a href="#B196-bioengineering-11-00983" class="html-bibr">196</a>]. Copyright 2021, Elsevier.</p>
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<p>Stent size variation: (<b>a</b>) unit cell, (<b>b</b>) 2D pattern of cell, and (<b>c</b>) stent. Reproduced with permission [<a href="#B197-bioengineering-11-00983" class="html-bibr">197</a>]. Copyright 2020, Elsevier.</p>
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<p>(<b>a</b>) A thorough investigation into post-processing analyses has been undertaken for four specific types of expandable stents, namely PLLA, nitinol, stainless steel (SS), and pure Mg, (<b>b</b>) along with an assessment covering six distinct geometrical variations in these stents. (<b>c</b>) These analyses encompass the evaluation of area percentages via histograms, with a primary focus on instances of adverse low WSS (&lt;0.5 Pa) at four critical time points during a cardiac cycle. (<b>d</b>) Contour maps illustrate the distribution of time-averaged wall shear stress (TAWSS) on the lumen wall. Reproduced with permission [<a href="#B199-bioengineering-11-00983" class="html-bibr">199</a>]. Copyright 2019, Frontiers.</p>
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<p>(<b>a</b>) Normalized effective wall shear stress (WSS), (<b>b</b>) normalized average axial WSS, (<b>c</b>) normalized average transverse WSS, and (<b>d</b>) ratio of normalized axial WSS to transverse WSS plotted for the various stent design types. Additionally, the percentage area of the region between struts with averaged low WSS ((<b>e</b>) &lt;5 dynes/cm<sup>2</sup> and (<b>f</b>) &lt;2.5 dynes/cm<sup>2</sup>) for more than 50% of the flow cycle in the different stent design types. Reproduced with permission [<a href="#B204-bioengineering-11-00983" class="html-bibr">204</a>]. Copyright 2009, The American Society of Mechanical Engineers.</p>
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<p>(<b>a</b>) This section presents a comprehensive comparative analysis of radial-force responses, drawing from both experimental and computational data, for wire-braided stents with braid angles of α = 45°. (<b>b</b>) Juxtapose computational bending deformations. (<b>c</b>) Comparison of experimental and computational data. (<b>d</b>) Stent elongation at 2.4 mm. Reproduced with permission [<a href="#B205-bioengineering-11-00983" class="html-bibr">205</a>]. Copyright 2021, Elsevier.</p>
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<p>(<b>a</b>) This section presents a comprehensive comparative analysis of radial-force responses, drawing from both experimental and computational data, for wire-braided stents with braid angles of α = 45°. (<b>b</b>) Juxtapose computational bending deformations. (<b>c</b>) Comparison of experimental and computational data. (<b>d</b>) Stent elongation at 2.4 mm. Reproduced with permission [<a href="#B205-bioengineering-11-00983" class="html-bibr">205</a>]. Copyright 2021, Elsevier.</p>
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<p>The stent deployment detection system, as elaborated in the research conducted by Xu et al. reproduced with permission [<a href="#B213-bioengineering-11-00983" class="html-bibr">213</a>]. Copyright 2020, John Wiley &amp; Sons, Inc. (<b>a</b>) The experimental setup includes a stent and an RF-based sensor. The sensor is responsible for transmitting and receiving an amplitude-modulated signal, with the received signal being influenced by the shape of the stent. (<b>b</b>) The study workflow begins with data collection using the RF-based sensor for four distinct classes. A novel deep learning model, named StentNet, is introduced to detect stent deployment. (<b>c</b>) Data are collected in four different cases: no deployment (0 cm), partial deployment (1 cm), full deployment (3 cm), and full deployment with compression in the center. (<b>d</b>) Visualization of the four data classes shows the reflection power intensity, where darker colors represent higher reflection power.</p>
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<p>(<b>a</b>) macrofluidic flow chambers modeling the left anterior descending coronary (left), carotid (middle) and femoral (right) arteries, and (<b>b</b>) shear rate distributions within the models: extracted from CFD models. Reproduced with permission [<a href="#B243-bioengineering-11-00983" class="html-bibr">243</a>]. Copyright 2024, CellPress.</p>
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<p>SEM images depicting platelet aggregates on a carotid stent after perfusion with blood for 1 h. (<b>a</b>) Aggregates are observed at the intersection of the stent meshes and (<b>b</b>) composed of tightly packed platelets. Reproduced with permission [<a href="#B243-bioengineering-11-00983" class="html-bibr">243</a>]. Copyright 2024, CellPress.</p>
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<p>Schematic of laser powder bed fusion process to fabricate stent. Reproduced with permission [<a href="#B30-bioengineering-11-00983" class="html-bibr">30</a>]. Copyright 2022, Elsevier.</p>
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32 pages, 25612 KiB  
Article
Numerical and Experimental Validation for Connecting Nature with Architecture by Mimicking Cranium into a Shell Roof
by Pennarasi Gunasekaran and P. R. Kannan Rajkumar
Buildings 2024, 14(9), 2966; https://doi.org/10.3390/buildings14092966 - 19 Sep 2024
Viewed by 567
Abstract
This study focuses on a structural element bio-mimicked from the human cranium (HC) into a shell element. As the HC is effective in resisting intracranial pressure developed by the brain, a water tank was considered to use a bio-mimicked shape of a shell [...] Read more.
