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Roles for autonomous physiologic agents; an oxygen supply and demand example

Published: 09 December 2007 Publication History

Abstract

In the study of physiologic systems control, lumped parameter and differential equation techniques are standard approaches. Application of these techniques to the study of oxygen supply to tissues is discussed. It is then proposed that progress in dealing with heterogeneous physiologic systems is likely to proceed from the techniques of agent based modeling in the form of autonomous physiologic agents.

References

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Bassingthwaighte 2007. Available via <http://www.physiome.org/model/doku.php?do=show&id=Transport_Physiology%3ACombined_convetion_dision_permeation_reaction%3AArtrial_flow_with_O2_CO2_HCO3_and_H_exchange%3Amodel_detail> {Accessed June 5, 2007}
[2]
Brown, B., and M. Katzper. 1970. Brain Oxygen Supply and Electrical Activity. Neuroelectric Research, ed. D. V. Reynolds and A. E. Sjoberg, Chapter 40. Springfield: C. C. Thomas.
[3]
Dash, R. K. and J. B. Bassingthwaighte. 2006 Simultaneous blood-tissue exchange of oxygen, carbon dioxide, bicarbonate and hydrogen ion. Annals of Biomedical Engineering 34:1129--1148.
[4]
Guyton, A. and J. E. Hall. 2005. Textbook of Medical Physiology. 11th ed. Amsterdam: Elsevier.
[5]
Krogh, A. 1919. The Number and Distribution of Capillaries in Muscle With Calculations of the Oxygen Pressure Head Necessary for Supplying the Tissue. Journal of Physiology (London) 52: 391--409.
[6]
Law, R. 1999. The Physiology of Oxygen Delivery Physiology Issue 10 Article 3. Available via <http://www.nda.ox.ac.uk/wfsa/html/u10/u1003_01.htm> {accessed June 5, 2007}.
[7]
Popel A. S. 1989. Theory of oxygen transport to tissue. Critical Review of Biomedical Engineering. 17(3):257--321.
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Wilensky U. 1999. NetLogo. Available via <http://ccl.northwestern.edu/netlogo> {accessed June 5, 2007}.

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Information & Contributors

Information

Published In

cover image ACM Conferences
WSC '07: Proceedings of the 39th conference on Winter simulation: 40 years! The best is yet to come
December 2007
2659 pages
ISBN:1424413060

Sponsors

  • IIE: Institute of Industrial Engineers
  • INFORMS-SIM: Institute for Operations Research and the Management Sciences: Simulation Society
  • ASA: American Statistical Association
  • IEEE/SMC: Institute of Electrical and Electronics Engineers: Systems, Man, and Cybernetics Society
  • SIGSIM: ACM Special Interest Group on Simulation and Modeling
  • NIST: National Institute of Standards and Technology
  • (SCS): The Society for Modeling and Simulation International

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IEEE Press

Publication History

Published: 09 December 2007

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  • Research-article

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WSC07
Sponsor:
  • IIE
  • INFORMS-SIM
  • ASA
  • IEEE/SMC
  • SIGSIM
  • NIST
  • (SCS)
WSC07: Winter Simulation Conference
December 9 - 12, 2007
Washington D.C.

Acceptance Rates

WSC '07 Paper Acceptance Rate 152 of 244 submissions, 62%;
Overall Acceptance Rate 3,413 of 5,075 submissions, 67%

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