Search Results (51,928)

Workplace physical activity programs (WPAPs) are increasingly being recognized for improving employee health, though the results remain inconsistent. Universities provide favorable settings for WPAPs. This study examined the effects of a 24-week circuit training and mobility program on the physical fitness (PF) and body composition of university employees. Thirty-eight university employees (9 males and 29 females; 51.5 ± 12.6 years) followed a 24-week training program consisting of two circuit training sessions and one mobility session per week. PF (including cardiorespiratory fitness (CRF), grip strength, shoulder mobility, core endurance, lower limb strength, and balance) body composition, anthropometric variables, and physical activity (PA) levels were assessed at baseline (T0), 12 weeks (T1), and 24 weeks (T2). CRF, strength, mobility, and core endurance significantly improved. A body composition analysis indicated a decrease in fat mass and an increase in lean mass at T2. Minor changes were observed in anthropometric variables. Furthermore, PA levels increased throughout the intervention. The 24-week WPAP improved the PF and body composition of university employees. Full article

(1) Background: Institutionalized older adults represent a vulnerable population. It is important to understand that higher levels of physical activity in older adults are associated with less risk of cardiovascular diseases, better cognition, and lower inflammaging and sarcopenia levels. The main objective was to evaluate the differences in health parameters in institutionalized older adults who perform different levels of weekly physical activity. The secondary objective was to analyze if weekly physical activity levels are a predictor of health parameters. (2) Methods: A cross-sectional observational study was conducted in nursing homes with adults over 75 years of age. A total of 76 participants was divided into three groups based on their weekly physical exercise frequency (1 day/week, 2 days/week, and 3 days/week). We measured demographic and anthropometric variables, along with cognitive level through the Mini Exam of Lobo. Handgrip strength, leg muscle strength, and power were also evaluated, and C-reactive protein levels were assessed through blood tests. Physical performance was measured using the Short Physical Performance Battery and walking speed. (3) Results: Significant differences were found in body mass index (p < 0.01; ES = 0.96), muscular strength (p < 0.01; ES = 0.70 ), and power (p < 0.01; ES = 1.09), Short Physical Performance Battery (p < 0.01; ES = 1.46) and walking speed (p < 0.01; ES = 0.87), cognitive function (p < 0.01; ES = 1.21), and C-reactive protein levels (p < 0.01; ES = 1.73), favoring the group who performed 3 days/week of physical activity. (4) Conclusions: Institutionalized older adults with three days per week of physical activity have greater physical and muscle function and less cognitive decline. Three days of weekly physical activity is associated with systemic inflammation and better cognitive status in institutionalized older adults. Full article

Background/Objectives: Improving food safety practices among young adults is critical to public health, but effective communication strategies are under-researched. This study investigated the effectiveness of a 12-day message-based intervention to promote safe food handling practices using a randomised controlled trial. Methods: A total of 588 participants (aged 18 to 35 years) were randomly assigned to one of four experimental conditions or to a control group. Participants in the intervention groups received daily messages via a mobile app, while the control group received no messages. The intervention combined belief-based content to raise awareness with skill-based content to teach practical food handling, framed by either positive or negative emotional appeals. The experimental conditions differed in message congruence, with belief-based and skill-based content framed either consistently (both positive or both negative) or inconsistently (one positive, one negative). To assess the impact of the intervention, self-reported adherence to food safety practices, food safety awareness, and self-efficacy were measured at baseline and post-intervention. Results: The results showed that the intervention significantly improved food safety practices, especially when the messages were congruent in valence. Pre-intervention self-efficacy moderated the effects, with higher self-efficacy increasing receptivity to certain messages, while lower self-efficacy benefited from a different framing. Self-efficacy, but not awareness, mediated behaviour change, highlighting its key role in the success of the intervention. Conclusions: These results emphasise the importance of message valence congruence and individual self-efficacy levels in designing effective food safety interventions. Future research should investigate long-term intervention effects, adaptive mHealth strategies, and tailored communication approaches to maximise engagement and sustained behaviour change. Full article