This study focuses on a structural element bio-mimicked from the human cranium (HC) into a shell element. As the HC is effective in resisting intracranial pressure developed by the brain, a water tank was considered to use a bio-mimicked shape of a shell as a roof. An optimized numerical model was validated experimentally and compared with a conventional specimen. The structural behavior of the bio-mimicked specimen is similar and performs more efficiently than the conventional specimen in capacity ratio, crack formation, and load-carrying capacity. Methodology followed: A Computed Tomography (CT) scan of the HC was obtained in Digital Imaging and Communications in Medicine (DICOM) format for finite element analysis (FEA). From the geometric parameters of the HC, the radius of the curvature-to-thickness ratio was derived for the shell. The span and thickness of the shell under two criteria were considered. The spherical and circular shell behaviors were found to be similar to those of the HC, whereas the elliptical shell behavior was not. We studied the shape effect of the HC with the conventional slab and found that the HC shape has an impact on the behavior and is the most efficient. A bio-mimicked mono column was considered as a supporting column for the water tank and analyzed. Overall, adopting this bio-mimicking of the HC into the shell roof connects nature with sustainable architecture. Full article
(This article belongs to the Section Building Structures)
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Figure 1
<p>(<b>a</b>) L’Hemisferic, Spain, inspired by (<b>b</b>) human eye shape [<a href="#B5-buildings-14-02966" class="html-bibr">5</a>].</p>
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<p>(<b>a</b>) The Egg Theatre, New York; (<b>b</b>) Eggshell; and (<b>c</b>) City Hall, London [<a href="#B5-buildings-14-02966" class="html-bibr">5</a>].</p>
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<p>(<b>a</b>) Skull of human (cranium) and (<b>b</b>) line diagram of shell.</p>
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<p>Shell shapes considered: (<b>a</b>) spherical, (<b>b</b>) circular, and (<b>c</b>) elliptical.</p>
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<p>Shapes of column considered: (<b>a</b>) circle, (<b>b</b>) stepped, and (<b>c</b>) bio-mimicked femur bone.</p>
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<p>(<b>a</b>) 3D model of cranium, (<b>b</b>) imported model, and (<b>c</b>) triangular mesh.</p>
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<p>Modeled shells, (<b>a</b>) spherical, (<b>b</b>) circular, and (<b>c</b>) elliptical.</p>
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<p>(<b>a</b>) Pressure on the external face and (<b>b</b>) fixed at base.</p>
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<p>Analysis of cranium: (<b>a</b>) equivalent stress and (<b>b</b>) displacement.</p>
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<p>For the S5 model: (<b>a</b>) equivalent stress pattern and (<b>b</b>) displacement pattern.</p>
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<p>Displacement vs. thickness: (<b>a</b>) for <math display="inline"><semantics> <mrow> <mstyle scriptlevel="0" displaystyle="true"> <mfrac> <mrow> <mi>R</mi> </mrow> <mrow> <mi>t</mi> </mrow> </mfrac> </mstyle> </mrow> </semantics></math> 10.803 and (<b>b</b>) for <math display="inline"><semantics> <mrow> <mstyle scriptlevel="0" displaystyle="true"> <mfrac> <mrow> <mi>R</mi> </mrow> <mrow> <mi>t</mi> </mrow> </mfrac> </mstyle> </mrow> </semantics></math> 11.101.</p>
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<p>Displacement vs. span: (<b>a</b>) for <math display="inline"><semantics> <mrow> <mstyle scriptlevel="0" displaystyle="true"> <mfrac> <mrow> <mi>R</mi> </mrow> <mrow> <mi>t</mi> </mrow> </mfrac> </mstyle> </mrow> </semantics></math> 10.803 and (<b>b</b>) for <math display="inline"><semantics> <mrow> <mstyle scriptlevel="0" displaystyle="true"> <mfrac> <mrow> <mi>R</mi> </mrow> <mrow> <mi>t</mi> </mrow> </mfrac> </mstyle> </mrow> </semantics></math> 11.101.</p>
