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KEGG   PATHWAY: sbia04148
Entry
sbia04148                   Pathway                                
Name
Efferocytosis - Syngnathoides biaculeatus (alligator pipefish)
Class
Cellular Processes; Transport and catabolism
Pathway map
sbia04148  Efferocytosis
sbia04148

Organism
Syngnathoides biaculeatus (alligator pipefish) [GN:sbia]
Gene
133490412  jak2a; tyrosine-protein kinase JAK2a isoform X1 [KO:K04447] [EC:2.7.10.2]
133490426  ptpn11a; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
133490439  ptpn11b; tyrosine-protein phosphatase non-receptor type 11b isoform X1 [KO:K07293] [EC:3.1.3.48]
133490494  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
133490686  atp2a2b; sarcoplasmic/endoplasmic reticulum calcium ATPase 2b [KO:K05853] [EC:7.2.2.10]
133490834  si:ch211-195b13.1; STKc_SGK domain-containing protein [KO:K13302] [EC:2.7.11.1]
133490857  [KO:K08524]
133490971  crkl; crk-like protein [KO:K04438]
133490991  [KO:K10223] [EC:1.14.99.38]
133491090  [KO:K04397] [EC:3.4.22.60]
133491101  megf10; multiple epidermal growth factor-like domains protein 10 [KO:K24068]
133491143  [KO:K26813]
133491196  rab14l; RAB14, member RAS oncogene family, like [KO:K07881]
133491219  xkr8.3; LOW QUALITY PROTEIN: XK-related protein 8.3 [KO:K26813]
133491247  ptger4b; prostaglandin E receptor 4 (subtype EP4) b [KO:K04261]
133491435  xkr6a; XK-related protein 6 isoform X1 [KO:K26811]
133491503  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
133491573  [KO:K04438]
133491855  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
133491929  vps11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179]
133492229  atp11a; phospholipid-transporting ATPase IH isoform X1 [KO:K26934]
133492470  atp8a2; LOW QUALITY PROTEIN: phospholipid-transporting ATPase IB [KO:K14802] [EC:7.6.2.1]
133492683  ppardb; peroxisome proliferator-activated receptor delta b isoform X1 [KO:K04504]
133492873  xkr9; XK-related protein 9 [KO:K26814]
133493062  vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
133493226  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
133493270  ano6; anoctamin-6 [KO:K19500]
133493551  cd36; platelet glycoprotein 4 [KO:K06259]
133493687  [KO:K04550]
133493753  [KO:K04441] [EC:2.7.11.24]
133493754  mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
133494552  [KO:K05641]
133494571  epoa; erythropoietin isoform X1 [KO:K05437]
133495032  slc2a1a; solute carrier family 2, facilitated glucose transporter member 1a [KO:K07299]
133495307  atp2a1l; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like [KO:K05853] [EC:7.2.2.10]
133495377  dock1; dedicator of cytokinesis protein 1 [KO:K13708]
133495402  epas1a; endothelial PAS domain-containing protein 1 isoform X1 [KO:K08268]
133495535  casp7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
133495594  [KO:K08765] [EC:2.3.1.21]
133495648  [KO:K06493]
133495747  [KO:K04392]
133495935  zgc:174164; disintegrin and metalloproteinase domain-containing protein 9 [KO:K06834] [EC:3.4.24.-]
133496015  arg1; arginase-1 [KO:K01476] [EC:3.5.3.1]
133496099  [KO:K04515] [EC:2.7.11.17]
133496315  adam17b; disintegrin and metalloproteinase domain-containing protein 17 [KO:K06059] [EC:3.4.24.86]
133496372  [KO:K17398] [EC:2.1.1.37]
133496411  thbs1b; thrombospondin-1 [KO:K16857]
133496552  xkr6b; XK-related protein 6b [KO:K26811]
133496596  [KO:K13302] [EC:2.7.11.1]
133496779  vps18; vacuolar protein sorting-associated protein 18 homolog isoform X1 [KO:K20181]
133497851  adam10a; disintegrin and metalloproteinase domain-containing protein 10 isoform X1 [KO:K06704] [EC:3.4.24.81]
133498062  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
133498097  [KO:K05725] [EC:2.7.10.2]
133498342  pros1; vitamin K-dependent protein S isoform X1 [KO:K03908]
133498343  gas6; growth arrest-specific protein 6 [KO:K05464]
133498349  tgfbrap1; transforming growth factor-beta receptor-associated protein 1 homolog [KO:K20177]
