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About: IQSEC3

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IQSEC3 is a human gene, known as IQ motif and Sec7 domain 3. It contains an , followed by a and then a PH. It functions as an ARF-GEF for the ARF family of GTPases, which is to say that it causes GDP to release, and GTP to bind, thereby activating the ARF protein. It is highly expressed in the brain, particularly in the amygdala, and is known to have a role in learning. In a largescale phospho screening of the PSD, it was found to be phosphorylated following activation of the NMDAR complex.

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  • IQSEC3 is a human gene, known as IQ motif and Sec7 domain 3. It contains an , followed by a and then a PH. It functions as an ARF-GEF for the ARF family of GTPases, which is to say that it causes GDP to release, and GTP to bind, thereby activating the ARF protein. It is highly expressed in the brain, particularly in the amygdala, and is known to have a role in learning. In a largescale phospho screening of the PSD, it was found to be phosphorylated following activation of the NMDAR complex. IQSEC3 was originally known as 'KIAA1110', under which name it was found to act as a GEF for Arf1 but not Arf6. It is related to the other Arf-GEF protein IQSEC1. (en)
  • IQSEC3 (англ. IQ motif and Sec7 domain 3) – білок, який кодується однойменним геном, розташованим у людей на 12-й хромосомі. Довжина поліпептидного ланцюга білка становить 1 182 амінокислот, а молекулярна маса — 127 621. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Кодований геном білок за функцією належить до фосфопротеїнів. Задіяний у такому біологічному процесі, як альтернативний сплайсинг. Локалізований у цитоплазмі. (uk)
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  • IQSEC3 is a human gene, known as IQ motif and Sec7 domain 3. It contains an , followed by a and then a PH. It functions as an ARF-GEF for the ARF family of GTPases, which is to say that it causes GDP to release, and GTP to bind, thereby activating the ARF protein. It is highly expressed in the brain, particularly in the amygdala, and is known to have a role in learning. In a largescale phospho screening of the PSD, it was found to be phosphorylated following activation of the NMDAR complex. (en)
  • IQSEC3 (англ. IQ motif and Sec7 domain 3) – білок, який кодується однойменним геном, розташованим у людей на 12-й хромосомі. Довжина поліпептидного ланцюга білка становить 1 182 амінокислот, а молекулярна маса — 127 621. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk)
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  • IQSEC3 (en)
  • IQSEC3 (uk)
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