Headache and facial pain syndromes are frequently observed in people with multiple sclerosis (MS), often affecting young adults during pivotal stages of their lives. These conditions can disrupt their ability to work, maintain relationships, and engage in daily activities, leading to significant socio-economic and personal challenges. This narrative review summarizes key epidemiological data and diagnostic insights into headache and facial pain disorders in people with MS. It addresses the complexities of diagnosing these overlapping conditions and highlights specific therapeutic considerations. Full article

Background and Objectives: The main objectives of our study were to assess sexual dimorphism and to compare the facial height, as well as the anteroposterior width of the upper airway, within adult Caucasians diagnosed with skeletal Class I and skeletal Class III malocclusion, based on a number of angular and linear cephalometric parameters. Materials and Methods: One hundred lateral cephalograms were selected from orthodontic adult Caucasian patients from western Romania. Several angular parameters (SNA, SNB, ANB, FMA, Y–FH, Ba–S–PNS and NL–ML angles) and linear parameters (total, upper and lower anterior facial height—TAFH, UAFH, LAFH; total posterior facial height—TPFH) were analysed for each case. The upper airway width parameters included the width of the nasopharynx, as well as the upper, middle and lower pharyngeal airway width (UPAW, MPAW and LPAW). Results: Distinct sexual dimorphism was observed regarding the vertical cephalometric parameters within both Class I and Class III groups, with males exhibiting significantly larger facial height parameters, while females demonstrated larger nasopharyngeal depth angles (Ba–S–PNS). The Y–FH angle had significantly higher values in Class I than in Class III subjects, regardless of sex. Upper airway dimensions showed sexual dimorphism specifically in Class III subjects, with females exhibiting larger UPAW values than males. The inter-class comparisons showed larger values for LPAW, especially in females. Correlation analyses revealed no statistically significant relationships between the vertical and the upper airway parameters in Class I subjects. UPAW showed a tendency to decrease in Class III subjects as TAFH and LAFH increased. Ba–S–PNS showed consistent negative correlations with the vertical dimensions in both groups. Conclusions: These findings suggest that skeletal Class I and Class III malocclusions exhibit not only different sagittal relationships, but also distinctive, sex-related vertical skeletal patterns within each group, and therefore it would be advised that male and female patients should be diagnosed and treated according to separate protocols. In our population, Class III males are more likely to require orthognathic surgery, in addition to orthodontic treatment, with a more reserved prognosis and they might have a higher risk of OSA or other respiratory disorders in comparison with Class III females. Full article

Background/Objectives: Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancer cases and is a leading cause of morbidity and mortality worldwide. Between 35% and 65% of NSCLC patients experience nutritional problems or malnutrition, which significantly affects their prognosis and quality of life. This study aims to describe the nutritional status and body composition of NSCLC patients treated with osimertinib, an oral tyrosine kinase inhibitor, while also assessing the prevalence of sarcopenia, presarcopenia, and dynapenia. Additionally, we explore the relationship between dose-limiting toxicities (DLTs) and nutritional status, as well as the impact of nutritional status on quality of life using the EQ-5D scale. Methods: A cross-sectional, observational study was conducted in 25 adult patients diagnosed with NSCLC treated with osimertinib under pharmacotherapeutic follow-up in the Pharmacy Consultations of a tertiary-level hospital. Anthropometric parameters, body composition (via bioimpedance analysis), and muscle functionality (via dynamometry) were assessed. Quality of life was evaluated using the EQ-5D scale. Results: The results showed that 36% of patients were malnourished, 4% had sarcopenia, 8% were presarcopenic, and 20% had dynapenia. Patients with DLTs exhibited significantly lower values of fat-free mass and the fat-free mass index, suggesting a relationship between low muscle mass and increased toxicities. Conclusions: These findings underscore the importance of early, individualized nutritional interventions in NSCLC patients treated with osimertinib to improve nutritional status and optimize oncological outcomes. Further research with larger cohorts and longitudinal designs is necessary to confirm these findings. Full article

