DMPX (3,7-dimethyl-1-propargylxanthine) is a caffeine analog which displays affinity to A2 adenosine receptors, in contrast to the A1 subtype receptors. DMPX had 28× and 15× higher potency than caffeine in blocking peripheral and central -responses. The locomotor stimulation caused by DMPX (ED50 10 μmol/kg) was similarly higher than caffeine.
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