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- The Hallmarks of Cancer (que l'on peut traduire par « les capacités distinctives des cancers ») est un article scientifique majeur écrit par Douglas Hanahan et Robert Weinberg et publié en 2000 dans la revue scientifique Cell. Cet article est devenu le plus cité de la revue Cell. Selon les auteurs, les six capacités distinctives des cancers sont l'autosuffisance en signaux de croissance, l'insensibilité aux signaux inhibiteurs de la croissance, la capacité à éviter l'apoptose, la capacité de se répliquer indéfiniment, l'induction de l'angiogenèse et la capacité à former des métastases. En 2011, Douglas Hanahan et Robert Weinberg publient un nouvel article de synthèse sur les caractéristiques des cancers. Dans cet article, ils identifient deux capacités distinctives émergentes, la dérégulation du métabolisme énergétique cellulaire et la capacité à éviter une destruction par le système immunitaire. Ils mettent aussi en évidence deux caractéristiques favorisant les cancers (mais qui ne sont pas qualifiées de capacités distinctives) ; il s'agit de l'inflammation favorisant les tumeurs ainsi que de l'instabilité et des mutations du génome. (fr)
- The hallmarks of cancer were originally six biological capabilities acquired during the multistep development of human tumors and have since been increased to eight capabilities and two enabling capabilities. The idea was coined by Douglas Hanahan and Robert Weinberg in their paper "The Hallmarks of Cancer" published January 2000 in Cell. These hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis. Underlying these hallmarks are genome instability, which generates the genetic diversity that expedites their acquisition, and inflammation, which fosters multiple hallmark functions. In addition to cancer cells, tumors exhibit another dimension of complexity: they incorporate a community of recruited, ostensibly normal cells that contribute to the acquisition of hallmark traits by creating the “tumor microenvironment.” Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer. In an update published in 2011 ("Hallmarks of cancer: the next generation"), Weinberg and Hanahan proposed two new hallmarks: (1) abnormal metabolic pathways and (2) evasion of the immune system, and two enabling characteristics: (1) genome instability, and (2) inflammation. (en)
- The Hallmarks of Cancer è un articolo scientifico pubblicato nel gennaio del 2000 sulla rivista Cell da e . L'articolo ha fornito la prima definizione sistematica delle differenze tra cellule cancerose e normali (non cancerose), gettando la base per le successive ricerche nel settore. (it)
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- The Hallmarks of Cancer è un articolo scientifico pubblicato nel gennaio del 2000 sulla rivista Cell da e . L'articolo ha fornito la prima definizione sistematica delle differenze tra cellule cancerose e normali (non cancerose), gettando la base per le successive ricerche nel settore. (it)
- The hallmarks of cancer were originally six biological capabilities acquired during the multistep development of human tumors and have since been increased to eight capabilities and two enabling capabilities. The idea was coined by Douglas Hanahan and Robert Weinberg in their paper "The Hallmarks of Cancer" published January 2000 in Cell. (en)
- The Hallmarks of Cancer (que l'on peut traduire par « les capacités distinctives des cancers ») est un article scientifique majeur écrit par Douglas Hanahan et Robert Weinberg et publié en 2000 dans la revue scientifique Cell. Cet article est devenu le plus cité de la revue Cell. Selon les auteurs, les six capacités distinctives des cancers sont l'autosuffisance en signaux de croissance, l'insensibilité aux signaux inhibiteurs de la croissance, la capacité à éviter l'apoptose, la capacité de se répliquer indéfiniment, l'induction de l'angiogenèse et la capacité à former des métastases. (fr)
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