Osteosarcoma (OS) is the most common primary malignant bone tumor, predominantly affecting children, adolescents, and young adults. Epithelial–mesenchymal transition (EMT), a process in which epithelial cells lose their cell–cell adhesion and gain migratory and invasive properties, has been extensively studied in various carcinomas. However, its role in mesenchymal tumors like osteosarcoma remains less explored. EMT is increasingly recognized as a key factor in the progression of osteosarcoma, contributing to tumor invasion, metastasis, and resistance to chemotherapy. This narrative review aims to provide a comprehensive overview of the molecular mechanisms driving EMT in osteosarcoma, highlighting the involvement of signaling pathways such as TGF-β, transcription factors like Snail, Twist, and Zeb, and the role of microRNAs in modulating EMT. Furthermore, we discuss how EMT correlates with poor prognosis and therapy resistance in osteosarcoma patients, emphasizing the potential of targeting EMT for therapeutic intervention. Recent advancements in understanding EMT in osteosarcoma have opened new avenues for treatment, including EMT inhibitors and combination therapies aimed at overcoming drug resistance. By integrating biological insights with clinical implications, this review underscores the importance of EMT as a critical process in osteosarcoma progression and its potential as a therapeutic target. Full article

Background/Objectives: Direct oral anticoagulants (DOACs), when compared to the Vitamin K antagonist (VKA) warfarin, exhibit greater safety and effectiveness. However, DOACs may still have potential drug–drug interactions that result in major bleeding events. There is a paucity of studies on medications that have pharmacodynamic interactions with DOACs, such as selective serotonin reuptake inhibitors (SSRIs). This study evaluates the potential major bleeding risk associated with the concomitant use of SSRIs among nonvalvular atrial fibrillation (NVAF) patients who were receiving DOACs. Methods: Adult patients receiving DOACs with consecutive NVAF diagnoses were identified from the Penn State Health Electronic Health Records from 2013 to 2023. These patients were then checked for exposure (i.e., concomitant use of SSRIs). The outcome was time to the first occurrence of a major bleeding event, with a follow-up from the first DOAC prescription until a major bleeding event, death, or end of follow-up. This retrospective cohort study used a Cox cause-specific proportional hazard model to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) with inverse probability of treatment weighting to adjust for measurable confounding factors (e.g., demographics, comorbidities, comedications). Results: A total of 8657 NVAF patients who were receiving DOACs were identified. The mean age was 70.3 ± 11.95 years, and females comprised 39.8% of the study population. The baseline CHA2DS2-VASc score was 3.77 ± 1.76, and the HAS-BLED score was 2.98 ± 1.27. Among these patients, 2649 (30.6%) were co-prescribed with SSRIs. The unadjusted hazard ratio for SSRIs was 0.87 (95% CI: 0.76–0.99) and the adjusted hazard ratio was 0.68 (95% CI: 0.59–0.78). Conclusions: In patients with NVAF receiving DOACs, concomitant use of SSRIs was not associated with a higher risk of major bleeding. Full article

Research has provided evidence of the protective characteristics of extended family for U.S. emerging adults, but no research has specifically explored cousin relationships. The current study fills this gap by analyzing qualitative data collected from 192 U.S. 18–29-year-old adults (M age = 25.6 years). As this topic is relatively unexplored, examining qualitative data provides scope and vocabulary for further exploration. Participants completed an online survey asking them to describe interactions with extended family, identifying 561 cousins (M age = 28.2 years). A thematic analysis based on the process defined by Braun and Clark generated four primary themes: (1) emerging adults feel varying degrees of closeness and distance with their cousins, (2) relational maintenance with cousins is both planned and incidental, (3) family membership provides resources, and (4) cousins share the same generational position. These results describe important characteristics of the cousin relationship, including moments of unexpected closeness and shared experience of family. The findings also highlight the relevance of sharing a similar life stage within the same family system. Practitioners can utilize findings to help clients identify extended family members that can be tapped for bonding and support. Full article

