| Entry |
|
|---|
| Name |
Oxycodone (USAN/INN) |
|---|
| Product |
|
|---|
| Formula |
C18H21NO4
|
|---|
| Exact mass |
315.1471
|
|---|
| Mol weight |
315.36
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01564 Opioid receptor agonist
Analgesic
DG01984 Opioid analgesics
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG00813): | D05312<US> D00847<US> D05462<JP> |
|
|---|
| Efficacy |
Analgesic (narcotic), Opioid receptor agonist |
|---|
| Comment |
Opium alkaloid
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]; CYP2D6 [HSA: 1565]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07224 | Opioid receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N02 ANALGESICS
N02A OPIOIDS
N02AA Natural opium alkaloids
N02AA05 Oxycodone
D05312 Oxycodone (USAN/INN) <US>
USP drug classification [BR:br08302]
Analgesics
Opioid Analgesics, Long-acting
Oxycodone
D05312 Oxycodone (USAN/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG00813 Oxycodone
D05312 Oxycodone
Analgesic
DG01984 Opioid analgesics
DG00813 Oxycodone
D05312 Oxycodone
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00813 Oxycodone
D05312 Oxycodone
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00813 Oxycodone
D05312 Oxycodone
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Opioid
OPRM1
D05312 Oxycodone (USAN/INN) <US>
OPRK1
D05312 Oxycodone (USAN/INN) <US>
OPRD1
D05312 Oxycodone (USAN/INN) <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D05312
Narcotics and psychotropics in Japan [br08308.html]
Narcotics by Control Act Article 2 Table 1 (76 substances)
D05312
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG00813 Oxycodone
Analgesic
DG01984 Opioid analgesics
DG00813 Oxycodone
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00813 Oxycodone
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00813 Oxycodone
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 23
1 C1z C 23.8762 -18.4036
2 C8y C 23.8702 -17.0454
3 C1z C 25.0479 -19.0741
4 C1y C 22.7161 -19.0858
5 C8y C 22.6985 -16.3692
6 C8y C 25.0420 -16.3692
7 C1y C 26.2139 -18.3862
8 C1x C 25.0536 -20.4149
9 O1a O 26.2139 -20.0187
10 O2x O 22.0106 -17.7452
11 C5x C 22.7219 -20.4265
12 C8y C 22.6985 -15.0168
13 C1x C 26.2139 -17.0395
14 C8x C 25.0420 -15.0168
15 N1y N 27.3797 -19.0624
16 C1x C 23.8936 -21.0970
17 O5x O 21.5385 -21.0911
18 C8x C 23.8702 -14.3406
19 O2a O 21.5211 -14.3406
20 C1a C 28.7321 -19.0624
21 C1x C 27.3797 -17.7324
22 C1x C 25.0886 -17.7036
23 C1a C 20.2830 -15.0594
BOND 27
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 2
6 3 7 1
7 3 8 1
8 3 9 1 #Up
9 4 10 1 #Down
10 4 11 1
11 5 12 2
12 6 13 1
13 6 14 1
14 7 15 1 #Up
15 8 16 1
16 11 17 2
17 12 18 1
18 12 19 1
19 15 20 1
20 5 10 1
21 7 13 1
22 11 16 1
23 14 18 2
24 15 21 1
25 1 22 1 #Up
26 22 21 1
27 19 23 1
|
|---|