KEGG ORTHOLOGY: K15604

ORTHOLOGY: K15604

Entry

K15604                      KO

Symbol

LYL1

Name

protein lyl-1

Pathway

map05202

Transcriptional misregulation in cancer

Disease

H00002

T-cell acute lymphoblastic leukemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K15604  LYL1; protein lyl-1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K15604  LYL1; protein lyl-1
Transcription factors [BR:ko03000]
Eukaryotic type
  Basic helix-loop-helix (bHLH)
   Tal/Twist/Atonal/Hen, Lymphoid factors
    K15604  LYL1; protein lyl-1

Genes

HSA:	4066(LYL1)

PTR:	468743(LYL1)

PPS:	100971215(LYL1)

GGO:	101150955(LYL1)

PON:	100454772(LYL1)

PPYG:

129020188(LYL1)

NLE:	100603021(LYL1)

HMH:	116478564(LYL1)

SSYN:

129459243(LYL1)

MCC:	718185(LYL1)

MCF:	102126352(LYL1)

MTHB:

126942740

MNI:	105464720(LYL1)

CSAB:

103234008(LYL1)

CATY:

105601552(LYL1)

PANU:

101010460(LYL1)

TGE:	112612809(LYL1)

MLEU:

105550053(LYL1)

RRO:	104661143(LYL1)

RBB:	108544106(LYL1)

TFN:	117075618(LYL1)

PTEH:

111523800(LYL1)

CANG:

105520925(LYL1)

CJC:	100389522(LYL1)

SBQ:	101042244(LYL1)

CIMI:

108281967(LYL1)

ANAN:

105706010(LYL1)

CSYR:

103256850(LYL1)

MMUR:

105885505(LYL1)

LCAT:

123637343(LYL1)

PCOQ:

105807869(LYL1)

OGA:	100952445(LYL1)

MMU:	17095(Lyl1)

MCAL:

110299580(Lyl1)

MPAH:

110337648(Lyl1)

RNO:	304663(Lyl1)

MCOC:

116069723(Lyl1)

ANU:	117723280(Lyl1)

ASYL:

127672023(Lyl1)

MUN:	110545833(Lyl1)

CGE:	100757879(Lyl1)

MAUA:

101832864(Lyl1)

PROB:

127229896(Lyl1)

PLEU:

114687097(Lyl1)

MORG:

121446779(Lyl1)

MFOT:

126487795

AAMP:

119801843(Lyl1)

NGI:	103751869(Lyl1)

HGL:	101721619(Lyl1)

CPOC:

100726829(Lyl1)

CCAN:

109681288(Lyl1)

DORD:

105999225(Lyl1)

DSP:	122100262(Lyl1)

PLOP:

125348834(Lyl1)

NCAR:

124969181

MMMA:

107145252(Lyl1)

ITI:	101964696(Lyl1)

OCU:

127488846

OPI:	101517599(LYL1)

TUP:	102472635(LYL1)

GVR:	103595815(LYL1)

CFA:	119870325 610908(LYL1)

CLUD:

112666596(LYL1) 112675511

VVP:	112908113(LYL1)

VLG:	121484960 121494561(LYL1)

NPO:	129521287(LYL1)

AML:	100473448(LYL1)

UMR:	103682194(LYL1)

UAH:	113247212(LYL1)

UAR:	123777699(LYL1)

ELK:

111162405

LLV:

125083935

MPUF:

101672301(LYL1)

MNP:	132011049(LYL1)

MLK:	131823602(LYL1)

NVS:	122909671(LYL1)

ORO:	101376425(LYL1)

EJU:	114197774(LYL1)

ZCA:	113916916(LYL1)

MLX:	118005779(LYL1)

NSU:	110593747(LYL1)

LWW:	102748030(LYL1)

FCA:	101094082(LYL1)

PYU:	121014061(LYL1)

PCOO:

112852569(LYL1)

PBG:	122486953(LYL1)

PVIV:

125148436(LYL1)

LRUF:

124525114

PPAD:

109254021(LYL1)

PUC:

125929057

AJU:

106986083

HHV:	120245290(LYL1)

BTA:	615458(LYL1)

BOM:	102277320(LYL1)

BIU:	109561524(LYL1)

BBUB:

123466186(LYL1)