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<p>Equivalent stress vs. thickness: (<b>a</b>) for <math display="inline"><semantics> <mrow> <mstyle scriptlevel="0" displaystyle="true"> <mfrac> <mrow> <mi>R</mi> </mrow> <mrow> <mi>t</mi> </mrow> </mfrac> </mstyle> </mrow> </semantics></math> 10.803 and (<b>b</b>) for <math display="inline"><semantics> <mrow> <mstyle scriptlevel="0" displaystyle="true"> <mfrac> <mrow> <mi>R</mi> </mrow> <mrow> <mi>t</mi> </mrow> </mfrac> </mstyle> </mrow> </semantics></math> 11.101.</p>
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<p>Equivalent stress vs. span: (<b>a</b>) for <math display="inline"><semantics> <mrow> <mstyle scriptlevel="0" displaystyle="true"> <mfrac> <mrow> <mi>R</mi> </mrow> <mrow> <mi>t</mi> </mrow> </mfrac> </mstyle> </mrow> </semantics></math> 10.803 and (<b>b</b>) for <math display="inline"><semantics> <mrow> <mstyle scriptlevel="0" displaystyle="true"> <mfrac> <mrow> <mi>R</mi> </mrow> <mrow> <mi>t</mi> </mrow> </mfrac> </mstyle> </mrow> </semantics></math> 11.101.</p>
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<p>Conventional slab: (<b>a</b>) stress pattern and (<b>b</b>) displacement pattern.</p>
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<p>Conventional slab similar to conventional S5: (<b>a</b>) stress pattern and (<b>b</b>) displacement pattern.</p>
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<p>Water tank models with M21 shell roof: (<b>a</b>) circular, (<b>b</b>) stepped, and (<b>c</b>) bio-mimicked columns.</p>
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<p>Water tank models with M458 shell roof: (<b>a</b>) circular, (<b>b</b>) stepped, and (<b>c</b>) bio-mimicked columns.</p>
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<p>Stress pattern of M21 with bio-mimicked column: (<b>a</b>) filled with water, (<b>b</b>) half-filled with water, and (<b>c</b>) no water (empty).</p>
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<p>Displacement pattern of M21 with the bio-mimicked column with water: (<b>a</b>) filled with water, (<b>b</b>) half-filled with water, and (<b>c</b>) no water (empty).</p>
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<p>Critical stress comparison for S5 and C.</p>
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<p>Displacement comparison for S5 and C.</p>
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<p>Cross-sectional detailing of water tank specimen: (<b>a</b>) conventional and (<b>b</b>) bio-mimicked.</p>
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<p>Fabricated mold and reinforcement details for specimen.</p>
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<p>Conventional water tank specimen: (<b>a</b>) cast specimen and (<b>b</b>) numerical model.</p>
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<p>Bio-mimicked water tank specimen: (<b>a</b>) cast specimen and (<b>b</b>) numerical model.</p>
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<p>Curing of bio-mimicked and conventional water tanks.</p>
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<p>Cast bio-mimicked and conventional specimens.</p>
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<p>Test setup for conventional water tank.</p>
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<p>Test setup for bio-mimicked water tank.</p>
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<p>Formation of crack: (<b>a</b>) conventional and (<b>b</b>) bio-mimicked water tank.</p>
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<p>Stress failure pattern: (<b>a</b>) conventional and (<b>b</b>) bio-mimicked water tank.</p>
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<p>Load–displacement curve for experimental investigation.</p>
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<p>Load–displacement curve for numerical investigation.</p>
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<p>Tested specimens.</p>
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13 pages, 5413 KiB  
Article
Magnetically Driven Quadruped Soft Robot with Multimodal Motion for Targeted Drug Delivery
by Huibin Liu, Xiangyu Teng, Zezheng Qiao, Wenguang Yang and Bentao Zou
Biomimetics 2024, 9(9), 559; https://doi.org/10.3390/biomimetics9090559 - 16 Sep 2024
Viewed by 1386
Abstract
Untethered magnetic soft robots show great potential for biomedical and small-scale micromanipulation applications due to their high flexibility and ability to cause minimal damage. However, most current research on these robots focuses on marine and reptilian biomimicry, which limits their ability to move [...] Read more.
