KEGG DISEASE: T-cell acute lymphoblastic leukemia

DISEASE: T-cell acute lymphoblastic leukemia

Entry

H00002                      Disease

Name

T-cell acute lymphoblastic leukemia;
T-cell acute lymphocytic leukemia

Subgroup

T-cell lymphoblastic lymphoma

Description

Acute lymphocytic leukemia (ALL) is a clonal stem cell malignancy of excessive lymphoblast proliferation. It is now understood that ALL and lymphoblastic lymphoma are the same disease entities at the morphologic and immunophenotypic levels and classified as either B- and T-cell lymphoblastic leukemia/lymphoma (B-ALL and T-ALL). T-ALL comprises 15% of paediatric and 25% of adult ALL cases. T cell transformation is a multi-step process in which different genetic alterations cooperate to alter the normal mechanisms that control cell growth, proliferation, survival, and differentiation during thymocyte development. In this context, constitutive activation of NOTCH1 signaling is the most prominent oncogenic pathway in T cell transformation. In addition, T-ALLs characteristically show the translocation and aberrant expression of transcription factor oncogenes. These oncogenic transcription factors include T-cell leukaemia homeobox protein 1 (TLX1 also known as HOX11), TLX3 (HOX11L2), LYL1, TAL1 and MLL.

Category

Cancer

Brite

Human diseases in ICD-11 classification [BR:br08403]
02 Neoplasms
  Neoplasms of haematopoietic or lymphoid tissues
   Precursor lymphoid neoplasms
    2A71  Precursor T-lymphoblastic neoplasms
     H00002  T-cell acute lymphoblastic leukemia
Tumor markers [br08442.html]
H00002

Gene

NOTCH1 (mutation) [HSA:4851] [KO:K02599]
TAL1 (overexpression) [HSA:6886] [KO:K09068]
TAL2 [HSA:6887] [KO:K09068]
LYL1 (expression) [HSA:4066] [KO:K15604]
MLL-ENL (translocation) [HSA:4297] [KO:K09186]
HOX11 (translocation) [HSA:3195] [KO:K09340]
MYC (translocation) [HSA:4609] [KO:K04377]
LMO2 (translocation) [HSA:4005] [KO:K15612]
HOX11L2 (translocation) [HSA:30012] [KO:K15607]
PICALM-MLLT10 (translocation) [HSA:8028] [KO:K23588]

Drug

Cyclophosphamide [DR:D00287]
Methotrexate [DR:D00142]
Mercaptopurine [DR:D00161]
Clofarabine [DR:D03546]
Nelarabine [DR:D05134]
Vincristine sulfate [DR:D02197] (Philadelphia chromosome-negative)
Teniposide [DR:D02698]
Doxorubicin hydrochloride [DR:D01275]
Daunorubicin hydrochloride [DR:D01264]
Mitoxantrone hydrochloride [DR:D02166]
Pemigatinib [DR:D11417] (FGFR1 rearrangement)
Brexucabtagene autoleucel [DR:D11880]
Asparaginase [DR:D02997]
Pegaspargase [DR:D05387]
Calaspargase pegol [DR:D10096]
Enocitabine [DR:D01633]
Revumenib citrate [DR:D12729] (with a KMT2A translocation)

Other DBs

ICD-11:

2A71

ICD-10:

C83.5 C91.0

MeSH:

D054218

Reference

PMID:25781572

Authors

Roberts KG, Mullighan CG

Title

Genomics in acute lymphoblastic leukaemia: insights and treatment implications.

Journal

Nat Rev Clin Oncol 12:344-57 (2015)
DOI:10.1038/nrclinonc.2015.38

Reference

PMID:18783329

Authors

Teitell MA, Pandolfi PP

Title

Molecular genetics of acute lymphoblastic leukemia.

Journal

Annu Rev Pathol 4:175-98 (2009)
DOI:10.1146/annurev.pathol.4.110807.092227

Reference

PMID:23023710

Authors

Van Vlierberghe P, Ferrando A

Title

The molecular basis of T cell acute lymphoblastic leukemia.

Journal

J Clin Invest 122:3398-406 (2012)
DOI:10.1172/JCI61269

Reference

PMID:22449370

Authors

Cornell RF, Palmer J

Title

Adult acute leukemia.

Journal

Dis Mon 58:219-38 (2012)
DOI:10.1016/j.disamonth.2012.01.011

Reference

PMID:22145858

Authors

Kraszewska MD, Dawidowska M, Szczepanski T, Witt M

Title

T-cell acute lymphoblastic leukaemia: recent molecular biology findings.

Journal

Br J Haematol 156:303-15 (2012)
DOI:10.1111/j.1365-2141.2011.08957.x

Reference

PMID:27069254

Authors

Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM, Bloomfield CD, Cazzola M, Vardiman JW

Title

The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia.

Journal

Blood 127:2391-405 (2016)
DOI:10.1182/blood-2016-03-643544

Reference

PMID:12556326

Authors

Harrison JD, Muirhead CR.

Title

Quantitative comparisons of cancer induction in humans by internally deposited radionuclides and external radiation.

Journal

Int J Radiat Biol 79:1-13 (2003)
DOI:10.1080/0955300021000038671

Reference

PMID:1763056

Authors

Xia Y, Brown L, Yang CY, Tsan JT, Siciliano MJ, Espinosa R 3rd, Le Beau MM, Baer RJ

Title

TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia.

Journal

Proc Natl Acad Sci U S A 88:11416-20 (1991)
DOI:10.1073/pnas.88.24.11416

» Japanese version

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Ontology (1)   
   KEGG BRITE (1)   
Network (4)   
   KEGG VARIANT (4)   
Drug (42)   
   KEGG DRUG (42)   
Gene (19)   
   KEGG ORTHOLOGY (9)   
   KEGG GENES (10)   
Literature (8)   
   PubMed (8)   
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