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- PD-1 inhibitors and PD-L1 inhibitors are a group of checkpoint inhibitor anticancer drugs that block the activity of PD-1 and PDL1 immune checkpoint proteins present on the surface of cells. Immune checkpoint inhibitors are emerging as a front-line treatment for several types of cancer. PD-1 and PD-L1 inhibitors act to inhibit the association of the programmed death-ligand 1 (PD-L1) with its receptor, programmed cell death protein 1 (PD-1). The interaction of these cell surface proteins is involved in the suppression of the immune system and occurs following infection to limit the killing of bystander host cells and prevent autoimmune disease. This immune checkpoint is also active in pregnancy, following tissue allografts, and in different types of cancer. (en)
- PD-1/PD-L1抑制剂是一组用于治疗癌症的。和PD-L1都是存在于细胞表面的蛋白质。此类的免疫检查点抑制剂正在成为几种癌症的一线治疗药物。 PD-1/PD-L1抑制剂能抑制程序性死亡配体-1（PD-L1）与其受体程序性死亡蛋白-1（）结合。这些细胞表面蛋白能抑制免疫系统，以限制免疫系统对其附着细胞的杀伤，进而预防自體免疫性疾病 。 这种免疫检查点抑制剂在妊娠期也能使用，也可用于组织器官移植 以及各类癌症 。 (zh)
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- PD-1/PD-L1抑制剂是一组用于治疗癌症的。和PD-L1都是存在于细胞表面的蛋白质。此类的免疫检查点抑制剂正在成为几种癌症的一线治疗药物。 PD-1/PD-L1抑制剂能抑制程序性死亡配体-1（PD-L1）与其受体程序性死亡蛋白-1（）结合。这些细胞表面蛋白能抑制免疫系统，以限制免疫系统对其附着细胞的杀伤，进而预防自體免疫性疾病 。 这种免疫检查点抑制剂在妊娠期也能使用，也可用于组织器官移植 以及各类癌症 。 (zh)
- PD-1 inhibitors and PD-L1 inhibitors are a group of checkpoint inhibitor anticancer drugs that block the activity of PD-1 and PDL1 immune checkpoint proteins present on the surface of cells. Immune checkpoint inhibitors are emerging as a front-line treatment for several types of cancer. (en)
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- PD-1 and PD-L1 inhibitors (en)
- PD-1/PD-L1抑制剂 (zh)
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