| Entry |
|
|---|
| Name |
Quinethazone (JAN/INN);
Hydromox (TN) |
|---|
| Formula |
C10H12ClN3O3S
|
|---|
| Exact mass |
289.0288
|
|---|
| Mol weight |
289.74
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG03231 Antihypertensive
DG02992 Thiazide related diuretic
DG01690 Sulfonamide diuretic
DG02992 Thiazide related diuretic
|
|---|
| Remark |
|
|---|
| Efficacy |
Diuretic, Na+-Cl- symport inhibitor |
|---|
| Comment |
Sulfonamide derivative
|
|---|
| Target |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07017 | Sulfonamide derivatives - diuretics |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C03 DIURETICS
C03B LOW-CEILING DIURETICS, EXCL. THIAZIDES
C03BA Sulfonamides, plain
C03BA02 Quinethazone
D00461 Quinethazone (JAN/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG03231 Antihypertensive
DG02992 Thiazide related diuretic
D00461 Quinethazone
DG01690 Sulfonamide diuretic
DG02992 Thiazide related diuretic
D00461 Quinethazone
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC12
SLC12A1 (NKCC2)
D00461 Quinethazone (JAN/INN)
SLC12A3 (TSC)
D00461 Quinethazone (JAN/INN)
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 18
1 C8y C 25.3928 -19.8397
2 C8y C 25.3928 -18.4507
3 N1x N 26.6008 -20.5341
4 C8x C 24.1788 -20.5341
5 C8x C 24.1788 -17.7504
6 C5x C 26.6008 -17.7504
7 C1y C 27.8088 -19.8397
8 C8y C 22.9650 -19.8397
9 C8y C 22.9650 -18.4507
10 N1x N 27.8088 -18.4507
11 O5x O 26.6008 -16.3322
12 C1b C 29.0343 -20.5341
13 X Cl 21.7453 -20.5341
14 S4a S 21.7453 -17.7504
15 C1a C 30.2423 -19.8221
16 N1a N 20.5315 -17.0442
17 O3c O 21.0450 -18.9642
18 O3c O 22.4515 -16.5307
BOND 19
1 1 2 2
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 1
7 4 8 2
8 5 9 2
9 6 10 1
10 6 11 2
11 7 12 1
12 8 13 1
13 9 14 1
14 12 15 1
15 14 16 1
16 14 17 2
17 14 18 2
18 7 10 1
19 8 9 1
|
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