KEGG ORTHOLOGY: K04359

ORTHOLOGY: K04359

Entry

K04359                      KO

Symbol

PDGFA

Name

platelet-derived growth factor subunit A

Pathway

map01521

EGFR tyrosine kinase inhibitor resistance

map04010

MAPK signaling pathway

map04014

Ras signaling pathway

map04015

Rap1 signaling pathway

map04020

Calcium signaling pathway

map04072

Phospholipase D signaling pathway

map04151

PI3K-Akt signaling pathway

map04510

Focal adhesion

map04540

Gap junction

map04630

JAK-STAT signaling pathway

map04810

Regulation of actin cytoskeleton

map05200

Pathways in cancer

map05202

Transcriptional misregulation in cancer

map05206

MicroRNAs in cancer

map05214

Glioma

map05215

Prostate cancer

map05218

Melanoma

map05231

Choline metabolism in cancer

map05418

Fluid shear stress and atherosclerosis

Disease

H00015

Malignant pleural mesothelioma

H00042

Glioma

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04014 Ras signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04015 Rap1 signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04630 JAK-STAT signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04020 Calcium signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04072 Phospholipase D signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
   04151 PI3K-Akt signaling pathway
    K04359  PDGFA; platelet-derived growth factor subunit A
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04359  PDGFA; platelet-derived growth factor subunit A
   04540 Gap junction
    K04359  PDGFA; platelet-derived growth factor subunit A
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04359  PDGFA; platelet-derived growth factor subunit A
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
   05202 Transcriptional misregulation in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
   05206 MicroRNAs in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
   05231 Choline metabolism in cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
  09162 Cancer: specific types
   05214 Glioma
    K04359  PDGFA; platelet-derived growth factor subunit A
   05218 Melanoma
    K04359  PDGFA; platelet-derived growth factor subunit A
   05215 Prostate cancer
    K04359  PDGFA; platelet-derived growth factor subunit A
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K04359  PDGFA; platelet-derived growth factor subunit A
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K04359  PDGFA; platelet-derived growth factor subunit A
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K04359  PDGFA; platelet-derived growth factor subunit A
   00536 Glycosaminoglycan binding proteins
    K04359  PDGFA; platelet-derived growth factor subunit A
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Growth factors (RTK binding)
   K04359  PDGFA; platelet-derived growth factor subunit A
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Growth factors/receptors
   K04359  PDGFA; platelet-derived growth factor subunit A

Other DBs

GO:

0005161

Genes

HSA:	5154(PDGFA)

PTR:	740202(PDGFA)

PPS:	100991389(PDGFA)

GGO:	101132059(PDGFA)

PON:	100440212(PDGFA)

PPYG:

129040960(PDGFA)

NLE:	100583683(PDGFA)

HMH:	116462932(PDGFA)

SSYN:

129471850(PDGFA)

MCC:	707725(PDGFA)

MCF:	102126620(PDGFA)

MTHB:

126950578

MNI:	105483431(PDGFA)

CSAB:

103246906(PDGFA)

CATY:

105571784(PDGFA)

PANU:

100998521(PDGFA)

TGE:	112620011(PDGFA)

MLEU:

105537884(PDGFA)

RRO:	104664975(PDGFA)

RBB:	108542315(PDGFA)

TFN:	117072614(PDGFA)

PTEH:

111523727(PDGFA)

CANG:

105522469(PDGFA)

CJC:	100412906(PDGFA)

SBQ:	101034511(PDGFA)

CIMI:

108289011(PDGFA)

ANAN:

135275177(PDGFA)

CSYR:

103255351(PDGFA)

MMUR:

105868355(PDGFA)

LCAT:

123632534(PDGFA)

PCOQ:

105806045(PDGFA)

OGA:	100944643(PDGFA)

MMU:	18590(Pdgfa)

MCAL:

110294651(Pdgfa)

MPAH:

110312881(Pdgfa)

RNO:	25266(Pdgfa)

MCOC:

116068639(Pdgfa)

ANU:	117698163(Pdgfa)

ASYL:

127672774(Pdgfa)

MUN:	110550699(Pdgfa)

CGE:	100771503(Pdgfa)

MAUA:

101832477(Pdgfa)

PROB:

127237325(Pdgfa)

