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KEGG   Homo sapiens (human): 6923
Entry
6923              CDS       T01001                                 
Symbol
ELOB, SIII, TCEB2
Name
(RefSeq) elongin B
  KO
K03873  elongin-B
Organism
hsa  Homo sapiens (human)
Pathway
hsa04066  HIF-1 signaling pathway
hsa04120  Ubiquitin mediated proteolysis
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
hsa05211  Renal cell carcinoma
Network
nt06225  HIF-1 signaling (cancer)
nt06264  Renal cell carcinoma
nt06509  DNA replication
nt06523  Epigenetic regulation by Polycomb complexes
nt06542  HIF signaling
  Element
N00080  Loss of VHL to HIF-1 signaling pathway
N00081  Mutation-inactivated VHL to HIF-1 signaling pathway
N01473  DNA replication termination
N01577  Gene silencing by methylation of H3K27 and ubiquitination of H2AK119
N01872  Proteasomal degradation of HIF by VHL complex
N01873  VHL mutation to HIF-2 signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    6923 (ELOB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    6923 (ELOB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    6923 (ELOB)
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    6923 (ELOB)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    6923 (ELOB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    6923 (ELOB)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    6923 (ELOB)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   Cul2 complex
    Adoptor protein
     6923 (ELOB)
   Cul5 complex
     6923 (ELOB)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   NER (nucleotide excision repair)
    Other NER factors
     6923 (ELOB)
SSDB
Motif
Pfam: ubiquitin Rad60-SLD
Other DBs
NCBI-GeneID: 6923
NCBI-ProteinID: NP_009039
OMIM: 600787
HGNC: 11619
Ensembl: ENSG00000103363
UniProt: Q15370
Structure
Position
16:complement(2771414..2777280)
AA seq 118 aa
MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPDEQRLYKDDQLLDDGKTLGEC
GFTSQTARPQAPATVGLAFRADDTFEALCIEPFSSPPELPDVMKPQDSGSSANEQAVQ
NT seq 357 nt   +upstreamnt  +downstreamnt
atggacgtgttcctcatgatccggcgccacaagaccaccatcttcacggacgccaaggag
tccagcacggtgttcgaactgaagcgcatcgtcgagggcatcctcaagcggcctcctgac
gagcagcggctgtacaaggatgaccaactcttggatgatggcaagacactgggcgagtgt
ggcttcaccagtcaaacagcacggccacaggccccagccacagtggggctggccttccgg
gcagatgacacctttgaggccctgtgcatcgagccgttttccagcccgccagagctgccc
gatgtgatgaagccccaggactcgggaagcagtgccaatgaacaagccgtgcagtga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (5)   
   KEGG PATHWAY (5)   
Network (11)   
   KEGG NETWORK (11)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (34)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (24)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (26)   
   RefSeq(nuc) (2)   
   GenBank (12)   
   EMBL (12)   
3D Structure (168)   
   PDB (168)   
Protein domain (2)   
   Pfam (2)   
All databases (255)   

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