Untethered magnetic soft robots show great potential for biomedical and small-scale micromanipulation applications due to their high flexibility and ability to cause minimal damage. However, most current research on these robots focuses on marine and reptilian biomimicry, which limits their ability to move in unstructured environments. In this work, we design a quadruped soft robot with a magnetic top cover and a specific magnetization angle, drawing inspiration from the common locomotion patterns of quadrupeds in nature and integrating our unique actuation principle. It can crawl and tumble and, by adjusting the magnetic field parameters, it adapts its locomotion to environmental conditions, enabling it to cross obstacles and perform remote transportation and release of cargo. Full article
(This article belongs to the Special Issue Bio-Inspired Soft Robotics: Design, Fabrication and Applications)
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<p>Schematic representation of the two motion modes and targeted drug delivery of a magnetically driven quadruped soft robot.</p>
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<p>Preparation and assembly of magnetic quadruped soft robot. (<b>A</b>) Preparation of magnetic quadruped soft robot. (<b>B</b>) Assembly of magnetic quadruped soft robot.</p>
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<p>Material parameters and magnetic field properties and magnetically actuated deformation of magnetic quadruped soft robot. (<b>A</b>) Material parameters of N52 NdFeB magnetic particles. (<b>B</b>) Simulation of ENS in COMSOL with multi-cut magnetic field distribution. (<b>C</b>) Simulation of ENS in COMSOL with magnetic field distribution in the work plane. (<b>D</b>) Deformation effect of the robot in response to ENS actuation.</p>
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<p>Manipulation of two motion modes. (<b>A</b>) Manipulation signal and motion decomposition diagrams for two motion modes, (a) tumbling and (b) crawling. (<b>B</b>) Experimental screenshot of tumbling motion. (<b>C</b>) Experimental screenshot of crawling motion.</p>
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<p>Deformation response of the magnetically driven quadruped soft robot. (<b>A</b>) Bending response of the robot’s feet. (<b>B</b>) Response of the robot to tumbling deformation. (<b>C</b>) Conversion of magnetic field input current of solenoid coil versus magnetic field strength. (<b>D</b>) Driving effect of magnetic field strength on foot bending and top cover deformation.</p>
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<p>Kinematic characteristics of magnetically driven quadruped soft robot and its ability to traverse obstacles. (<b>A</b>) Effect of magnetic field strength and frequency on the robot’s crawling kinematic speed. (<b>B</b>) Effect of magnetic field strength and frequency on the robot’s tumbling kinematic speed. (<b>C</b>) The robot crawling through an obstacle. (<b>D</b>) The robot tumbling through an obstacle. (<b>E</b>) Performance comparison with reported robots.</p>
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<p>The magnetic quadruped soft robot transporting and releasing cargo. (<b>A</b>) Schematic diagram of the robot transporting and releasing cargo using tumbling and swinging motions. (<b>B</b>) Screenshots of experiments of the robot transporting and releasing cargo using tumbling and swinging motions.</p>
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38 pages, 2076 KiB  
Article
A Multi-Strategy Enhanced Hybrid Ant–Whale Algorithm and Its Applications in Machine Learning
by Chenyang Gao, Yahua He and Yuelin Gao
Mathematics 2024, 12(18), 2848; https://doi.org/10.3390/math12182848 - 13 Sep 2024
Viewed by 622
Abstract
Based on the principles of biomimicry, evolutionary algorithms (EAs) have been widely applied across diverse domains to tackle practical challenges. However, the inherent limitations of these algorithms call for further refinement to strike a delicate balance between global exploration and local exploitation. Thus, [...] Read more.