BBIS:

104999900(LYL1)

CHX:	102168994(LYL1)

OAS:	101121935(LYL1)

BTAX:

128051554(LYL1)

CSUM:

138085986(LYL1)

ODA:	120864049(LYL1)

CCAD:

122440520(LYL1)

MREE:

136155670(LYL1)

MBEZ:

129559484(LYL1)

SSC:	100523949(LYL1)

CFR:	106728520(LYL1)

CBAI:

105068403(LYL1)

CDK:

105100762

VPC:	102539101(LYL1)

BACU:

103008315(LYL1)

BMUS:

118892055(LYL1)

LVE:	103080549(LYL1)

OOR:	101277851(LYL1)

DLE:	111166768(LYL1)

PCAD:

102977592(LYL1)

PSIU:

116750597(LYL1)

NASI:

112414730(LYL1)

ECB:	111774278(LYL1)

EPZ:	103567239(LYL1)

EAI:	106844290(LYL1)

MYB:	102257572(LYL1)

MYD:	102758942(LYL1)

MMYO:

118652661(LYL1)

MLF:	102441798(LYL1)

MDT:	132234934(LYL1)

PKL:	118710354(LYL1)

EFUS:

103301002(LYL1)

MNA:	107541512(LYL1)

DRO:	112301445(LYL1)

SHON:

118984111(LYL1)

AJM:	119049670(LYL1)

PDIC:

114503280(LYL1)

PHAS:

123828188(LYL1)

MMF:	118615972(LYL1)

PPAM:

129062537(LYL1)

HAI:	109394287(LYL1)

RFQ:	117037594(LYL1)

PALE:

102882828(LYL1)

PGIG:

120618515(LYL1)

PVP:	105307180(LYL1)

RAY:	107519395(LYL1)

MJV:	108399679(LYL1)

TOD:	119241014(LYL1)

SARA:

101537858(LYL1)

SFUM:

130028739(LYL1)

SETR:

126030258(LYL1)

LAV:	100677282(LYL1)

TMU:

101341883

ETF:	101655944(LYL1)

DNM:	101434227(LYL1)

MDO:	100027334(LYL1)

GAS:	123232093(LYL1)

SHR:	100925761(LYL1)

AFZ:

127544811

PCW:	110214253(LYL1)

TVP:	118846589(LYL1)

PBRV:

138157406(LYL1)

OAA:	100079450(LYL1)

AMJ:	102558472(LYL1)

CMY:	119564803(LYL1)

CCAY:

125627589(LYL1)

DCC:	119846067(LYL1)

CABI:

116830828(LYL1)

MRV:	120391233(LYL1)

ACS:	100551590(lyl1)

ASAO:

132768026(LYL1)

PVT:	110077960(LYL1)

SUND:

121924136(LYL1)

PBI:	103057899(LYL1)

PMUR:

107285148(LYL1)

CTIG:

120309874(LYL1)

PGUT:

117675632(LYL1)

APRI:

131190890(LYL1)

PTEX:

113446896(LYL1)

NSS:	113419958(LYL1)

VKO:	123030149(LYL1)

PMUA:

114587809(LYL1)

PRAF:

128404897(LYL1)

ZVI:	118075424(LYL1)

HCG:	128348268(LYL1)

GJA:

107116222

EMC:	129346566(LYL1)

XLA:

108705239

XTR:	100486490(lyl1)

NPR:

108799128

MUO:	115464320(LYL1)

GSH:	117350062(LYL1)

DRE:	100333113(lyl1)

SRX:	107705884 107737997

SANH:

107666684 107676716

SGH:	107568389 107572350

CCAR:

109069366 109069951

CAUA:

113095139

CGIB:

128015316

PTET:

122333340(lyl1)

LROH:

127166805(lyl1)

OMC:	131541928(lyl1)

PPRM:

120467937(lyl1)

MAMB:

125274456(lyl1)

CIDE:

127513838

CERY:

137011601(lyl1)

MASI:

127445934

TROS:

130557390(lyl1)

TDW:	130425210(lyl1)

MANU:

129451141(lyl1)

IPU:	108273269(lyl1)

IFU:	128615941(lyl1)

PHYP:

113538303

SMEO:

124388946(lyl1)

