KEGG ORTHOLOGY: K14426

ORTHOLOGY: K14426

Entry

K14426                      KO

Symbol

SLC12A3, TSC

Name

solute carrier family 12 (sodium/chloride transporter), member 3

Pathway

map04928

Parathyroid hormone synthesis, secretion and action

Disease

H00240

Gitelman syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    K14426  SLC12A3, TSC; solute carrier family 12 (sodium/chloride transporter), member 3
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K14426  SLC12A3, TSC; solute carrier family 12 (sodium/chloride transporter), member 3
   04147 Exosome
    K14426  SLC12A3, TSC; solute carrier family 12 (sodium/chloride transporter), member 3
Transporters [BR:ko02000]
Solute carrier family (SLC)
  SLC12: Electroneutral cation-coupled Cl cotransporter
   K14426  SLC12A3, TSC; solute carrier family 12 (sodium/chloride transporter), member 3
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K14426  SLC12A3, TSC; solute carrier family 12 (sodium/chloride transporter), member 3

Other DBs

GO:

0015378

TC:	2.A.30.1.11 2.A.30.1.12

Genes

HSA:	6559(SLC12A3)

PTR:	454108(SLC12A3)

PPS:	100984936(SLC12A3)

GGO:	101134915(SLC12A3)

PON:	100172399(SLC12A3)

PPYG:

129015777(SLC12A3)

NLE:	100591408(SLC12A3)

HMH:	116470440(SLC12A3)

SSYN:

129457688(SLC12A3)

MCC:	703090(SLC12A3)

MCF:	102146157(SLC12A3)

MTHB:

126943815

MNI:	105494041(SLC12A3)

CSAB:

103233047(SLC12A3)

CATY:

105588283(SLC12A3)

PANU:

100997924(SLC12A3)

TGE:	112614270(SLC12A3)

MLEU:

105533407(SLC12A3)

RRO:	104664040(SLC12A3)

RBB:	108533863(SLC12A3)

TFN:	117087832(SLC12A3)

PTEH:

111541457(SLC12A3)

CANG:

105525390(SLC12A3)

CJC:	100409101(SLC12A3)

SBQ:	101027539(SLC12A3)

CIMI:

108285451(SLC12A3)

ANAN:

105714045(SLC12A3)

CSYR:

103256210(SLC12A3)

MMUR:

105866474(SLC12A3)

LCAT:

123625298(SLC12A3)

PCOQ:

105820880(SLC12A3)

OGA:	100963528(SLC12A3)

MMU:	20497(Slc12a3)

MCAL:

110299903(Slc12a3)

MPAH:

110337378(Slc12a3)

RNO:	54300(Slc12a3)

MCOC:

116067957(Slc12a3)

ANU:	117723127(Slc12a3)

ASYL:

127671754(Slc12a3)

MUN:	110560959(Slc12a3)

CGE:	100758081(Slc12a3)

MAUA:

101824548(Slc12a3)

PROB:

127234867(Slc12a3)

PLEU:

114694508(Slc12a3)

MORG:

121447438(Slc12a3)

MFOT:

126502974

AAMP:

119801986(Slc12a3)

NGI:	103735596(Slc12a3)

HGL:	101704301(Slc12a3)

CPOC:

100726300(Slc12a3)

CCAN:

109687019(Slc12a3)

DORD:

105994412(Slc12a3)

DSP:	122116278(Slc12a3)

PLOP:

125358414(Slc12a3)

NCAR:

124967321

MMMA:

107144843(Slc12a3)

ITI:	101976395(Slc12a3)

OCU:	100009348(SLC12A3)

OPI:	101523113(SLC12A3)

TUP:	102489205(SLC12A3)

GVR:	103590502(SLC12A3)

CFA:	478118(SLC12A3)

CLUD:

112660658(SLC12A3)

VVP:	112929636(SLC12A3)

VLG:	121497115(SLC12A3)

NPO:	129513957(SLC12A3)

AML:	100468795(SLC12A3)

UMR:	103673896(SLC12A3)

UAH:	113252268(SLC12A3)

UAR:	123798431(SLC12A3)

ELK:

111157362

LLV:

125089636

MPUF:

101681872(SLC12A3)

MNP:	132005925(SLC12A3)

MLK:	131818357(SLC12A3)

NVS:	122911426(SLC12A3)