Based on the principles of biomimicry, evolutionary algorithms (EAs) have been widely applied across diverse domains to tackle practical challenges. However, the inherent limitations of these algorithms call for further refinement to strike a delicate balance between global exploration and local exploitation. Thus, this paper introduces a novel multi-strategy enhanced hybrid algorithm called MHWACO, which integrates a Whale Optimization Algorithm (WOA) and Ant Colony Optimization (ACO). Initially, MHWACO employs Gaussian perturbation optimization for individual initialization. Subsequently, individuals selectively undertake either localized exploration based on the refined WOA or global prospecting anchored in the Golden Sine Algorithm (Golden-SA), determined by transition probabilities. Inspired by the collaborative behavior of ant colonies, a Flight Ant (FA) strategy is proposed to guide unoptimized individuals toward potential global optimal solutions. Finally, the Gaussian scatter search (GSS) strategy is activated during low population activity, striking a balance between global exploration and local exploitation capabilities. Moreover, the efficacy of Support Vector Regression (SVR) and random forest (RF) as regression models heavily depends on parameter selection. In response, we have devised the MHWACO-SVM and MHWACO-RF models to refine the selection of parameters, applying them to various real-world problems such as stock prediction, housing estimation, disease forecasting, fire prediction, and air quality monitoring. Experimental comparisons against 9 newly proposed intelligent optimization algorithms and 9 enhanced algorithms across 34 benchmark test functions and the CEC2022 benchmark suite, highlight the notable superiority and efficacy of MSWOA in addressing global optimization problems. Finally, the proposed MHWACO-SVM and MHWACO-RF models outperform other regression models across key metrics such as the Mean Bias Error (MBE), Coefficient of Determination (R2), Mean Absolute Error (MAE), Explained Variance Score (EVS), and Median Absolute Error (MEAE). Full article
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<p>Flowchart of MHWACO.</p>
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<p>Exampleof Gaussian scatter search strategy.</p>
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<p>MHWACO overall flowchart.</p>
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<p>Comparison of MHWACO and EA’s variants: iteration graphs and box plots (f1–f34).</p>
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19 pages, 1460 KiB  
Article
Azimuthal Solar Synchronization and Aerodynamic Neuro-Optimization: An Empirical Study on Slime-Mold-Inspired Neural Networks for Solar UAV Range Optimization
by Graheeth Hazare, Mohamed Thariq Hameed Sultan, Dariusz Mika, Farah Syazwani Shahar, Grzegorz Skorulski, Marek Nowakowski, Andriy Holovatyy, Ile Mircheski and Wojciech Giernacki
Appl. Sci. 2024, 14(18), 8265; https://doi.org/10.3390/app14188265 - 13 Sep 2024
Viewed by 767
Abstract
This study introduces a novel methodology for enhancing the efficiency of solar-powered unmanned aerial vehicles (UAVs) through azimuthal solar synchronization and aerodynamic neuro-optimization, leveraging the principles of slime mold neural networks. The objective is to broaden the operational capabilities of solar UAVs, enabling [...] Read more.
This study introduces a novel methodology for enhancing the efficiency of solar-powered unmanned aerial vehicles (UAVs) through azimuthal solar synchronization and aerodynamic neuro-optimization, leveraging the principles of slime mold neural networks. The objective is to broaden the operational capabilities of solar UAVs, enabling them to perform over extended ranges and in varied weather conditions. Our approach integrates a computational model of slime mold networks with a simulation environment to optimize both the solar energy collection and the aerodynamic performance of UAVs. Specifically, we focus on improving the UAVs’ aerodynamic efficiency in flight, aligning it with energy optimization strategies to ensure sustained operation. The findings demonstrated significant improvements in the UAVs’ range and weather resilience, thereby enhancing their utility for a variety of missions, including environmental monitoring and search and rescue operations. These advancements underscore the potential of integrating biomimicry and neural-network-based optimization in expanding the functional scope of solar UAVs. Full article
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<p>Process flow charts. (<b>a</b>) The neural network optimization process using Slime Mold Optimization (SMO). (<b>b</b>) The environmental interaction process for terrain navigation and obstacle avoidance.</p>
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<p>Neural network layout.</p>
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<p>VLM discretization scheme (x, y, z in meters).</p>
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<p>Optimization results: (<b>a</b>) exploration vs. exploitation and (<b>b</b>) runtime.</p>
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15 pages, 11898 KiB  
Review
The ‘Nature’ of Vertical School Design—An Evolving Concept
by Alan J. Duffy
Architecture 2024, 4(3), 730-744; https://doi.org/10.3390/architecture4030038 - 12 Sep 2024
Viewed by 1273
Abstract
Successful urban school design includes green space to counterpoint the built form in cities, where parks and reserves are well frequented. Further integration of landscape and buildings is an aspect of urban development that could improve how architecture is experienced by the wider [...] Read more.