PLEU:

114682214(Pdgfa)

MORG:

121446311(Pdgfa)

MFOT:

126514366

AAMP:

119825753(Pdgfa)

NGI:	103748699(Pdgfa)

HGL:	101725739(Pdgfa)

CCAN:

109684500(Pdgfa)

DORD:

105990925(Pdgfa)

DSP:	122113621(Pdgfa)

PLOP:

125339510(Pdgfa)

NCAR:

124970285

MMMA:

107155905(Pdgfa)

ITI:	101963872(Pdgfa)

OCU:

100352388

TUP:	102499235(PDGFA)

GVR:	103595105(PDGFA)

CFA:	491597(PDGFA)

CLUD:

112640154(PDGFA)

VVP:	112929281(PDGFA)

VLG:	121487555(PDGFA)

NPO:	129519919(PDGFA)

AML:	100473486(PDGFA)

UMR:	103670054(PDGFA)

UAR:	123802515(PDGFA)

ELK:

111145884

LLV:

125090848

MPUF:

101684232(PDGFA)

MNP:	132026405(PDGFA)

MLK:	131819467(PDGFA)

NVS:	122895287(PDGFA)

ORO:	101386160(PDGFA)

ZCA:	113933137(PDGFA)

MLX:	117999262(PDGFA)

NSU:	110571958(PDGFA)

LWW:	102739254(PDGFA)

FCA:	101087287(PDGFA)

PYU:	121017467(PDGFA)

PBG:	122471191(PDGFA)

PVIV:

125154510(PDGFA)

LRUF:

124519341

PPAD:

109251089(PDGFA)

PUC:

125928362

AJU:

106966514

HHV:	120227991(PDGFA)

BTA:	505908(PDGFA)

BOM:	102271219(PDGFA)

BIU:	109578611(PDGFA)

BBIS:

104987448(PDGFA)

CHX:	102174268(PDGFA)

OAS:	114110564(PDGFA)

BTAX:

128065733(PDGFA)

CSUM:

138076081(PDGFA)

ODA:	120882986(PDGFA)

CCAD:

122433132(PDGFA)

MREE:

136160241(PDGFA)

MBEZ:

129545815(PDGFA)

SSC:	100519764(PDGFA)

CFR:	102520052(PDGFA)

CBAI:

105077813(PDGFA)

CDK:	105102061(PDGFA)

VPC:	102532201(PDGFA)

BACU:

103005337(PDGFA)

BMUS:

118881469(PDGFA)

LVE:	103089216(PDGFA)

OOR:	101287211(PDGFA)

DLE:	111169371(PDGFA)

PCAD:

102989848(PDGFA)

PSIU:

116740378(PDGFA)

NASI:

112412068(PDGFA)

ECB:	100055086(PDGFA)

EPZ:	103555992(PDGFA)

EAI:	106834748(PDGFA)

MYB:	102253551(PDGFA)

MYD:	102762551(PDGFA)

MMYO:

118658213(PDGFA)

MLF:	102422469(PDGFA)

MDT:	132236071(PDGFA)

PKL:	118715966(PDGFA)

EFUS:

103299170(PDGFA)

MNA:	107543141(PDGFA)

DRO:	112319719(PDGFA)

SHON:

118995064(PDGFA)

AJM:	119043762(PDGFA)

PDIC:

114510403(PDGFA)

PHAS:

123810721(PDGFA)

MMF:	118615652(PDGFA)

PPAM:

129065324(PDGFA)

HAI:	109380137(PDGFA)

RFQ:	117016876(PDGFA)

PALE:

102893670(PDGFA)

PGIG:

120615920(PDGFA)

PVP:	105294593(PDGFA)

RAY:	107497394(PDGFA)

MJV:	118970652(PDGFA)

TOD:	119241452(PDGFA)

SARA:

101545086(PDGFA)

SFUM:

130036457(PDGFA)

SETR:

126030482(PDGFA)

TMU:

101344666

ETF:	101657212(PDGFA)

DNM:	101420455(PDGFA)

MDO:	100020951(PDGFA)

GAS:	123234190(PDGFA)

SHR:	100924985(PDGFA) 116422035

AFZ:

127564197

PCW:	110201572(PDGFA)

TVP:	118834675(PDGFA)

PBRV:

138158718(PDGFA)

OAA:	100081033(PDGFA)

GGA:	374196(PDGFA)

PCOC:

116237353(PDGFA)

MGP:	100545955(PDGFA)

CJO:	107320713(PDGFA)

TPAI:

128079041(PDGFA)

LMUT:

125700597(PDGFA)

NMEL:

110405632(PDGFA)

APLA:

101803502(PDGFA)

ACYG:

106033384(PDGFA)

CATA:

118249111(PDGFA)

AFUL:

116495257(PDGFA)

TGU:	100222155(PDGFA)

LSR:	110475507(PDGFA)

SCAN:

103817870(PDGFA)

PMOA:

120513085(PDGFA)

OTC:	121334533(PDGFA)

PRUF:

121350738(PDGFA)

GFR:	102032936(PDGFA)

FAB:	101810376(PDGFA)

OMA:	130259168(PDGFA)

PHI:	102099148(PDGFA)

PMAJ:

107211209(PDGFA)

CCAE:

111936274(PDGFA)

CCW:	104685042(PDGFA)

CBRC:

103615596(PDGFA)

ACOE:

138118912(PDGFA)

ETL:	114054750(PDGFA)

ZAB:	102075181(PDGFA)

ZLE:	135454389(PDGFA)

ACHL:

103808525(PDGFA)

SVG:	106849274(PDGFA)

MMEA:

130583111(PDGFA)

HRT:	120759459(PDGFA)

SATI:

136367877(PDGFA)

FPG:	101922505(PDGFA)

FCH:	102059520(PDGFA)

CCRI:

104163324(PDGFA)

NNT:	104401729(PDGFA)

SHAB:

115606513(PDGFA)

ACUN:

113485656(PDGFA)

TALA:

104356513(PDGFA)

ACHC:

115335808(PDGFA)

HALD:

104311822(PDGFA)

HLE:	104833534(PDGFA)

AGEN:

126034072

HHAR:

128134821(PDGFA)

GCL:

127022335

CSTI:

104550608(PDGFA)

LDI:	104341533(PDGFA)

MNB:	103772210(PDGFA)

DPUB:

104307709(PDGFA)

PPUS:

135180893(PDGFA)

AVIT:

104269103(PDGFA)

BRHI:

104499817

EGZ:	104128975(PDGFA)

NNI:	104015206(PDGFA)

PCRI:

104025397(PDGFA)

PCAO:

104048151

PADL:

103913559(PDGFA)

AFOR:

103904978(PDGFA)

FGA:	104071632(PDGFA)

GSTE:

104251875(PDGFA)

CLV:	102085857(PDGFA)

MUI:	104548409(PDGFA)

PGUU:

104463181(PDGFA)

PLET:

104615870(PDGFA)

EHS:	104515753(PDGFA)

CMAC:

104477662

CUCA:

104066003(PDGFA)

TEO:	104373725(PDGFA)

BREG:

104631307(PDGFA)

OHA:	104329111(PDGFA)

ACAR:

104521094(PDGFA)

CPEA:

104393744(PDGFA)

CVF:	104287451(PDGFA)

RTD:	128913970(PDGFA)

AROW:

112974232(PDGFA)

NPD:	112959759(PDGFA)

TGT:	104577799(PDGFA)

DNE:	112992914(PDGFA)

SCAM:

104153975(PDGFA)

ASN:	102386051(PDGFA)

AMJ:	102568490(PDGFA)

CPOO:

109314821(PDGFA)

GGN:	109294307(PDGFA)

PSS:	102453111(PDGFA)

CMY:	102936738(PDGFA)

CCAY:

125643930(PDGFA)

DCC:	119863047(PDGFA)

CPIC:

101940087(PDGFA)

TST:	117883612(PDGFA)

CABI:

116819340(PDGFA)

MRV:	120373866(PDGFA)

ACS:	100560004(pdgfa)

ASAO:

132780030(PDGFA)

PVT:	110090337(PDGFA)

SUND:

121914929(PDGFA)

PBI:	103066198(PDGFA)

PMUR:

107291891(PDGFA)

CTIG:

120315695(PDGFA)

PGUT:

117673284(PDGFA)

APRI:

131185124(PDGFA)

PTEX:

113438773(PDGFA)

