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KEGG   DRUG: Midazolam hydrochloride
Entry
D00696                      Drug                                   
Name
Midazolam hydrochloride (USAN);
Versed (TN)
Product
MIDAZOLAM HYDROCHLORIDE (Exela Pharma Sciences), MIDAZOLAM IN SODIUM CHLORIDE (WG Critical Care), SEIZALAM (Meridian Medical Technologies LLC)
  Generic
MIDAZOLAM (Almaject), MIDAZOLAM (Almaject), MIDAZOLAM (Athenex Pharmaceutical Division), MIDAZOLAM (Athenex Pharmaceutical Division), MIDAZOLAM (Civica), MIDAZOLAM (Fresenius Kabi USA), MIDAZOLAM (Fresenius Kabi USA), MIDAZOLAM (Fresenius Kabi USA), MIDAZOLAM (General Injectables and Vaccines), MIDAZOLAM (Henry Schein), MIDAZOLAM (Henry Schein), MIDAZOLAM (Henry Schein), MIDAZOLAM (Henry Schein), MIDAZOLAM (Hikma Pharmaceuticals USA), MIDAZOLAM (Hikma Pharmaceuticals USA), MIDAZOLAM (Hikma Pharmaceuticals USA), MIDAZOLAM (Hikma Pharmaceuticals USA), MIDAZOLAM (Micro Labs Limited), MIDAZOLAM (SOMERSET THERAPEUTICS), MIDAZOLAM (SOMERSET THERAPEUTICS), MIDAZOLAM (Sagent Pharmaceuticals), MIDAZOLAM (Sagent Pharmaceuticals), MIDAZOLAM (Steriscience Specialties Private Limited), MIDAZOLAM (Steriscience Specialties Private Limited), MIDAZOLAM HYDROCHLORIDE (A-S Medication Solutions), MIDAZOLAM HYDROCHLORIDE (A-S Medication Solutions), MIDAZOLAM HYDROCHLORIDE (ATLANTIC BIOLOGICALS CORP.), MIDAZOLAM HYDROCHLORIDE (American Health Packaging), MIDAZOLAM HYDROCHLORIDE (Belcher Pharmaceuticals), MIDAZOLAM HYDROCHLORIDE (Bryant Ranch Prepack), MIDAZOLAM HYDROCHLORIDE (Cardinal Health 107), MIDAZOLAM HYDROCHLORIDE (Gland Pharma Limited), MIDAZOLAM HYDROCHLORIDE (Gland Pharma Limited), MIDAZOLAM HYDROCHLORIDE (Henry Schein), MIDAZOLAM HYDROCHLORIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), MIDAZOLAM HYDROCHLORIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), MIDAZOLAM HYDROCHLORIDE (Hikma Pharmaceuticals USA), MIDAZOLAM HYDROCHLORIDE (Hospira), MIDAZOLAM HYDROCHLORIDE (Hospira), MIDAZOLAM HYDROCHLORIDE (Hospira), MIDAZOLAM HYDROCHLORIDE (Major Pharmaceuticals), MIDAZOLAM HYDROCHLORIDE (Padagis US LLC), MIDAZOLAM HYDROCHLORIDE (Precision Dose), MIDAZOLAM HYDROCHLORIDE (Precision Dose), MIDAZOLAM IN SODIUM CHLORIDE (Gland Pharma Limited), MIDAZOLAM IN SODIUM CHLORIDE (Hikma Pharmaceuticals USA)
Formula
C18H13ClFN3. HCl
Exact mass
361.0549
Mol weight
362.22
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01835  Benzodiazepine sedative-hypnotics
 DG01567  GABA-A receptor agonist
 DG03199  Antiepileptic agent
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
ATC code: N05CD08
Chemical structure group: DG00920
Product (DG00920): D00550<JP/US> D00696<US>
Efficacy
Anesthetic (intravenous), Sedative-hypnotic
Comment
Benzodiazepines
Target
GABR [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Structure map
map07032  Hypnotics
map07230  GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CD Benzodiazepine derivatives
     N05CD08 Midazolam
      D00696  Midazolam hydrochloride (USAN) <US>
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01835  Benzodiazepine sedative-hypnotics
   DG00920  Midazolam
    D00696  Midazolam hydrochloride
  DG01567  GABA-A receptor agonist
   DG00920  Midazolam
    D00696  Midazolam hydrochloride
  DG03199  Antiepileptic agent
   DG00920  Midazolam
    D00696  Midazolam hydrochloride
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00920  Midazolam
     D00696  Midazolam hydrochloride
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG03199  Antiepileptic agent
   D00696  Midazolam hydrochloride
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D00696  Midazolam hydrochloride (USAN) <US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00696
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00696
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01835  Benzodiazepine sedative-hypnotics
   DG00920  Midazolam
  DG01567  GABA-A receptor agonist
   DG00920  Midazolam
  DG03199  Antiepileptic agent
   DG00920  Midazolam
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00920  Midazolam
Other DBs
CAS: 59467-96-8
PubChem: 7847761
ChEBI: 6932
LigandBox: D00696
NIKKAJI: J300.613A
KCF data

ATOM        24
            1   X   Cl   37.0651  -16.6762
            2   C2y C    32.2059  -17.5222
            3   C8y C    31.3632  -16.4118
            4   C8y C    31.6986  -15.0540
            5   N4y N    32.9606  -14.4754
            6   N2x N    33.6128  -17.4775
            7   C8y C    34.2151  -15.0982
            8   C1x C    34.5018  -16.4679
            9   C8x C    30.6908  -14.0849
            10  C8x C    29.3478  -14.4732
            11  C8y C    29.0123  -15.8311
            12  C8x C    30.0202  -16.7999
            13  X   Cl   27.6465  -16.2258
            14  C8y C    31.5709  -18.7729
            15  C8x C    30.1683  -18.7729
            16  C8x C    29.4677  -19.9863
            17  C8x C    30.1683  -21.1996
            18  C8x C    31.5709  -21.1996
            19  C8y C    32.2715  -19.9863
            20  X   F    33.6834  -19.9864
            21  C8x C    35.1952  -14.0976
            22  N5x N    34.5463  -12.8563
            23  C8y C    33.1652  -13.0899
            24  C1a C    32.1836  -12.1282
BOND        26
            1     4   5 1
            2     2   6 2
            3     5   7 1
            4     3   4 1
            5     6   8 1
            6     2   3 1
            7     7   8 1
            8     4   9 2
            9     9  10 1
            10   10  11 2
            11   11  12 1
            12    3  12 2
            13   11  13 1
            14    2  14 1
            15   14  15 1
            16   15  16 2
            17   16  17 1
            18   17  18 2
            19   18  19 1
            20   14  19 2
            21   19  20 1
            22    7  21 2
            23   21  22 1
            24   22  23 2
            25    5  23 1
            26   23  24 1

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Ontology (6)   
   KEGG BRITE (6)   
Pathway (2)   
   KEGG PATHWAY (2)   
Drug (3)   
   KEGG DGROUP (1)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (4)   
   PubChem (1)   
   ChEBI (1)   
   HSDB (1)   
   NIKKAJI (1)   
Gene (23)   
   KEGG ORTHOLOGY (7)   
   KEGG GENES (16)   
All databases (38)   

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