Successful urban school design includes green space to counterpoint the built form in cities, where parks and reserves are well frequented. Further integration of landscape and buildings is an aspect of urban development that could improve how architecture is experienced by the wider community. Above all, evidence shows that it enhances the health and wellbeing of inhabitants. By providing green space in buildings, nature can be accessed more directly by its occupants and allow connection with nature to occur more easily. Integrating nature with architecture can improve a building’s self-regulation, energy consumption, and overall performance. Architecture that integrates nature can have a distinctive appearance and character. The co-existence of bricks and mortar with plants and vegetation is one example of integration, whereas the use of natural materials such as timber as part of the building fabric can create distinctive architecture. It is this individuality that can provide a sense of identity to local communities. Access to the outdoors in urban settings is a critical requirement for successful urban school design. This paper focuses on the architectural practise of designing biophilic schools and illustrates how optimising playground opportunities can provide the highly sought-after connection between architecture and nature. Connecting classrooms and pedagogy to the outside environment during the design phases of projects can create unique responses to a place, enhancing the learning experience in environments where architecture and nature can be informed by emerging biophilic evidence. This study strives to develop a strategy where educational clients can be convinced to actively embrace a biophilic school approach. It also seeks to convince architects to adopt a biophilic approach to school design across design studios using the emerging evidence based on biophilia and biomimicry. Full article
(This article belongs to the Special Issue Biophilic School Design for Health and Wellbeing)
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<p>Biomimicry design spiral (source: McGregor, 2014).</p>
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<p>Urban school with elevated outdoor space (source: author, 2019).</p>
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<p>The connected façade and courtyard space. (Source: author, 2019).</p>
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<p>The window nook (source: author, 2019).</p>
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<p>Flinders University’s Health and Medical Research Building, Adelaide, South Australia. (Source: author, 2024).</p>
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<p>An illustration of a biophilic building concept for a tropical climate (source: Architectus, 2022).</p>
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<p>Urban school plan layout diagram. (Source: author, 2022).</p>
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<p>An urban school where the play space becomes the building façade. (Source: author, 2022).</p>
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<p>Designing from the inside out by bringing the outside in—biophilic urban schools. (Source: author, 2019).</p>
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32 pages, 5494 KiB  
Article
Innovation Inspired by Nature: Applications of Biomimicry in Engineering Design
by Teresa Aguilar-Planet and Estela Peralta
Biomimetics 2024, 9(9), 523; https://doi.org/10.3390/biomimetics9090523 - 30 Aug 2024
Viewed by 3673
Abstract
Sustainable development is increasingly driving the trend toward the application of biomimicry as a strategy to generate environmentally friendly solutions in the design of industrial products. Nature-inspired design can contribute to the achievement of the Sustainable Development Goals by improving efficiency and minimizing [...] Read more.
Sustainable development is increasingly driving the trend toward the application of biomimicry as a strategy to generate environmentally friendly solutions in the design of industrial products. Nature-inspired design can contribute to the achievement of the Sustainable Development Goals by improving efficiency and minimizing the environmental impact of each design. This research conducted an analysis of available biomimetic knowledge, highlighting the most applied tools and methodologies in each industrial sector. The primary objective was to identify sectors that have experienced greater adoption of biomimicry and those where its application is still in its early stages. Additionally, by applying the available procedures and tools to a selected case study (technologies in marine environments), the advantages and challenges of the methodologies and procedures were determined, along with potential gaps and future research directions necessary for widespread implementation of biomimetics in the industry. These results provide a comprehensive approach to biomimicry applied to more sustainable practices in product design and development. Full article
(This article belongs to the Special Issue Biomimetics—A Chance for Sustainable Developments: 2nd Edition)
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<p>Potential application of bioinspired items in product design.</p>
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<p>Research methodology, stage 1.</p>
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<p>Research methodology, stage 2.</p>
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<p>Application sectors according to AskNature.</p>
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<p>(<b>a</b>) Biomimicry publications by year of publication; (<b>b</b>) Results categorized by sector; (<b>c</b>) Results according to the type of publications.</p>
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<p>(<b>a</b>) The scope of the investigation; (<b>b</b>) Applications of biomimicry according to area of knowledge; (<b>c</b>) Proposals for methods and tools; (<b>d</b>) Selection of methodologies.</p>
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<p>Results classified by area of knowledge and year.</p>
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<p>Biomimicry Design Spiral.</p>
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<p>The Manufacturing Process of Piñatex.</p>
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<p>Design Spiral results.</p>
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<p>Alternative generated with the biomimicry taxonomy.</p>
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<p>Alternatives generated with BioTRIZ.</p>
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