[go: up one dir, main page]
More Web Proxy on the site http://driver.im/
KEGG   NETWORK: N00086
Entry
N00086                      Network                                
Name
Notch signaling pathway
Definition
(DLL,JAG) -> NOTCH -> (NICD+RBPJ) => (HES1,HEY1)
  Expanded
(28514,10683,54567,182,3714) -> (4851,4853,4854,4855) -> (C22528+(3516,11317)) => (3280,23462)
Class
nt06511 NOTCH signaling
nt06270 Breast cancer
nt06216 NOTCH signaling (cancer)
nt06465 Prion disease
nt06166 Human papillomavirus (HPV)
Type
Reference
Pathway
hsa04330  Notch signaling pathway
Gene
28514  DLL1; delta like canonical Notch ligand 1
10683  DLL3; delta like canonical Notch ligand 3
54567  DLL4; delta like canonical Notch ligand 4
182  JAG1; jagged 1
3714  JAG2; jagged 2
4851  NOTCH1; notch 1
4853  NOTCH2; notch 2
4854  NOTCH3; notch 3
4855  NOTCH4; notch 4
3516  RBPJ; recombination signal binding protein for immunoglobulin kappa J region
11317  RBPJL; recombination signal binding protein for immunoglobulin kappa J region like
3280  HES1; hes family bHLH transcription factor 1
23462  HEY1; hes related family bHLH transcription factor with YRPW motif 1
Metabolite
C22528  Notch intracellular domain
Reference
PMID:21508972
  Authors
Ranganathan P, Weaver KL, Capobianco AJ
  Title
Notch signalling in solid tumours: a little bit of everything but not all the time.
  Journal
Nat Rev Cancer 11:338-51 (2011)
DOI:10.1038/nrc3035
Reference
PMID:19379690
  Authors
Kopan R, Ilagan MX
  Title
The canonical Notch signaling pathway: unfolding the activation mechanism.
  Journal
Cell 137:216-33 (2009)
DOI:10.1016/j.cell.2009.03.045
Reference
PMID:23729744
  Authors
Hori K, Sen A, Artavanis-Tsakonas S
  Title
Notch signaling at a glance.
  Journal
J Cell Sci 126:2135-40 (2013)
DOI:10.1242/jcs.127308
Reference
PMID:16921404
  Authors
Bray SJ
  Title
Notch signalling: a simple pathway becomes complex.
  Journal
Nat Rev Mol Cell Biol 7:678-89 (2006)
DOI:10.1038/nrm2009

  All links  
Pathway (1)   
   KEGG PATHWAY (1)   
Chemical substance (1)   
   KEGG COMPOUND (1)   
Gene (13)   
   KEGG GENES (13)   
Literature (4)   
   PubMed (4)   
All databases (19)   

Download RDF
DBGET integrated database retrieval system