Mohammed Yousuff Hussaini is an Indian born American applied mathematician. He is the Sir James Lighthill Professor of Mathematics and Computational Science & Engineering at the Florida State University, United States. Hussaini is also the holder of the TMC Eminent Scholar Chair in High Performance Computing at FSU. He is widely known for his research in scientific computation, particularly in the field of computational fluid dynamics (CFD) and Control and optimization. Hussaini co-authored the popular book Spectral Methods in Fluid Dynamics with Claudio Canuto, Alfio Quarteroni, and Thomas Zang. He is the editor-in-chief of the journal Theoretical and Computational Fluid Dynamics.