Existing virtual reality (VR) street view and 360-degree road view applications often rely on complex controllers or touch interfaces, which can hinder user immersion and accessibility. These challenges are particularly pronounced for under-represented populations, such as older adults and individuals with limited familiarity with digital devices. Such groups frequently face physical or environmental constraints that restrict their ability to engage in outdoor activities, highlighting the need for alternative methods of experiencing the world through virtual environments. To address this issue, we propose a VR street view application featuring an intuitive, gesture-based interface designed to simplify user interaction and enhance accessibility for socially disadvantaged individuals. Our approach seeks to optimize digital accessibility by reducing barriers to entry, increasing user immersion, and facilitating a more inclusive virtual exploration experience. Through usability testing and iterative design, this study evaluates the effectiveness of gesture-based interactions in improving accessibility and engagement. The findings emphasize the importance of user-centered design in fostering an inclusive VR environment that accommodates diverse needs and abilities. Full article

Territorial crustaceans exhibit a complex set of personality traits and behavioral characteristics that are critical for their survival, growth, and overall welfare. This study aimed to systematically investigate the interplay between two essential personality traits—boldness and aggression—in Chinese mitten crabs (Eriocheir sinensis), during various developmental stages under conditions of crowding stress and food odor stimuli. Using behavioral assays, we found that adults displayed significantly higher levels of boldness and aggression compared to juveniles. Notably, bold adult crabs demonstrated lower aggression than their shy counterparts, revealing a significant negative correlation between boldness and aggression under crowding stress. Furthermore, juvenile and adult crabs exhibited negative correlations between the stability of their boldness and aggression with individual levels of boldness and aggression, respectively. The study also found that while juvenile boldness did not significantly correlate with body size, larger individuals displayed higher boldness under stress, contrasting with adult crabs, where boldness negatively correlated with body size, although aggression levels were unaffected by size; the stability of adult boldness demonstrated a positive correlation with body size under crowding stress. These findings elucidate the intricate dynamics of personality traits in territorial crustaceans, laying the groundwork for future research into their adaptive behavioral strategies in response to environmental cues like group stress and food odors. Full article

Cancer literacy is essential for promoting preventive behaviors and making informed decisions for a healthier lifestyle. There are significant gaps in the knowledge of modifiable and non-modifiable cancer risk factors among university students. The objective of this study is to evaluate the level of cancer literacy, characterize motivations for volunteering, and explore possible associations between the variables, relating them to sociodemographic data. The sample comprised 308 higher education students aged 18 or above. A sociodemographic questionnaire, the Students Knowledge and Perceptions about Cancer test, and the Volunteer Functions Inventory were administered. The findings indicated higher levels of cancer literacy among females, students involved in volunteering, and those in the Medical and Health Sciences. Women placed more importance on experience, values, and growth functions in volunteering. The correlation between cancer literacy and motivations for volunteering proved to be significant for the experience and values functions. The findings of this study are particularly pertinent to the field of education, highlighting the need for strategies aimed at the prevention of the disease and the training of young adults in cancer literacy. Full article

Human metapneumovirus (HMPV) and respiratory syncytial virus (RSV) are pneumoviruses causing lower respiratory tract infections, primarily in infants and children rather than in healthy adults. Human bronchial epithelial cells serve as a viral replication target and source of the innate immune response to these viruses. To better understand the immune responses induced by RSV and HMPV in the pediatric airway epithelium, we comparatively studied pediatric and adult epithelial responses. We used normal human bronchial epithelial (NHBE) cells cultured in an air–liquid interface culture system (ALI), which helps to mimic the architecture of the human lower respiratory tract epithelium. Our results demonstrate differential viral replication patterns and reduced interferons; and inflammatory cytokines’ expression in pediatric cells compared to adult cells. However, pediatric epithelial cells expressed an increased mucus response and induced a stronger pro-inflammatory response in monocyte-derived dendritic cells. These findings reveal age-dependent immune epithelial responses that may contribute to more severe infections by HMPV and RSV. Full article

