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- Thioester containing protein 1, often called TEP1 is a key component of the arthropod innate immune system. TEP1 was first identified as a key immunity gene in 2001 through functional studies on Anopheles gambiae mosquitoes. TEP1 is an antimicrobial protein which acts in a system reminiscent of the human complement pathway, which damages the cell membranes of pathogens. Studies have shown that TEP1 is structurally and functionally homologous to the human complement protein C3. TEP1 is now known to be important in the resistance of Anopheles mosquitoes to Plasmodium infection, targeting the malaria parasite during its invasion into the mosquitoes body cavity. Following this discovery insect thioester containing proteins have come under increased scrutiny from the scientific community as possible targets for disease control. TEP1 is coded for by two different alleles TEP1-S and TEP-R which are specific to susceptible and resistant mosquito populations respectively. (en)
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- Thioester-containing protein 1 (en)
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- Thioester containing protein 1, often called TEP1 is a key component of the arthropod innate immune system. TEP1 was first identified as a key immunity gene in 2001 through functional studies on Anopheles gambiae mosquitoes. TEP1 is coded for by two different alleles TEP1-S and TEP-R which are specific to susceptible and resistant mosquito populations respectively. (en)
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- Thioester-containing protein 1 (en)
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