NSS:	113423617(PDGFA)

VKO:	123025095(PDGFA)

PMUA:

114584301(PDGFA)

PRAF:

128401314(PDGFA)

ZVI:	118092483(PDGFA)

HCG:	128336685(PDGFA)

GJA:	107115509(PDGFA)

STOW:

125431785(PDGFA)

EMC:	129340503(PDGFA)

XLA:	108701573(pdgfa.L) 397765(pdgfa.S)

XTR:	100038202(pdgfa)

NPR:	108800714(PDGFA)

RTEM:

120943462(PDGFA)

BBUF:

121008336(PDGFA)

BGAR:

122938815(PDGFA)

MUO:	115475965(PDGFA)

GSH:	117345768(PDGFA)

DRE:	137487188 378480(pdgfaa) 767790(pdgfab) 796490(pdgfbb)

SRX:	107710051 107715705 107716439 107718638 107740670 107753752

SANH:

107653445 107655387 107656789 107659307 107661852 107662372

SGH:	107563229 107565186 107565608 107569132(pdgfa) 107582898 107585031

CCAR:

109046752 109046975 109060204 109077293 109078389 109109212

CAUA:

113039942 113046740 113047958 113050994 113065132 113067655

CGIB:

127942589 127946206 127952842 127953549 127953918 127988409

PTET:

122328185 122341462(pdgfab) 122341906(pdgfbb)

LROH:

127153154(pdgfaa) 127162991(pdgfbb) 127163317(pdgfab)

OMC:	131530560(pdgfaa) 131536183(pdgfbb) 131538005(pdgfab)

PPRM:

120473118(pdgfab) 120489992(pdgfbb) 120495257

RKG:	130069207(pdgfab) 130101075(pdgfbb) 130103468

MAMB:

125263758 125266909(pdgfab) 125273321(pdgfbb)

CIDE:

127508464 127509581 127520426

CERY:

137017385(pdgfbb) 137017882(pdgfab) 137029200(pdgfaa)

MASI:

127438286 127438857 127449997 127450278 127451399 127451886

TROS:

130548738 130562289(pdgfab) 130562299(pdgfbb)

TDW:	130425514(pdgfbb) 130426907(pdgfab) 130429407(pdgfaa)

MANU:

129436444(pdgfbb) 129436577(pdgfab) 129453754(pdgfaa)

IPU:	108259440 108260470(pdgfbb)

IFU:	128600808(pdgfbb) 128603042

PHYP:

113528535 113547595

SMEO:

124380081(pdgfaa) 124396930(pdgfbb)

TFD:	113638132(pdgfbb) 113657065

TVC:	132838686 132861009(pdgfbb)

TRN:

134304197

AMEX:

103022197 103031683(pdgfab) 103032641(pdgfbb)

CMAO:

118801273(pdgfab) 118804610

EEE:	113576794(pdgfa) 113581484

CHAR:

105897421 105905811 122133303

TRU:	101063539 101077475(pdgfa)

TFS:	130515028(pdgfab) 130526903

TNG:	GSTEN00033366G001 GSTEN00034853G001

LCO:	104925707(pdgfa) 104938193

NCC:	104945697(pdgfa)

TBEN:

117484386 117492572(pdgfab)

CGOB:

115006184 115012768

PGEO:

117451375(pdgfab)

GACU:

117548665(pdgfab)

EMAC:

134862786 134878479(pdgfab)

ELY:	117255028 117268594(pdgfab)

EFO:	125879703(pdgfab) 125885505

PLEP:

121942499 121957233(pdgfab)

SLUC:

116042707 116059555(pdgfab)

ECRA:

117957643(pdgfab) 117961247

ESP:	116700400 116703151(pdgfa)

PFLV:

114564713 114570050(pdgfa)

GAT:	120828147(pdgfab)

PPUG:

119220851(pdgfab)

AFB:	129098582(pdgfab)

CLUM:

117735148(pdgfab)

PSWI:

130188983(pdgfab)

CANA:

137787198(pdgfab)

CVE:	137866661 137878319(pdgfab)

MSAM:

119889692(pdgfab) 119898647

SCHU:

122868816(pdgfab) 122871829

CUD:	121503987(pdgfab) 121508825

SPUL:

138594958 138602710(pdgfab)