Background: Adequate levels of leisure-time exercise (LTE) are associated with mental health benefits. Despite increased research in recent years through randomized controlled trials (RCTs), a systematic literature review aggregating these findings is lacking. Here, we examined publication trends, impact, and research gaps regarding LTE’s effects on mental health in the form of a bibliometric analysis. Methods: Five electronic databases (PubMed, EMBASE, Web of Science, Ovid Medline, and the Cumulative Index for Nursing and Allied Health Literature) were searched from their inception until 20 November 2024. Citations were independently screened by two authors and included based on pre-determined eligibility criteria. Bibliometric analysis was conducted using SciVal and VOSviewer under five themes: (1) descriptive analysis, (2) network analysis, (3) thematic mapping, (4) co-citation and co-occurrence analysis, and (5) bibliometric coupling. Results: The systematic search identified 5792 citations, of which 78 RCTs met the inclusion criteria. Only one study was conducted in a low- or middle-income country. Sixty-four percent of studies were published in quartile-one journals. Most studies were, conducted in the United States, followed by Australia, Canada, and the United Kingdom. National collaborations yielded the highest citation rates, reflecting the influence of cultural and social norms on exercise and mental health. Research gaps were identified with regards to the validity of mental health measures, the paucity of data from low- and middle-income countries, and emerging research sources. Conclusions: This bibliometric analysis highlights the existing evidence on LTE’s impact on mental health and identifies areas for future research and policy. Trials exploring valid mental health outcomes, biomarkers such as mood and oxidative stress, and collaborative research are needed, particularly in underrepresented regions of the world. Full article

Background/Objective: Millions of children were infected with SARS-CoV-2, and a small proportion progressed to severe disease, especially those with underlying risk factors. Adult COVID-19 studies showed mortality benefits with Remdesivir. Data on Remdesivir use in pediatrics are limited. We report on the safety and tolerability of Remdesivir in pediatric patients seen at our institution. Methods: This was a retrospective cohort study of patients <19 years old with acute SARS-CoV-2 infection who received at least one dose of Remdesivir. Patients followed strict institutional guidelines for safety monitoring including standard clinical and laboratory daily observations. Demographics and underlying conditions were reported as averages; for laboratory values, linear regression was applied within a generalized linear mixed-effects model framework to evaluate the significance of changes in average levels over time. Results: We enrolled 318 patients with acute SARS-CoV2 infection from May 2020 to December 2022. In total, 53% were male, and the age range was distributed broadly. In total, 61% were school-aged children (28% 5–11 and 33% 12–18 years of age). In total, 62% of cases were Hispanic. The most common reasons for Remdesivir treatment included respiratory distress (201; 63%) and having high-risk underlying conditions (109; 34%). Therapy was completed as planned in 91% and discontinued early in 9%. Mean baseline, peak, and end of treatment values for AST were 57 (95% CI 53, 61), 79 (95% CI 73, 84) (p < 0.001), and 55 (51, 59) (p = 0.479); for ALT, they were 42 (38, 47), 59 (95% CI 52, 66) (p < 0.001), and 46 (95% CI 41, 52) (p = 0.054); and for bilirubin, they were 0.56 (95% CI 0.50, 0.62), 0.67 (95% CI 0.61, 0.74) (p < 0.001), and 0.44 (95% CI 0.40, 0.48) (p < 0.001), respectively. During Remdesivir treatment, we did not observe marrow suppression or renal toxicity. Conclusions: No clinically significant hematological or renal toxicity was noted. Mean liver enzymes increased modestly and returned to baseline without interrupting treatment. Remdesivir was well tolerated in patients <19 years old. Full article