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KEGG   Homo sapiens (human): 2561
Entry
2561              CDS       T01001                                 
Symbol
GABRB2, DEE92, ICEE2
Name
(RefSeq) gamma-aminobutyric acid type A receptor subunit beta2
  KO
K05181  gamma-aminobutyric acid receptor subunit beta
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04723  Retrograde endocannabinoid signaling
hsa04726  Serotonergic synapse
hsa04727  GABAergic synapse
hsa05032  Morphine addiction
hsa05033  Nicotine addiction
Disease
H00606  Early infantile epileptic encephalopathy
H02150  Infantile or early childhood epileptic encephalopathy
Drug target
Abecarnil: D02594
Adinazolam (DG00911): D02770 D02771
Adipiplon: D08840
Alpidem: D02833
Alprazolam: D00225<JP/US>
Aminobutyric acid: D00058<JP>
Amobarbital (DG00916): D00555 D02252
Aprobarbital: D00698
Barbexaclone: D07298
Barbital: D01740
Bretazenil: D03155
Brexanolone: D11149
Bromazepam: D01245<JP>
Brotizolam: D01744<JP>
Butabarbital (DG01308): D00699 D03180
Butobarbital: D02618
Cenobamate: D11150<US>
Chlordiazepoxide (DG00908): D00267<JP> D00693<US>
Cinolazepam: D07328
Cipepofol: D12449
Clobazam: D01253<JP/US>
Clonazepam: D00280<JP/US>
Clotiazepam: D01328<JP>
Cloxazolam: D01268<JP>
Darigabat: D12146
Delorazepam: D07784
Dextofisopam: D03737
Diazepam: D00293<JP/US>
Estazolam: D00311<JP/US>
Eszopiclone: D02624<JP/US>
Ethyl loflazepate: D01293<JP>
Etizolam: D01514<JP>
Fludiazepam: D01354
Flumazenil: D00697<JP/US>
Flunitrazepam: D01230<JP>
Flurazepam (DG00919): D00329 D00695<US> D01408<JP>
Flutazolam: D01286<JP>
Flutoprazepam: D01279
Gaboxadol: D04282
Ganaxolone: D04300<US>
Glutethimide: D00532
Halazepam: D00338
Haloxazolam: D01758<JP>
Hexobarbital: D01071
Indiplon: D02640
Iomazenil: D02283<JP>
Ketazolam: D04650
Levotofisopam: D04721
Loprazolam (DG00921): D07326 D08145
Lorazepam: D00365<JP/US>
Lormetazepam: D01657<JP>
Medazepam (DG00909): D01292<JP> D04882
Meprobamate: D00376<US>
Metharbital: D01382
Methylphenobarbital: D00700
Mexazolam: D01316<JP>
Midazolam (DG00920): D00550<JP/US> D00696<US> D05028
Nimetazepam: D01593
Nitrazepam: D00531<JP>
Nordazepam: D08283
Ocinaplon: D02617
Oxazepam: D00464<US>
Oxazolam: D01278<JP>
Pagoclone: D02616
Panadiplon: D05346
Pazinaclone: D05378
Pentobarbital (DG00915): D00499 D00500<US> D02253<JP>
Phenobarbital (DG00845): D00506<JP> D00701<JP/US> D08356
Potassium clorazepate (DG01218): D00694<JP/US> D03562
Prazepam: D00470
Propofol (DG00797): D00549<JP/US> D04257
Quazepam: D00457<JP/US>
Remimazolam (DG03105): D10194<JP/US> D11788
Rilmazafone (DG01307): D01564<JP> D08481
Sarmazenil: D08507
Secobarbital (DG00917): D00430 D01310
Suritozole: D05980
Talbutal: D06887
Temazepam: D00370<US>
Thiamylal (DG01377): D00713<JP> D06106
Thiopental (DG00790): D00714<JP>
Tofisopam: D01254<JP>
Topiramate: D00537<JP/US>
Triazolam: D00387<JP/US>
Zolpidem (DG00922): D00706<JP/US> D08690
Zopiclone: D01372<JP>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2561 (GABRB2)
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    2561 (GABRB2)
   04726 Serotonergic synapse
    2561 (GABRB2)