133498421  nr1h3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
133498496  [KO:K17253]
133498526  ano5b; anoctamin-5b [KO:K19480]
133498606  [KO:K24068]
133498981  [KO:K06834] [EC:3.4.24.-]
133499068  camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
133499096  [KO:K05853] [EC:7.2.2.10]
133499111  [KO:K07881]
133499334  jak2b; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
133499335  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
133499464  ch25hl3; cholesterol 25-hydroxylase [KO:K10223] [EC:1.14.99.38]
133499507  vps33a; vacuolar protein sorting-associated protein 33A isoform X1 [KO:K20182]
133499579  dusp2; LOW QUALITY PROTEIN: dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
133499819  ptger4a; prostaglandin E receptor 4 (subtype EP4) a [KO:K04261]
133500276  [KO:K05725] [EC:2.7.10.2]
133500567  [KO:K07887]
133500700  ptpn6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
133500785  rxrbb; retinoic acid receptor RXR-beta-B isoform X1 [KO:K08524]
133500796  [KO:K04596]
133500835  sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
133500846  [KO:K04446]
133500859  arnt; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
133501198  sgk2b; serine/threonine-protein kinase Sgk2b isoform X1 [KO:K13302] [EC:2.7.11.1]
133501712  megf11; multiple epidermal growth factor-like domains protein 11 isoform X1 [KO:K24068]
133501715  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
133501804  cpt1ab; carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
133501867  [KO:K00411] [EC:7.1.1.8]
133501927  elmo1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
133502062  pla2g15; group XV phospholipase A2 isoform X1 [KO:K06129] [EC:3.1.1.5]
133502076  mfge8b; milk fat globule EGF and factor V/VIII domain containing b isoform X1 [KO:K17253]
133502181  [KO:K06704] [EC:3.4.24.81]
133502343  mapk12a; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
133502473  dusp8a; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
133502477  [KO:K19503]
133502491  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
133502610  ano3; anoctamin-3 [KO:K19498]
133502611  ano5a; anoctamin-5 isoform X1 [KO:K19480]
133502632  [KO:K04596]
133502706  itgav; integrin alpha-V isoform X1 [KO:K06487]
133502724  bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
133502731  cpt1b; carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
133503094  calr; calreticulin [KO:K08057]
133503448  si:ch1073-396h14.1; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
133503494  s1pr1; sphingosine 1-phosphate receptor 1 [KO:K04288]
133503556  bsg; basigin [KO:K06535]
133503581  atp11b; phospholipid-transporting ATPase IF isoform X1 [KO:K26934]
133503693  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
133503758  [KO:K04261]
133503955  ptgs2b; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
133504078  abca7; phospholipid-transporting ATPase ABCA1 isoform X1 [KO:K05641]
133504302  hif1al; hypoxia inducible factor 1 subunit alpha, like [KO:K08268]
133504362  ano7; anoctamin-7 [KO:K19501]
133504495  [KO:K04272]
133504741  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
133504750  [KO:K05115] [EC:2.7.10.1]
133504753  slc66a1; lysosomal amino acid transporter 1 homolog [KO:K23678]
133504755  p2ry12; P2Y purinoceptor 12 [KO:K04298]
133504815  [KO:K03443]
133505007  crk; adapter molecule crk [KO:K04438]
133505182  [KO:K01370] [EC:3.4.22.36]
133505374  scarf1; scavenger receptor class F member 1 [KO:K24318]
133505663  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
133505703  [KO:K04718] [EC:2.7.1.91]
133505721  [KO:K05641]
133505781  pla2g6; 85/88 kDa calcium-independent phospholipase A2 [KO:K16343] [EC:3.1.1.4]
133506111  pecam1b; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
133506168  [KO:K03443]
133506504  [KO:K05870]
133506614  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
