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KEGG   NETWORK: N01872
Entry
N01872                      Network                                
Name
Proteasomal degradation of HIF by VHL complex
Definition
(VHL+RBX1+ELOC+ELOB+CUL2) -| (HIF1A-OH,EPAS1-OH)
  Expanded
(7428+9978+6921+6923+8453) -| (3091,2034)
Class
nt06542 HIF signaling
Type
Reference
Gene
7428  VHL; von Hippel-Lindau tumor suppressor
9978  RBX1; ring-box 1
6921  ELOC; elongin C
6923  ELOB; elongin B
8453  CUL2; cullin 2
3091  HIF1A; hypoxia inducible factor 1 subunit alpha
2034  EPAS1; endothelial PAS domain protein 1
Reference
PMID:35705735
  Authors
Strocchi S, Reggiani F, Gobbi G, Ciarrocchi A, Sancisi V
  Title
The multifaceted role of EGLN family prolyl hydroxylases in cancer: going beyond HIF regulation.
  Journal
Oncogene 41:3665-3679 (2022)
DOI:10.1038/s41388-022-02378-8
Reference
PMID:36630072
  Authors
Choi WW, Boland JL, Kalola A, Lin J
  Title
Belzutifan (MK-6482): Biology and Clinical Development in Solid Tumors.
  Journal
Curr Oncol Rep 25:123-129 (2023)
DOI:10.1007/s11912-022-01354-5

  All links  
Gene (7)   
   KEGG GENES (7)   
Literature (2)   
   PubMed (2)   
All databases (9)   

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