About: VGX-1027

An Entity of Type: chemical substance, from Named Graph: http://dbpedia.org, within Data Space: dbpedia.org

VGX-1027 (GIT-27) is a drug which acts as an immunomodulator. It acts by blocking downstream signalling of the Toll-like receptors TLR2, TLR4 and TLR6, and thereby reducing production of various cytokines, including interleukins and TNF-α. In animal studies it has antiinflammatory effects and has been investigated for conditions such as arthritis and lung inflammation.

Property	Value
dbo:abstract	VGX-1027 (GIT-27) is a drug which acts as an immunomodulator. It acts by blocking downstream signalling of the Toll-like receptors TLR2, TLR4 and TLR6, and thereby reducing production of various cytokines, including interleukins and TNF-α. In animal studies it has antiinflammatory effects and has been investigated for conditions such as arthritis and lung inflammation. (en)
dbo:casNumber	6501-72-0
dbo:chEMBL	1320667
dbo:fdaUniiCode	AKT814N13R
dbo:pubchem	10798271
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dbo:wikiPageWikiLink	dbr:Cytokine dbr:Interleukin dbc:Carboxylic_acids dbr:TLR4 dbr:Toll-like_receptor dbr:Arthritis dbc:Isoxazolines dbr:TLR6 dbc:Immunomodulating_drugs dbr:Antiinflammatory dbr:Immunomodulator dbr:TLR2 dbr:TNF-α
dbp:c	11 (xsd:integer)
dbp:casNumber	6501 (xsd:integer)
dbp:chembl	1320667 (xsd:integer)
dbp:chemspiderid	8973577 (xsd:integer)
dbp:h	11 (xsd:integer)
dbp:iupacName	2 (xsd:integer)
dbp:n	1 (xsd:integer)
dbp:o	3 (xsd:integer)
dbp:pubchem	10798271 (xsd:integer)
dbp:smiles	C1CCCO (en)
dbp:stdinchi	1 (xsd:integer)
dbp:stdinchikey	MUFJHYRCIHHATF-UHFFFAOYSA-N (en)
dbp:unii	AKT814N13R (en)
dbp:wikiPageUsesTemplate	dbt:Drugbox dbt:Pharm-stub dbt:Reflist dbt:Cascite dbt:Fdacite
dcterms:subject	dbc:Carboxylic_acids dbc:Isoxazolines dbc:Immunomodulating_drugs
rdf:type	owl:Thing dul:ChemicalObject dbo:ChemicalSubstance wikidata:Q8386 dbo:Drug
rdfs:comment	VGX-1027 (GIT-27) is a drug which acts as an immunomodulator. It acts by blocking downstream signalling of the Toll-like receptors TLR2, TLR4 and TLR6, and thereby reducing production of various cytokines, including interleukins and TNF-α. In animal studies it has antiinflammatory effects and has been investigated for conditions such as arthritis and lung inflammation. (en)
rdfs:label	VGX-1027 (en)
owl:sameAs	wikidata:VGX-1027 https://global.dbpedia.org/id/FNXrf
prov:wasDerivedFrom	wikipedia-en:VGX-1027?oldid=1073596176&ns=0
foaf:depiction	wiki-commons:Special:FilePath/VGX-1027_structure.png
foaf:isPrimaryTopicOf	wikipedia-en:VGX-1027
is dbo:wikiPageWikiLink of	dbr:M62812
is foaf:primaryTopic of	wikipedia-en:VGX-1027