TFD:	113634494(lyl1)

TVC:	132844881(lyl1)

TRN:	134316537(lyl1)

AMEX:

103047713(lyl1)

CMAO:

118807900(lyl1)

EEE:

113579501

CHAR:

105910150

TRU:

101073920

TFS:	130527261(lyl1)

TNG:	GSTEN00011622G001

NCC:

104950506

TBEN:

117482278(lyl1)

CGOB:

115012471

PGEO:

117446261(lyl1)

GACU:

117537992(lyl1)

EMAC:

134864329(lyl1)

ELY:	117255854(lyl1)

EFO:	125886047(lyl1)

PLEP:

121942249(lyl1)

SLUC:

116040481(lyl1)

ECRA:

117936787(lyl1)

ESP:

116702853

PFLV:

114563295

GAT:	120825068(lyl1)

PPUG:

119218428(lyl1)

AFB:	129096465(lyl1)

CLUM:

117734032(lyl1)

PSWI:

130190627(lyl1)

CANA:

137794917(lyl1)

CVE:	137885266(lyl1)

MSAM:

119899202(lyl1)

SCHU:

122873632(lyl1)

CUD:	121507724(lyl1)

SPUL:

138594718(lyl1)

ALAT:

119004490(lyl1)

ASTR:

137600703(lyl1)

MZE:

101471525

ONL:

100700016

OAU:	116321386(lyl1)

OLA:

101175459

OML:	112157311(lyl1)

CSAI:

133451356(lyl1)

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122829999(lyl1)

CVG:

107095687

CTUL:

119788226(lyl1)

GMU:	124869081(lyl1)

NFU:

107382237

KMR:	108244322(lyl1)

ALIM:

106523991

NWH:	119430446(lyl1)

AOCE:

111584777

EJA:	138209394(lyl1)

BFRE:

138620248(lyl1)

MCEP:

125004758(lyl1)

CSEM:

103384168

POV:

109627291

SSEN:

122770528(lyl1)

HHIP:

117771664(lyl1)

HSP:	118100202(lyl1)

PPLT:

128433717(lyl1)

SMAU:

118312823(lyl1)

LCF:	108875827(lyl1)

SDU:

111237690

SLAL:

111664576

XGL:	120800115(lyl1)

HCQ:

109511093

SSCV:

125969228(lyl1)

SBIA:

133505654(lyl1)

PEE:	133404522(lyl1)

PTAO:

133477125(lyl1)

BPEC:

110172613

MALB:

109958490

BSPL:

114860704(lyl1)

SJO:	128368175(lyl1)

SSCO:

133990822(lyl1)

SASA:

106590038 106590324

STRU:

115147361 115178081

OTW:	112247973(lyl1)

OMY:	110485522(lyl1) 118938211

OGO:	124015989(lyl1)

ONE:

115125845

OKI:

109876406

OKE:	118375210 127922542

SNH:	120032644(lyl1)

CCLU:

121553957(lyl1)

ELS:

105012148

SFM:

108939887

PKI:

111833551

AANG:

118220783(lyl1)

CCOG:

133121780(lyl1)

LOC:

102686949

PSPA:

121309147(lyl1)

ARUT:

117401980(lyl1) 117965654

PSEX:

120541224(lyl1)

LCM:	102353972(LYL1)

RTP:

CPLA:

HOC:

LERI:

PMRN:

LRJ:

SPU:	115925133 587670

LPIC:

APLC:

HRF:

HASI:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

XEN:

Reference

PMID:2752424

Authors

Mellentin JD, Smith SD, Cleary ML

Title

lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif.

Journal

Cell 58:77-83 (1989)
DOI:10.1016/0092-8674(89)90404-2

Sequence

[hsa:4066]

Reference

PMID:11350595

Authors

Ghosh I, Bishop P, Chmielewski J

Title

DNA binding properties of basic helix-loop-helix fusion proteins of Tal and E47.

Journal

J Pept Res 57:354-60 (2001)
DOI:10.1034/j.1399-3011.2001.00846.x

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   KEGG DISEASE (1)   
Gene (379)   
   KEGG GENES (341)   
   KEGG MGENES (19)   
   RefGene (16)   
   OC (3)   
Literature (2)   
   PubMed (2)   
All databases (386)   

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