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Medicina
Special Issues
New Insights into Plastic and Reconstructive Surgery
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New Insights into Plastic and Reconstructive Surgery

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Surgery".

Deadline for manuscript submissions: 15 April 2025 | Viewed by 196

Special Issue Editors

Dr. Francesco De Francesco

E-Mail Website
Guest Editor
Department of Reconstructive Surgery and Hand Surgery, AOU Ospedali Riuniti, Ancona, Italy
Interests: plastic surgery; aesthetic surgery; reconstructive surgery; breast reconstruction; regenerative surgery; hand surgery
Special Issues, Collections and Topics in MDPI journals
Dr. Michele Riccio

E-Mail Website
Guest Editor
1. Department of Reconstructive Surgery and Hand Surgery, AOU Ospedali Riuniti, Ancona, Italy
2. Accademia del Lipofilling, Research and Training Center in Regenerative Surgery, Jesi, Ancona, Italy
Interests: plastic surgery; aesthetic surgery; reconstructive surgery; breast reconstruction; breast augmentation; oncoplastic surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Background and History of the Topic:

Plastic and reconstructive surgery has a long and fascinating history, dating back thousands of years. The earliest evidence of reconstructive techniques is found in ancient Indian medical texts and Egyptian papyri, describing interventions for treating wounds and deformities. Over the centuries, this medical discipline has evolved significantly, especially during the 20th century, thanks to technological advancements, world wars, and a greater understanding of the anatomy and physiology of tissues. Today, plastic and reconstructive surgery not only deals with reconstructing damaged or missing body parts but also with aesthetic improvements, contributing to the quality of life of patients.

The Aim and Scope of the Special Issue:

This Special Issue aims to gather new insights, innovative methodologies, and recent advancements in plastic and reconstructive surgery. It seeks to provide a multidisciplinary platform for researchers, surgeons, and specialists in the field to share their experiences, discoveries, and challenges. We will cover a broad spectrum of topics, from advanced surgical techniques and the use of biomimetic materials to applications of digital and robotic technology, exploring how these innovations can be integrated into clinical practice to improve patient outcomes.

Cutting-Edge Research

We are excited to present cutting-edge research that explores new frontiers in plastic and reconstructive surgery. Among the research topics, we will include the following:

  • Advanced techniques in microsurgery and robotic
  • Innovations in tissue and organ
  • Developments in tissue engineering and regenerative
  • Psychological and social impacts of reconstructive and aesthetic
  • New methodologies for managing scars and
  • Use of 3D technologies and augmented reality in preoperative planning and
  • Comparative analyses of traditional and contemporary surgical

What Kind of Papers Are We Soliciting?

We invite original research contributions, systematic reviews, opinion articles, and clinical case reports on topics ranging from technical innovations to clinical applications in plastic and reconstructive surgery. Areas of interest include, but are not limited to, the following:

  • Development and evaluation of new surgical
  • Clinical studies on the efficacy and safety of new
  • Translational research linking basic discoveries to clinical
  • Application of bioengineering and nanomedicine in tissue
  • Advances in pre- and post-operative patient
  • Psychological and social impacts of aesthetic and reconstructive
  • Use of data and artificial intelligence to enhance the personalization and outcomes of

With this collection of articles, we hope to stimulate fruitful discussions and promote the adoption of evidence-based practices that can transform plastic and reconstructive surgery, bringing tangible benefits to patients worldwide.

Dr. Francesco De Francesco
Dr. Michele Riccio
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microsurgery
  • regenerative medicine
  • tissue engineering
  • robotic surgery
  • biomimetic materials
  • aesthetic surgery
  • wound healing
  • 3D printing
  • reconstructive techniques
  • psychological impacts