   04723 Retrograde endocannabinoid signaling
    2561 (GABRB2)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    2561 (GABRB2)
   05033 Nicotine addiction
    2561 (GABRB2)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2561 (GABRB2)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  GABA-A
   2561 (GABRB2)
SSDB
Motif
Pfam: Neur_chan_memb Neur_chan_LBD
Other DBs
NCBI-GeneID: 2561
NCBI-ProteinID: NP_068711
OMIM: 600232
HGNC: 4082
Ensembl: ENSG00000145864
UniProt: P47870
Structure
Position
5:complement(161288436..161548404)
AA seq 512 aa
MWRVRKRGYFGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPV
AVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDT
YFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIES
YGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKR
NIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIP
YVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNKI
FYKDIKQNGTQYRSLWDPTGNLSPTRRTTNYDFSLYTMDPHENILLSTLEIKNEMATSEA
VMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPD
LTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN
NT seq 1539 nt   +upstreamnt  +downstreamnt
atgtggagagtgcggaaaaggggctactttgggatttggtccttccccttaataatcgcc
gctgtctgtgcgcagagtgtcaatgaccctagtaatatgtcgctggttaaagagacggtg
gatagactcctgaaaggctatgacattcgtctgagaccagattttggaggtccccccgtg
gctgtggggatgaacattgacattgccagcatcgatatggtttctgaagtcaatatggat
tataccttgacaatgtactttcaacaagcctggagagataagaggctgtcctataatgta
atacctttaaacttgactctggacaacagagtggcagaccagctctgggtgcctgatacc
tatttcctgaacgataagaagtcatttgtgcacggagtgactgttaagaaccgcatgatt
cgcctgcatcctgatggcaccgtcctttatggactcagaatcacaaccacagctgcctgc
atgatggacctaaggaggtacccactggatgaacaaaactgcaccttggaaattgagagc
tatggatacacaactgatgacattgagttttactggcgtggcgatgataatgcagtaaca
ggagtaacgaaaattgaacttccacagttctctattgtagattacaaacttatcaccaag
aaggttgttttttccacaggttcctatcccaggttatccctcagctttaagcttaagaga
aacattggctactttatcctgcaaacatacatgccttccatcctgattaccatcctctcc
tgggtctccttctggattaattacgatgcttcagctgcaagggtggcattaggaatcaca
actgtcctcacaatgaccacaatcaacacccacctccgggaaactctccctaaaatcccc
tatgtgaaggccattgacatgtacctgatggggtgctttgtcttcgttttcatggccctt
ctggaatatgccctagtcaactacatcttctttgggagggggccccaacgccaaaagaaa
gcagctgagaaggctgccagtgccaacaatgagaagatgcgcctggatgtcaacaagatt
ttttataaagatattaaacaaaatgggacccaatatcgatccttgtgggaccctactgga
aacctctccccaactagacggactaccaattacgatttctctctgtatacgatggacccc
catgagaacatcttactgagcactctcgagataaaaaatgaaatggccacatctgaggct
gtgatgggacttggagaccccagaagcacaatgctagcctatgatgcctccagcatccag
tatcggaaagctgggttgcccaggcatagttttggccgaaatgctctggaacgacatgtg
gcgcaaaagaaaagtcgcctgaggagacgcgcctcccaactgaaaatcaccatccctgac
ttgactgatgtgaatgccatagatcggtggtcccgcatattcttcccagtggttttttcc
ttcttcaacatcgtctattggctttattatgtgaactaa

  All links  
Disease (2)   
   OMIM (2)   
Gene (7)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (13)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (11)   
DNA sequence (41)   
   RefSeq(nuc) (11)   
   GenBank (15)   
   EMBL (15)   
3D Structure (19)   
   PDB (19)   
Protein domain (2)   
   Pfam (2)   
All databases (84)   

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