| Entry |
|
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| Name |
Oxycodone hydrochloride hydrate (JP18) |
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| Formula |
C18H21NO4. 3H2O. HCl
|
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| Exact mass |
405.1554
|
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| Mol weight |
405.87
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Neuropsychiatric agent
DG01564 Opioid receptor agonist
Analgesic
DG01984 Opioid analgesics
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
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| Remark |
| Therapeutic category: | 8119 |
| Product (DG00813): | D05312<US> D00847<US> D05462<JP> |
|
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| Efficacy |
Analgesic (narcotic), Opioid receptor agonist |
|---|
| Comment |
Opium alkaloid
|
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]; CYP2D6 [HSA: 1565]
|
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| Interaction |
|
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| Structure map |
| map07224 | Opioid receptor agonists/antagonists |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N02 ANALGESICS
N02A OPIOIDS
N02AA Natural opium alkaloids
N02AA05 Oxycodone
D05462 Oxycodone hydrochloride hydrate (JP18) <JP>
USP drug classification [BR:br08302]
Analgesics
Opioid Analgesics, Long-acting
Oxycodone
D05462 Oxycodone hydrochloride hydrate (JP18)
Opioid Analgesics, Short-acting
Oxycodone
D05462 Oxycodone hydrochloride hydrate (JP18)
Therapeutic category of drugs in Japan [BR:br08301]
8 Narcotics
81 Alkaloidal narcotics
811 Opium alkaloids
8119 Others
D05462 Oxycodone hydrochloride hydrate (JP18)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG00813 Oxycodone
D05462 Oxycodone hydrochloride hydrate
Analgesic
DG01984 Opioid analgesics
DG00813 Oxycodone
D05462 Oxycodone hydrochloride hydrate
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00813 Oxycodone
D05462 Oxycodone hydrochloride hydrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00813 Oxycodone
D05462 Oxycodone hydrochloride hydrate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Opioid
OPRM1
D05462 Oxycodone hydrochloride hydrate (JP18) <JP>
OPRK1
D05462 Oxycodone hydrochloride hydrate (JP18) <JP>
OPRD1
D05462 Oxycodone hydrochloride hydrate (JP18) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D05462 Oxycodone hydrochloride hydrate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D05462
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG00813 Oxycodone
Analgesic
DG01984 Opioid analgesics
DG00813 Oxycodone
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00813 Oxycodone
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00813 Oxycodone
|
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| Other DBs |
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| KCF data |
ATOM 27
1 X Cl 16.4762 -9.1832
2 O0 O 17.1806 -11.8405
3 C1z C 7.4494 -10.6994
4 C8y C 7.4494 -9.3754
5 C1z C 8.6340 -11.3961
6 C1y C 6.3345 -11.3265
7 C1x C 8.6340 -10.0723
8 C8y C 6.3345 -8.7483
9 C8y C 8.6340 -8.7483
10 C1y C 9.7489 -10.6994
11 C1x C 8.6340 -12.6504
12 O2x O 5.0106 -10.0025
13 C5x C 6.3345 -12.6504
14 C1x C 10.8637 -10.0723
15 C8y C 6.3345 -7.4244
16 C1x C 9.7489 -9.4451
17 C8x C 8.6340 -7.4244
18 N1y N 10.8637 -11.3961
19 C1x C 7.4494 -13.3472
20 O5x O 5.2197 -13.3472
21 C8x C 7.5191 -6.7973
22 O2a O 5.2197 -6.7973
23 C1a C 4.0351 -7.4244
24 O1a O 9.8882 -12.3020
25 C1a C 12.2626 -11.3961
26 O0 O 17.1806 -11.8405
27 O0 O 17.1806 -11.8405
BOND 27
1 3 4 1
2 3 5 1
3 3 6 1
4 3 7 1 #Up
5 4 8 2
6 4 9 1
7 5 10 1
8 5 11 1
9 6 12 1 #Down
10 6 13 1
11 7 14 1
12 8 15 1
13 9 16 1
14 9 17 2
15 10 18 1 #Up
16 11 19 1
17 13 20 2
18 15 21 2
19 15 22 1
20 22 23 1
21 8 12 1
22 10 16 1
23 13 19 1
24 14 18 1
25 17 21 1
26 5 24 1 #Up
27 18 25 1
BRACKET 1 14.9100 -12.8100 14.9100 -10.8500
1 17.7100 -10.8500 17.7100 -12.8100
1 3
ORIGINAL 1 2
REPEAT 1 26 27
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