| Entry |
|
|---|
| Name |
Polythiazide (JAN/USAN/INN);
Renese (TN) |
|---|
| Formula |
C11H13ClF3N3O4S3
|
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| Exact mass |
438.9709
|
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| Mol weight |
439.89
|
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| Structure |
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| Simcomp |
|
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| Class |
|
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| Remark |
|
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| Efficacy |
Antihypertensive, Diuretic, Na+-Cl- symport inhibitor |
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| Comment |
Thiazides
|
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| Target |
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| Interaction |
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| Structure map |
| map07017 | Sulfonamide derivatives - diuretics |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C03 DIURETICS
C03A LOW-CEILING DIURETICS, THIAZIDES
C03AA Thiazides, plain
C03AA05 Polythiazide
D00657 Polythiazide (JAN/USAN/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG03231 Antihypertensive
DG01749 Thiazide diuretic
D00657 Polythiazide
DG01690 Sulfonamide diuretic
DG01749 Thiazide diuretic
D00657 Polythiazide
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC12
SLC12A3 (TSC)
D00657 Polythiazide (JAN/USAN/INN)
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| Other DBs |
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| KCF data |
ATOM 25
1 C8y C 25.0405 -17.2302
2 C8y C 25.0346 -15.8323
3 N1x N 23.8290 -17.9408
4 C8x C 26.2402 -17.9350
5 C8x C 26.2402 -15.1334
6 S2x S 23.8173 -15.1393
7 C1y C 22.6117 -17.2418
8 C8y C 27.4575 -17.2302
9 C8y C 27.4575 -15.8323
10 N1y N 22.6060 -15.8383
11 O3c O 25.0405 -14.4288
12 O3c O 22.6117 -14.4230
13 C1b C 21.4061 -17.9408
14 X Cl 28.6748 -17.9291
15 S4a S 28.6689 -15.1334
16 C1a C 21.4003 -15.1334
17 S2a S 20.2004 -17.2361
18 N1a N 29.8804 -14.4288
19 O3c O 29.8745 -15.8207
20 O3c O 27.4575 -14.4230
21 C1b C 18.9950 -17.9408
22 C1d C 17.7834 -17.2361
23 X F 16.5721 -17.9408
24 X F 17.7894 -15.8383
25 X F 16.5721 -16.5313
BOND 26
1 1 2 2
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 1
7 4 8 2
8 5 9 2
9 6 10 1
10 6 11 2
11 6 12 2
12 7 13 1
13 8 14 1
14 9 15 1
15 10 16 1
16 13 17 1
17 15 18 1
18 15 19 2
19 15 20 2
20 17 21 1
21 21 22 1
22 22 23 1
23 22 24 1
24 22 25 1
25 7 10 1
26 8 9 1
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