KEGG NETWORK: N00456

NETWORK: N00456

Entry

N00456                      Network

Name

HIV Vpr to CDC25-cell cycle G2M

Definition

Vpr == (DCAF1+DDB1+CUL4) -> ATR -> CHEK1 -| CDC25C -> (CCNB+CDK1)

Expanded

K22202 == (9730+1642+(8451,8450)) -> 545 -> 1111 -| 995 -> ((891,9133,85417)+983)

Class

nt06161 Human immunodeficiency virus 1 (HIV-1)

Type

Pathogen

Pathway

hsa05170

Human immunodeficiency virus 1 infection

Disease

H01563

HIV infection

Gene

9730	DCAF1; DDB1 and CUL4 associated factor 1

1642	DDB1; damage specific DNA binding protein 1

8451	CUL4A; cullin 4A

8450	CUL4B; cullin 4B

545	ATR; ATR serine/threonine kinase

1111	CHEK1; checkpoint kinase 1

995	CDC25C; cell division cycle 25C

891	CCNB1; cyclin B1

9133	CCNB2; cyclin B2

85417

CCNB3; cyclin B3

983	CDK1; cyclin dependent kinase 1

Perturbant

K22202 (Vpr)

vpr; HIV-1 virus protein R

Reference

PMID:18514189

Authors

Andersen JL, Le Rouzic E, Planelles V

Title

HIV-1 Vpr: mechanisms of G2 arrest and apoptosis.

Journal

Exp Mol Pathol 85:2-10 (2008)
DOI:10.1016/j.yexmp.2008.03.015

Reference

PMID:24795708

Authors

Bregnard C, Benkirane M, Laguette N

Title

DNA damage repair machinery and HIV escape from innate immune sensing.

Journal

Front Microbiol 5:176 (2014)
DOI:10.3389/fmicb.2014.00176

Reference

PMID:17559673

Authors

DeHart JL, Zimmerman ES, Ardon O, Monteiro-Filho CM, Arganaraz ER, Planelles V

Title

HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system.

Journal

Virol J 4:57 (2007)
DOI:10.1186/1743-422X-4-57

Reference

PMID:17626091

Authors

Tan L, Ehrlich E, Yu XF

Title

DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest.

Journal

J Virol 81:10822-30 (2007)
DOI:10.1128/JVI.01380-07

All links

Pathway (1)   
   KEGG PATHWAY (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (11)   
Literature (4)   
   PubMed (4)   
All databases (17)   

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