133506672  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
133507081  [KO:K07897]
133507121  pparg; peroxisome proliferator-activated receptor gamma [KO:K08530]
133507155  stab1; stabilin-1 [KO:K19020]
133507187  [KO:K07299]
133507461  il10; interleukin-10 [KO:K05443]
133507581  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
133507646  slc16a1a; monocarboxylate transporter 1a [KO:K08179]
133507753  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
133507829  mapkapk2a; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
133507937  [KO:K23285]
133507950  [KO:K07897]
133507960  [KO:K17332]
133507971  zgc:171775; STKc_p38 domain-containing protein isoform X1 [KO:K04441] [EC:2.7.11.24]
133508139  [KO:K04550]
133508410  [KO:K05641]
133508492  atp8a1; phospholipid-transporting ATPase IA isoform X1 [KO:K14802] [EC:7.6.2.1]
133509169  casp3b; caspase-3b isoform X1 [KO:K02187] [EC:3.4.22.56]
133509206  atp11c; phospholipid-transporting ATPase IG isoform X1 [KO:K26934]
133509367  sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
133509411  alox5a; polyunsaturated fatty acid 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
133509611  [KO:K04515] [EC:2.7.11.17]
133509814  ptger2a; prostaglandin E receptor 2a (subtype EP2) [KO:K04259]
133509908  vps16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
133509915  vps8; vacuolar protein sorting-associated protein 8 homolog isoform X1 [KO:K20178]
133509987  mertka; tyrosine-protein kinase Mer [KO:K05117] [EC:2.7.10.1]
133510141  [KO:K00461] [EC:1.13.11.34]
133510423  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
133510614  [KO:K09355]
133510706  [KO:K08057]
133510774  nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
133510802  ptger4c; prostaglandin E receptor 4 (subtype EP4) c isoform X1 [KO:K04261]
133510841  xkr4; XK-related protein 4 isoform X1 [KO:K26811]
133511438  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
133511718  [KO:K26811]
133511894  itgb5; integrin beta-5 [KO:K06588]
133512033  tmem30c; transmembrane protein 30C [KO:K26935]
133512296  [KO:K26934]
133512335  creb1b; cyclic AMP-responsive element-binding protein 1b [KO:K05870]
133512729  rab5b; ras-related protein Rab-5B [KO:K07888]
133512745  gulp1a; PTB domain-containing engulfment adapter protein 1 isoform X1 [KO:K23285]
133512752  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
133512929  hif1aa; hypoxia inducible factor 1 subunit alpha a isoform X1 [KO:K08268]
133513035  tyro3; tyrosine-protein kinase receptor TYRO3 isoform X1 [KO:K05116] [EC:2.7.10.1]
133513050  [KO:K16857]
133513341  tmem30b; cell cycle control protein 50B [KO:K26935]
133513405  [KO:K07299]
133513442  adam17a; disintegrin and metalloproteinase domain-containing protein 17a [KO:K06059] [EC:3.4.24.86]
133513470  vps39; vam6/Vps39-like protein [KO:K20183]
133513602  odc1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
133513610  tmem30aa; transmembrane protein 30Aa [KO:K26935]
133513653  dnmt3ab; DNA (cytosine-5)-methyltransferase 3A isoform X1 [KO:K17398] [EC:2.1.1.37]
133513796  arg2; arginase-2, mitochondrial isoform X1 [KO:K01476] [EC:3.5.3.1]
133514052  [KO:K08179]
133514091  rab5c; ras-related protein Rab-5C [KO:K07889]
133514115  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
133514160  cpt1a2b; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
133514225  epor; erythropoietin receptor [KO:K05079]
133514226  [KO:K05079]
133514281  atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
133514560  [KO:K04718] [EC:2.7.1.91]
133514719  [KO:K04392]
133514744  si:ch211-195b15.8; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
133514821  [KO:K26811]
133514892  cebpb; CCAAT/enhancer-binding protein beta [KO:K10048]
133515113  [KO:K06493]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
sbia00010  Glycolysis / Gluconeogenesis
sbia04140  Autophagy - animal
sbia04145  Phagosome
KO pathway
ko04148   

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