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- The CcdA/CcdB Type II Toxin-antitoxin system is one example of the bacterial toxin-antitoxin (TA) systems that encode two proteins, one a potent inhibitor of cell proliferation (toxin) and the other its specific antidote (antitoxin). These systems preferentially guarantee growth of plasmid-carrying daughter cells in a bacterial population by killing newborn bacteria that have not inherited a plasmid copy at cell division (post-segregational killing). The ccd system (control of cell death) of the F plasmid encodes two proteins, the CcdB protein (101 amino acids; toxin) and the CcdA antidote (72 amino acids). The antidote prevents CcdB toxicity by forming a tight CcdA–CcdB complex. (en)
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- 7695 (xsd:nonNegativeInteger)
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- ccdB dimer in complex with one c-terminal ccdA domain (en)
- CcdB, a topoisomerase toxin from E. coli (en)
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- IPR002712 (en)
- IPR009956 (en)
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- CcdA Antitoxin of Type II Toxin-antitoxin system (en)
- CcdB Toxin of Type II Toxin-antitoxin system (en)
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- PF01845 (en)
- PF07362 (en)
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- The CcdA/CcdB Type II Toxin-antitoxin system is one example of the bacterial toxin-antitoxin (TA) systems that encode two proteins, one a potent inhibitor of cell proliferation (toxin) and the other its specific antidote (antitoxin). These systems preferentially guarantee growth of plasmid-carrying daughter cells in a bacterial population by killing newborn bacteria that have not inherited a plasmid copy at cell division (post-segregational killing). (en)
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- CcdA/CcdB Type II Toxin-antitoxin system (en)
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