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

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Research

11 pages, 4951 KiB  
Article
Stem Cells Within Three-Dimensional-Printed Scaffolds Facilitate Airway Mucosa and Bone Regeneration and Reconstruction of Maxillary Defects in Rabbits
by Mi Hyun Lim, Jung Ho Jeon, Sun Hwa Park, Byeong Gon Yun, Seok-Won Kim, Dong-Woo Cho, Jeong Hak Lee, Do Hyun Kim and Sung Won Kim
Medicina 2024, 60(12), 2111; https://doi.org/10.3390/medicina60122111 - 23 Dec 2024
Abstract
Background and Objectives: Current craniofacial reconstruction surgical methods have limitations because they involve facial deformation. The craniofacial region includes many areas where the mucosa, exposed to air, is closely adjacent to bone, with the maxilla being a prominent example of this structure. [...] Read more.
Background and Objectives: Current craniofacial reconstruction surgical methods have limitations because they involve facial deformation. The craniofacial region includes many areas where the mucosa, exposed to air, is closely adjacent to bone, with the maxilla being a prominent example of this structure. Therefore, this study explored whether human neural-crest-derived stem cells (hNTSCs) aid bone and airway mucosal regeneration during craniofacial reconstruction using a rabbit model. Materials and Methods: hNTSCs were induced to differentiate into either mucosal epithelial or osteogenic cells in vitro. hNTSCs were seeded into polycaprolactone scaffold (three-dimensionally printed) that were implanted into rabbits with maxillary defects. Four weeks later, tissue regeneration was analyzed via histological evaluation and immunofluorescence staining. Results: In vitro, hNTSCs differentiated into both mucosal epithelial and osteogenic cells. hNTSC differentiation into respiratory epithelial cells was confirmed by Alcian Blue staining, cilia in SEM, and increased expression levels of FOXJ1 and E-cadherin through quantitative RT-PCR. hNTSC differentiation into bone was confirmed by Alizarin Red staining, increased mRNA expression levels of BMP2 (6.1-fold) and RUNX2 (2.3-fold) in the hNTSC group compared to the control. Four weeks post-transplantation, the rabbit maxilla was harvested, and H&E, SEM, and immunohistofluorescence staining were performed. H&E staining and SEM showed that new tissue and cilia around the maxillary defect were more prominent in the hNTSC group. Also, the hNTSCs group showed positive immunohistofluorescence staining for acetylated α-tubulin and cytokerin-5 compared to the control group. Conclusions: hNTSCs combined with PCL scaffold enhanced the regeneration of mucosal tissue and bone in vitro and promoted mucosal tissue regeneration in the in vivo rabbit model. Full article
(This article belongs to the Special Issue New Insights into Plastic and Reconstructive Surgery)
►▼ Show Figures

Figure 1

Figure 1
<p>Differentiation of hNTSCs into epithelial cells. (<b>A</b>) Alcian Blue staining revealing mucus production. Scale bars: 100 µm (<b>B</b>) SEM of cilia. Scale bars: 1.0 µm. (<b>C</b>) Real-time PCR data derived on days 0 and 45 after epithelial differentiation were induced. Bars: Relative expression levels (±SDs). * <span class="html-italic">p</span> &lt; 0.05.</p> Full article ">Figure 2
<p>Cell seeding into artificial maxillary grafts and pre-implantation culture. (<b>A</b>) hNTSC seeding into AMG in a spinner flask. hNTSC sheets covered the AMG after 3 days of culture in osteogenic induction medium before implantation of AMG-hNTSCs into rabbits. (<b>B</b>) An optical microscopic image of AMG seeded with hNTSCs after 3 days of culture (upper panel) and a confocal microscope image (with z-stack projections) after staining for F-actin (red). The nuclei were stained with DAPI (blue). Scale bars: 200 and 100 µm, respectively. (<b>C</b>) Images of CTRL (non-induced A-hNTSCs) and A-hNTSCs stained with Alizarin Red S, a dye used to detect calcium deposition, after 21 days of incubation in osteogenic differentiation medium. (<b>D</b>) The mineralization was quantified by extraction of Alizarin Red S dye using the CPC extraction method, and absorbance was measured at 570 nm. * <span class="html-italic">p</span> &lt; 0.05 compared with CTRL group. (<b>E</b>) The expression levels of BMP2 and RUNX2 after 21 days of incubation in osteogenic differentiation medium as revealed by real-time PCR. Bars: Relative expression levels (±SDs). ** <span class="html-italic">p</span> &lt; 0.01 and *** <span class="html-italic">p</span> &lt; 0.001.</p> Full article ">Figure 3
<p>Surgical and sacrifice procedures and evaluation of ciliary regeneration. (<b>A</b>) Images taken during surgery (<b>top</b>) and sacrifice (<b>bottom</b>). (<b>B</b>) H&amp;E staining of paraffin-embedded sections (scale bars: 1000 µm and 100 µm, respectively), and (<b>C</b>) SEM images obtained at 4 weeks after implantation of AMG or A-hNTSCs. Scale bars: 10 µm.</p> Full article ">Figure 4
<p>Immunohistofluorescence staining of hNTSCs in maxillary defects after implantation of AMG or A-hNTSCs. Confocal microscopy images (z-stack projections) of AMG and A-hNTSCs after staining of paraffin-embedded sections (a) with an antibody against (<b>A</b>) HuNu and (<b>B</b>) double-staining with antibodies against acetylated α-tubulin (green) and cytokeratin-5 (red) at 4 weeks. The nuclei were labeled with DAPI (blue). Scale bars: (<b>A</b>,<b>B</b>): upper panels 50 µm; lower panels 20 µm.</p> Full article ">
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