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Network variation - Prion disease
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ENTRY
nt06465
Name
Prion disease
Category
Disease view; Neurodegenerative disease
Pathway
hsa05020
Prion disease
Disease
H00061
Prion disease
Display
drug-target relation
disease type
Calcium signaling
N00984
Glutamate
→
GRM5
→
GNAQ
→
PLCB
→
IP3
→
ITPR
→
Ca2+
−
MCU
→
Ca2+(mito)
−
MPTP
→
CYCS
=
APAF1
→
CASP9
→
(CASP3,CASP7)
N01199
PRNP*
→
(
RYR
,
ITPR
)
→
Ca2+
−
MCU
→
Ca2
+
(
mito
)
−
MPTP
→
CYCS
=
APAF1
→
CASP9
→
CASP3
N00967
Ca2+(extracellular..
−
VGCC
→
Ca2+
−
MCU
→
Ca2+(mito)
−
MPTP
→
CYCS
=
APAF1
→
CASP9
→
(CASP3,CASP7)
N01201
PRNP*
⊣
VGCC
(
N
,
L-type
)
→
Ca2+
N00970
Glutamate
→
NMDAR
→
Ca2+
N01200
PRNP*
→
NMDAR
→
Ca2+
−
MCU
→
Ca2
+
(
mito
)
−
MPTP
→
CYCS
=
APAF1
→
CASP9
→
CASP3
Ubiquitin-proteasome system
N01029
(Protein+UB)
−
26S
→
Peptide
N01197
PRNP*
⊣
26S
Unfolded protein response (UPR) signaling
N01009
EIF2AK3
→
EIF2S1
→
ATF4
⇒
DDIT3
N01198
PRNP*
⊣
BIP
⊣
EIF2AK3
→
EIF2S1
→
ATF4
⇒
DDIT3
PI3K signaling
N01204
PRNP
→
CAV
→
FYN
→
PI3K
→
PRKCD
→
NOX2
→
ERK
→
CREB
⇒
EGR1
N01205
PRNP*
→
CAV
→
FYN
→
PI3K
→
PRKCD
→
NOX2
→
ROS
Microtubule-based transport
N00978
(KIF5+KLC)
=
(TUBA+TUBB)
N01202
PRNP*
→
(
GSK3B
,
CK2
)
⊣
(
KIF5
+
KLC
)
NOTCH signaling
N00086
(DLL,JAG)
→
NOTCH
→
(NICD+RBPJ)
⇒
(HES1,HEY1)
N01203
PRNP*
→
NOTCH1