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KEGG   ORTHOLOGY: K22202
Entry
K22202                      KO                                     
Symbol
vpr
Name
HIV virus protein R
Pathway
map03230  Viral genome structure
map03240  Viral replication
map03250  Viral life cycle - HIV-1
map03260  Virion - Human immunodeficiency virus
map05170  Human immunodeficiency virus 1 infection
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06516  TNF signaling
nt06520  CGAS-STING signaling
nt06524  Apoptosis
  Element
N00440  HIV Vpu/Vif/Vpr to cGAS-STING signaling pathway
N00443  HIV Vpr/Nef/Tat to TNF-NFKB signaling pathway
N00447  HIV Vpr/Tat to TNF-JNK signaling pathway
N00453  HIV Vpr to intrinsic apoptotic pathway
N00454  HIV Vpr to intrinsic apoptotic pathway
N00456  HIV Vpr to CDC25-cell cycle G2M
N00457  HIV Vpr to cell cycle G2M
N00458  HIV Vpr to CDC25-cell cycle G2M
N00460  HIV Vpr to WEE1-cell cycle G2M
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03230 Viral genome structure
    K22202  vpr; HIV virus protein R
   03240 Viral replication
    K22202  vpr; HIV virus protein R
   03250 Viral life cycle - HIV-1
    K22202  vpr; HIV virus protein R
   03260 Virion - Human immunodeficiency virus
    K22202  vpr; HIV virus protein R
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K22202  vpr; HIV virus protein R
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K22202  vpr; HIV virus protein R
Viral proteins [BR:ko03200]
 ssRNA-RT viruses
  Human immunodeficiency virus
   K22202  vpr; HIV virus protein R
Other DBs
TC: 1.A.42.1
Genes
VG: 155807(vpr) 1724718(HIV2gp4) 956112(vpr)
Reference
PMID:8552585
  Authors
Piller SC, Ewart GD, Premkumar A, Cox GB, Gage PW
  Title
Vpr protein of human immunodeficiency virus type 1 forms cation-selective channels in planar lipid bilayers.
  Journal
Proc Natl Acad Sci U S A 93:111-5 (1996)
DOI:10.1073/pnas.93.1.111
  Sequence
[vg:155807]
Reference
PMID:27460548
  Authors
Yan Y, Huang F, Yuan T, Sun B, Yang R
  Title
HIV-1 Vpr increases HCV replication through VprBP in cell culture.
  Journal
Virus Res 223:153-60 (2016)
DOI:10.1016/j.virusres.2016.07.007
  Sequence
[vg:155807]

  All links  
Ontology (3)   
   KEGG BRITE (2)   
   TC (1)   
Pathway (10)   
   KEGG PATHWAY (10)   
Network (13)   
   KEGG NETWORK (13)   
Gene (3)   
   KEGG GENES (3)   
Literature (2)   
   PubMed (2)   
All databases (31)   

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KEGG   ORTHOLOGY: K19258
Entry
K19258                      KO                                     
Symbol
tat
Name
HIV protein Tat
Pathway
map03230  Viral genome structure
map03250  Viral life cycle - HIV-1
map03260  Virion - Human immunodeficiency virus
map05170  Human immunodeficiency virus 1 infection
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06516  TNF signaling
nt06517  TLR signaling
nt06524  Apoptosis
  Element
N00436  HIV Tat to TLR2/4-NFKB signaling pathway
N00443  HIV Vpr/Nef/Tat to TNF-NFKB signaling pathway
N00445  HIV Tat/Nef to TNF-p38 signaling pathway
N00447  HIV Vpr/Tat to TNF-JNK signaling pathway
N00448  HIV Tat/Nef to crosstalk between extrinsic and intrinsic apoptotic pathways
N00449  HIV Tat/Nef to crosstalk between extrinsic and intrinsic apoptotic pathways
N00450  HIV Tat to intrinsic apoptotic pathway
N00451  HIV Tat to intrinsic apoptotic pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03230 Viral genome structure
    K19258  tat; HIV protein Tat
   03250 Viral life cycle - HIV-1
    K19258  tat; HIV protein Tat
   03260 Virion - Human immunodeficiency virus
    K19258  tat; HIV protein Tat
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K19258  tat; HIV protein Tat
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   00536 Glycosaminoglycan binding proteins
    K19258  tat; HIV protein Tat
  09185 Viral protein families
   03200 Viral proteins
    K19258  tat; HIV protein Tat
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Microbial pathogens
   K19258  tat; HIV protein Tat
Viral proteins [BR:ko03200]
 ssRNA-RT viruses
  Human immunodeficiency virus
   K19258  tat; HIV protein Tat
Genes
VG: 155871(tat) 1724713(HIV2gp5) 956113(tat)
Reference
PMID:2990041
  Authors
Sodroski J, Patarca R, Rosen C, Wong-Staal F, Haseltine W
  Title
Location of the trans-activating region on the genome of human T-cell lymphotropic virus type III.
  Journal
Science 229:74-7 (1985)
DOI:10.1126/science.2990041
  Sequence
[vg:155871]
Reference
PMID:19812265
  Authors
Romani B, Engelbrecht S, Glashoff RH
  Title
Functions of Tat: the versatile protein of human immunodeficiency virus type 1.
  Journal
J Gen Virol 91:1-12 (2010)
DOI:10.1099/vir.0.016303-0

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (8)   
   KEGG PATHWAY (8)   
Network (12)   
   KEGG NETWORK (12)   
Gene (3)   
   KEGG GENES (3)   
Literature (2)   
   PubMed (2)   
All databases (28)   

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