ALAT:

119014493 119021530

ASTR:

137600216 137609935(pdgfab)

MZE:	101486813(pdgfa) 101486854 112432818

ONL:	100690958 100702821(pdgfa)

OAU:	116312442 116321448(pdgfab)

OLA:	101156252(pdgfa) 101171139

OML:	112137135 112147005(pdgfab)

CSAI:

133421623(pdgfab) 133452227

XMA:	102226782(pdgfa) 102233791

XCO:	114145269 114160156(pdgfa)

XHE:	116720596 116735865(pdgfa)

PRET:

103469195(pdgfa) 103476211

PFOR:

103141010(pdgfa) 103154828

PLAI:

106936519 106942707(pdgfa)

PMEI:

106904598 106915785(pdgfa)

GAF:	122822550(pdgfab) 122830142

PPRL:

129363603(pdgfab) 129367366

CVG:	107090056 107095213(pdgfa)

CTUL:

119773197(pdgfab) 119796294

GMU:	124863463 124863714 124867911

NFU:	107373888 107376493(pdgfa)

KMR:	108237947 108247650(pdgfab)

ALIM:

106518714(pdgfa) 106522509

NWH:	119420987(pdgfab) 119422948

AOCE:

111562600(pdgfa) 111588207

EJA:	138198021(pdgfab) 138209600

BFRE:

138615798 138623344(pdgfab)

MCEP:

124998222(pdgfab) 124999936

CSEM:

103383219 103393040

POV:	109638650(pdgfa) 109639258

SSEN:

122770440 122785574(pdgfab)

HHIP:

117761949 117766492(pdgfab)

HSP:	118115566 118123505(pdgfab)

PPLT:

128436795 128459056(pdgfab)

SMAU:

118288941(pdgfab) 118312537

LCF:	108886167(pdgfab) 108887178

SDU:	111216525 111227111(pdgfa)

SLAL:

111667551(pdgfa) 111673426

XGL:	120788420(pdgfab) 120800741

HCQ:	109510962 109517731

SSCV:

125968948 125983657(pdgfab)

SBIA:

133505785 133515108(pdgfab)

PEE:	133404330 133415223(pdgfab)

PTAO:

133466036(pdgfab) 133477294

BPEC:

110169079(pdgfa)

MALB:

109952877 109972908(pdgfa)

BSPL:

114860735(pdgfab) 114862573

SJO:	128365180 128378975(pdgfab)

SSCO:

133986595 133999545(pdgfab)

SASA:

106564521 106564525 106590378 106601849 106606462

STRU:

115147415 115171767 115178656 115207403

OTW:	112236162 112241368

OMY:	100136119 110485559 110518436 118938428

OGO:	123999192 123999674 124016527

ONE:	115125364(pdgfa)

OKI:	109876032 116355530 116360001 116363050

OKE:	118382184 118382497 127931935

SALP:

112074508 112075283

SNH:	120032526 120032527 120036319 120042520

CCLU:

121551784 121551859 121553960

ELS:	105012099 105021652

SFM:	108930223(pdgfa)

PKI:	111843309 111860586

AANG:

118219868

CCOG:

133112543 133114725

LOC:	102685958(pdgfa)

PSPA:

121300937 121330521

ARUT:

117417838 117431157

PSEX:

120542103

LCM:	102352946(PDGFA)

CMK:	103175503 103178687

RTP:	109916423 109936774

CPLA:

122560577 122562174

HOC:

132825167

LERI:

129706951 129708296

PMRN:

116956877(PDGFA)

LRJ:	133347413(PDGFA)

BBEL:

BMOR:

BPHI:

AAGE:

OFU:

ATRA:

GMW:

LGLY:

CSTB:

RMP:

Reference

PMID:3422746

Authors

Bonthron DT, Morton CC, Orkin SH, Collins T

Title

Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing.

Journal

Proc Natl Acad Sci U S A 85:1492-6 (1988)
DOI:10.1073/pnas.85.5.1492

Sequence

[hsa:5154]

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (38)   
   KEGG PATHWAY (38)   
Disease (2)   
   KEGG DISEASE (2)   
Gene (798)   
   KEGG GENES (590)   
   KEGG MGENES (51)   
   RefGene (153)   
   OC (4)   
Literature (1)   
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