ORO:	101372934(SLC12A3)

EJU:	114201789(SLC12A3)

ZCA:	113935441(SLC12A3)

MLX:	118023759(SLC12A3)

NSU:	110593256(SLC12A3)

LWW:	102747220(SLC12A3)

FCA:	101082284(SLC12A3)

PYU:	121045339(SLC12A3)

PCOO:

112857294(SLC12A3)

PBG:	122494238(SLC12A3)

PVIV:

125152680(SLC12A3)

LRUF:

124511330

PTG:	102962175(SLC12A3)

PPAD:

109270884(SLC12A3)

PUC:

125916022

AJU:

106973305

HHV:	120232129(SLC12A3)

BTA:	404171(SLC12A3)

BOM:	102269839(SLC12A3)

BIU:	109573053(SLC12A3)

BBUB:

102397846(SLC12A3)

BBIS:

105004315(SLC12A3)

CHX:	102188619(SLC12A3)

OAS:	101120940(SLC12A3)

BTAX:

128062960(SLC12A3)

CSUM:

138095783(SLC12A3)

ODA:	120873155(SLC12A3)

CCAD:

122420776(SLC12A3)

MREE:

136160999(SLC12A3)

OVR:	110143992(SLC12A3)

MBEZ:

129547347(SLC12A3)

SSC:	110260927(SLC12A3)

CFR:	102507561(SLC12A3)

CBAI:

105078724(SLC12A3)

CDK:	105102674(SLC12A3)

VPC:	102529077(SLC12A3)

BACU:

103009829(SLC12A3)

BMUS:

118885658(SLC12A3)

LVE:	103077135(SLC12A3)

OOR:	101277558(SLC12A3)

DLE:	111165342(SLC12A3)

PCAD:

102996946

PSIU:

116744324(SLC12A3)

NASI:

112401267(SLC12A3)

ECB:	100051953(SLC12A3) 100072585

EPZ:	103556085(SLC12A3) 103559531

EAI:	106822240(SLC12A3) 106833308

MYB:	102244540(SLC12A3)

MYD:	102772614(SLC12A3)

MMYO:

118674580(SLC12A3)

MLF:	102439299(SLC12A3)

MDT:	132217556(SLC12A3)

PKL:	118720531(SLC12A3)

EFUS:

103295839(SLC12A3)

MNA:	107543464(SLC12A3)

DRO:	112296762(SLC12A3)

SHON:

118983954(SLC12A3)

AJM:	119046429(SLC12A3)

PDIC:

114488164(SLC12A3)

PHAS:

123806025(SLC12A3)

MMF:	118638507(SLC12A3)

PPAM:

129068145(SLC12A3)

HAI:	109395642(SLC12A3)

RFQ:	117034328(SLC12A3)

PALE:

102887237(SLC12A3)

PGIG:

120617309(SLC12A3)

PVP:	105292072(SLC12A3)

RAY:	107499668(SLC12A3)

MJV:	108405056(SLC12A3)

TOD:	119249222(SLC12A3)

SARA:

101544115(SLC12A3)

SFUM:

130043930(SLC12A3)

SETR:

126027139(SLC12A3)

LAV:	100655099(SLC12A3)

TMU:

101354056

ETF:	101651768(SLC12A3)

DNM:	101414045(SLC12A3)

MDO:	100015656(SLC12A3)

GAS:	123237300(SLC12A3)

SHR:	100916687(SLC12A3)

AFZ:

127550739

PCW:	110193769(SLC12A3)

TVP:	118843336(SLC12A3)

PBRV:

138176858(SLC12A3)

OAA:	100079891(SLC12A3) 103167193

TACU:

119920887 119934168(SLC12A3)

GGA:	415692(SLC12A3)

PCOC:

116243901(SLC12A3)

MGP:	100544510(SLC12A3)

CJO:	107319170(SLC12A3)

TPAI:

128081720(SLC12A3)

LMUT:

125699060(SLC12A3)

NMEL:

110404593(SLC12A3)

APLA:

101792018

ACYG:

106043062(SLC12A3)

CATA:

118246366(SLC12A3)

AFUL:

116494028(SLC12A3)

TGU:	100222851(SLC12A3)

LSR:	110473022(SLC12A3)

SCAN:

103816660(SLC12A3)

PMOA:

120508040(SLC12A3)

OTC:	121333881(SLC12A3)

PRUF:

121348802(SLC12A3)

GFR:	102040892(SLC12A3)

FAB:	101806697(SLC12A3)

OMA:	130257923(SLC12A3)

PHI:	102100674(SLC12A3)

PMAJ:

107209926(SLC12A3)

CCAE:

111934542(SLC12A3)

CCW:	104687505(SLC12A3)

CBRC:

103620163(SLC12A3)

ACOE:

138116774(SLC12A3)

ETL:	114069809(SLC12A3)

ZAB:	102073653(SLC12A3)

ZLE:	135452635(SLC12A3)

ACHL:

103811790(SLC12A3)

SVG:	106855783(SLC12A3)

MMEA:

130572697(SLC12A3)

HRT:	120757751(SLC12A3)

SATI:

136366598(SLC12A3)

FPG:	101920229(SLC12A3)

FCH:	102047925(SLC12A3)

NNT:	104403120(SLC12A3)

SHAB:

115600776(SLC12A3) 115619171

ACUN:

113484318(SLC12A3)

TALA:

116965965(SLC12A3)

ACHC:

115345966(SLC12A3)

HLE:	104842181(SLC12A3)

AGEN:

126040655

HHAR:

128145843(SLC12A3)

GCL:

127021043

LDI:	104345955(SLC12A3)

MNB:	103776153(SLC12A3)

DPUB:

104299039(SLC12A3)

PPUS:

135184586(SLC12A3)

BRHI:

104496610

EGZ:	104130280(SLC12A3)

NNI:	104016381(SLC12A3)

PCRI:

104029763(SLC12A3)

PCAO:

104053007(SLC12A3)

PADL:

103914251(SLC12A3)

AFOR:

103896883(SLC12A3)

CLV:	102098891(SLC12A3)

MUI:	104547205(SLC12A3)

CMAC:

104478211(SLC12A3)

CUCA:

104055952(SLC12A3)

OHA:	104334776(SLC12A3)

ACAR:

104531971(SLC12A3)

CPEA:

104386320(SLC12A3)

CVF:	104293453(SLC12A3)

RTD:	128909360(SLC12A3)

AAM:	106490058(SLC12A3)

AROW:

112973914(SLC12A3)

NPD:	112943247(SLC12A3)

TGT:	104575145(SLC12A3)

DNE:	112990429(SLC12A3)

SCAM:

104146394(SLC12A3)

ASN:	102378725(SLC12A3)

AMJ:	102569535 102573736(SLC12A3)

CPOO:

109320547(SLC12A3)

GGN:	109294771(SLC12A3)

PSS:	102453868(SLC12A3)

CMY:	102937228(SLC12A3) 102942122

CCAY:

125620689(SLC12A3) 125622066

DCC:	119841143(SLC12A3)

CPIC:

101937119(SLC12A3) 101946804

TST:	117885380 117886776(SLC12A3)

CABI:

116816453 116821131(SLC12A3)

MRV:	120380553 120384521(SLC12A3)

ACS:	100558510 100562387(slc12a3) 100566888

ASAO:

132777715 132783209(SLC12A3)

PVT:	110085697(SLC12A3) 110089566

SUND:

121914450(SLC12A3) 121935022

PBI:	103049364 103054825(SLC12A3)

PMUR:

107292321 107295251(SLC12A3)

CTIG:

120311014 120312717(SLC12A3)

TSR:	106549928 106552530(SLC12A3)

PGUT:

117662186 117670378(SLC12A3)

APRI:

131184329(SLC12A3) 131197028

PTEX:

113445271(SLC12A3) 113449561

NSS:	113414897(SLC12A3) 113425314

VKO:	123019456 123025405(SLC12A3)

PMUA:

114582523 114601770(SLC12A3)

PRAF:

128399302 128418985(SLC12A3)

ZVI:	118086901(SLC12A3) 118095256

HCG:	128330289 128334383(SLC12A3)

GJA:	107116167 107118983(SLC12A3)

STOW:

125443750(SLC12A3) 125444723

EMC:	129338628 129343956(SLC12A3)

XLA:	108707046(slc12a3l.S) 108714020

XTR:	100038063(slc12a3l) 100494755(slc12a3)

NPR:	108786171(SLC12A3) 108788651

RTEM:

120917701(SLC12A3) 120924882

BBUF:

120980300(SLC12A3) 120990818

BGAR:

122920470(SLC12A3) 122928303

MUO:	115457230 115470500(SLC12A3)

GSH:	117349594 117359140(SLC12A3)

DRE:	562763(slc12a10.3) 565439(slc12a3) 570849(slc12a10.1)

SRX:	107707297 107707299 107738747(slc12a3) 107740340 107751531

SANH:

107657180 107657181 107686348(slc12a3) 107702760 107702778

SGH:	107549636(slc12a3) 107566595 107571968 107571969 107583876

CCAR:

109069477 109070890 109080591(slc12a3) 109089906

CAUA:

113041654 113041658 113079174 113079177 113105477 113118329(slc12a3)

CGIB:

127962632 127962633 127977840 128017462 128017463

PTET:

122323111(slc12a3) 122348972 122348973(slc12a10.3) 122348974(slc12a10.1)

LROH:

127168441(slc12a10.1) 127180995(slc12a3)

OMC:	131524303(slc12a3) 131543633 131543815(slc12a10.1) 131543816(slc12a10.3)

PPRM:

120461209(slc12a10.1) 120461211 120461214 120494128(slc12a3)

RKG:	130094722(slc12a3)

MAMB:

125254563(slc12a3) 125265278(slc12a10.1) 125265279(slc12a10.3) 125265280

CIDE:

127499343 127516148 127516149 127516150

CERY:

137023331(slc12a3) 137029943(slc12a10.1) 137029945 137029946

MASI:

127417389 127448755 127452761 127455787

TROS:

130553591(slc12a10.3) 130562587(slc12a10.1) 130563018(slc12a3)

TDW:	130417397 130417404(slc12a10.3) 130417408 130420550 130435645(slc12a3)

MANU:

129419158(slc12a3) 129436322(slc12a10.1) 129436327 129436450

IPU:

108264411

IFU:	128606666(slc12a3)

PHYP:

113534358(slc12a3) 113544336

SMEO:

124381401(slc12a10.1) 124395734(slc12a3)

TFD:	113652453(slc12a3) 113660681(slc12a10.1)

TVC:	132841835(slc12a10.1) 132851267(slc12a3)

TRN:	134323250(slc12a3)

AMEX:

103034392(slc12a10.1) 103040747(slc12a3)

CMAO:

118816767(slc12a10.1) 118817954(slc12a3)

EEE:	113588838 113589789(slc12a3)

CHAR:

105892423(slc12a3) 105898409 116224578

SPIL:

134059510 134094252(slc12a3)

TRU:	100653414(slc12a3)

TFS:	130536355(slc12a3)

LCO:	104925780 104938372(slc12a3)

NCC:

104941086

TBEN:

117484457(slc12a3) 117498037(slc12a10.1)

CGOB:

115004563 115009527(slc12a3) 115023693

PGEO:

117449997(slc12a3) 117463701

GACU:

117553229(slc12a3) 117555551

EMAC:

134872360 134884180(slc12a3)

ELY:	117246156(slc12a10.1) 117261705(slc12a3)

EFO:	125883571(slc12a10.1) 125887524(slc12a3)

PLEP:

121949867(slc12a3) 121961842(slc12a10.1)

SLUC:

116048674(slc12a3) 116053319 116053320 116053342

ECRA:

117934997 117934999 117948602(slc12a3)

ESP:	116669457 116693943(slc12a3) 116707103

PFLV:

114545380 114545520 114545829 114559582(slc12a3)

GAT:	120809759(slc12a3) 120821861 120821862

PPUG:

119196008(slc12a3) 119222881 119223077

AFB:	129093016 129107957(slc12a3)

CLUM:

117732665(slc12a3) 117747504

CANA:

137791949 137803640(slc12a3)

CVE:	137880871 137881150(slc12a3) 137885863

MSAM:

119894298(slc12a3) 119912124

SCHU:

122870594 122875324(slc12a3)

CUD:	121514875(slc12a3)

SPUL:

138613451(slc12a3)

LMIX:

132973399 132973402

ALAT:

119024244(slc12a3) 119027164(slc12a10.1)

ASTR:

137593555(slc12a3)

MZE:	101472929(slc12a3) 101475294 101477129

ONL:	100700766 100703132(slc12a3) 100712309 100712574

OAU:	116321204 116321205 116321210 116327431(slc12a3)

OLA:	100170630(slc12a3) 101155566 101161366

OML:	112141089(slc12a10.1) 112141167(slc12a3) 112155947

CSAI:

133420460(slc12a10.1) 133444649(slc12a3)

XMA:	102217745(slc12a3) 102220553 102220820

XCO:	114149994(slc12a3) 114157098 114157242

XHE:	116729657(slc12a3) 116732317 116732318

PRET:

103466269(slc12a3) 103480277 103480278

PFOR:

103129296 103129297 103142465 103142466(slc12a3) 103144670

PLAI:

106937994 106942767 106960283 106962731 106963412(slc12a3)

PMEI:

106903664(slc12a3) 106912129 106933487

GAF:	122819849 122819851 122835894(slc12a3)

PPRL:

129355632 129358937(slc12a3) 129378308

CVG:	107096273(slc12a3) 107102099

CTUL:

119776172(slc12a3) 119778213

GMU:	124856013(slc12a3) 124880099 124880110

NFU:	107377151 107377152 107389243(slc12a3)

KMR:	108243481(slc12a3) 108250796 108251153

ALIM:

106528604 106528624 106535917(slc12a3)

NWH:	119408489 119408509 119414812 119414823 119415506(slc12a3)

AOCE:

111563506 111569002 111571725

EJA:	138203869 138206013(slc12a3)

BFRE:

138630119(slc12a3) 138634994

MCEP:

125005648(slc12a10.1) 125014298(slc12a3)

CSEM:

103379615(slc12a3) 103385885

POV:	109641719 109642021(slc12a3)

SSEN:

122766220(slc12a10.1) 122776494(slc12a3)

HHIP:

117762965(slc12a3) 117779091

HSP:	118102966 118109634(slc12a3)

PPLT:

128430556 128444401(slc12a3)

SMAU:

118290345 118314995(slc12a3)

LCF:	108890832 108890833 108902322

SDU:	111222465(slc12a3) 111239963

SLAL:

111658752(slc12a3) 111661707

XGL:	120792816(slc12a3) 120797199(slc12a10.1)

HCQ:	109520773(slc12a3)

SSCV:

125971129(slc12a3)

SBIA:

133501625(slc12a3)

PEE:	133402584(slc12a3)

PTAO:

133478125(slc12a3)

BPEC:

110153882 110169711(slc12a3)

MALB:

109952881 109952882 109952887 109968425(slc12a3)

BSPL:

114857668(slc12a3) 114866129 114866197

SJO:	128359337(slc12a3) 128384341

SSCO:

133982552(slc12a3) 134005629

SASA:

106560848(slc12a3)

STRU:

115196823

OTW:	112218525(slc12a3)

OMY:	110494770(slc12a3)

OGO:	124037401(slc12a3)

ONE:	115134298(slc12a3)

OKI:	109867264(slc12a3)

OKE:	118396134(slc12a3)

OMM:	135508715(slc12a3)

SALP:

111962351(slc12a3)

SNH:	120066671(slc12a3)

CCLU:

121531855(slc12a3)

ELS:	105007990 105018495(slc12a3)

SFM:	108918988(slc12a3) 108940933

PKI:	111851895(slc12a3) 111858094

AANG:

118226757(slc12a3) 118231028

AROT:

135254870(slc12a3) 135258545

CCOG:

133120298 133130126(slc12a3)

LOC:	102690844(slc12a3) 102692728

PSPA:

121305247 121307364 121325199

ARUT:

117398349 117398854 117424058 117425645

PSEX:

120523878 120535265(slc12a3)

LCM:	102348624 102364565(SLC12A3)

CMK:	103187883(slc12a3)

RTP:	109927757(slc12a3)

CPLA:

122558743(slc12a3)

HOC:	132823765(slc12a3)

LERI:

129705137(slc12a3)

PMRN:

116944213 116945751 116945752 116945799

LRJ:	133339434 133339443 133339582 133350915

» show all

Reference

PMID:12739168

Authors

Hebert SC, Mount DB, Gamba G

Title

Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family.

Journal

Pflugers Arch 447:580-93 (2004)
DOI:10.1007/s00424-003-1066-3

Sequence

[hsa:6559]

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