[go: up one dir, main page]
More Web Proxy on the site http://driver.im/
Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Mast cells as a source of both preformed and immunologically inducible TNF-α/cachectin

Nature volume 346, pages 274–276 (1990)Cite this article

Abstract

TUMOUR necrosis factor-α (TNF-α)/cachectin is a multifunctional cytokine that has effects in inflammation, sepsis, lipid and protein metabolism, haematopoiesis, angiogenesis and host resistance to parasites and malignancy1–3. TNF-α was first described in activated macrophages1–3, but certain mouse or rat mast cell populations (reviewed in refs 4,5) and some in vitro-derived human cells with cytochemical features of mast cells-basophils6 may also contain products similar to TNF-α. Here we present evidence that resident mouse peritoneal mast cells constitutively contain large amounts of TNF-α bioactivity, whereas cultured, immature mast cells vary in their TNF-α content. IgE-dependent activation of cultured or peritoneal mast cells7 induces extracellular release of TNF-α and augments levels of TNF-α messenger RNA and bioactivity. These findings identify mouse mast cells as an important source of both preformed and immunologically inducible TNF-α, and suggest that release of TNF-α by mast cells may contribute to host defence, the pathophysiology of allergic diseases and other processes dependent on TNF-α.

Access through your institution
Buy or subscribe

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Old, L. J. Science 230, 630–632 (1985).

    Article  ADS  CAS  Google Scholar 

  2. Beutler, B. & Cerami, A. Adv. Immun. 42, 213–231 (1988).

    Article  CAS  Google Scholar 

  3. Goeddel, D. V. et al. Cold Spring Harb. Symp. quant. Biol. 51, 597–609 (1986).

    Article  CAS  Google Scholar 

  4. Young, J. D.-E., Liu, C.-C., Butler, G., Cohn, Z. A. & Galli, S. J. Proc. natn. Acad. Sci. U.S.A. 84, 9175–9179 (1987).

    Article  ADS  CAS  Google Scholar 

  5. Richards, A. L., Okuno, T., Takagaki, Y. & Djeu, J. Y. J. Immun. 141, 3061–3066 (1988).

    CAS  PubMed  Google Scholar 

  6. Steffen, M., Abboud, M., Potter, G. K., Yung, Y. P. & Moore, M. A. S. Immunology 66, 445–450 (1989).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Ishizaka, T. in Allergy, Principles and Practice, 3rd edn (eds Middleton, Jr. E., Reed, C. E., Ellis, E. F., Adkinson, Jr. N. F. & Yunginger, J. W.) 71–93 (Mosby, St Louis, 1988).

    Google Scholar 

  8. Nabel, G., Galli, S. J., Dvorak, A. M., Dvorak, H. F. & Cantor, H. Nature 291, 332–334 (1981).

    Article  ADS  CAS  Google Scholar 

  9. Galli, S. J. et al. J. Cell Biol. 95, 435–444 (1982).

    Article  CAS  Google Scholar 

  10. Galli, S. J. Lab. Invest 62, 5–33 (1990).

    CAS  PubMed  Google Scholar 

  11. Semon, D., Kawashima, E., Jongeneel, C. V., Shakhov, A. N. & Nedospasov, S. A. Nucleic Acids Res. 15, 9083–9084 (1987).

    Article  CAS  Google Scholar 

  12. Plaut, M. et al. Nature 339, 64–67 (1989).

    Article  ADS  CAS  Google Scholar 

  13. Burd, P. et al. J. exp. Med. 170, 245–257 (1989).

    Article  CAS  Google Scholar 

  14. Wodnar-Filipowicz, A., Heusser, C. H. & Moroni, C. Nature 339, 150–152 (1989).

    Article  ADS  CAS  Google Scholar 

  15. Cuturi, M. C. et al. J. exp. Med. 165, 1581–1594 (1987).

    Article  CAS  Google Scholar 

  16. Sung, S.-S. J. et al. J. exp. Med. 168, 1539–1551 (1988).

    Article  CAS  Google Scholar 

  17. Gamble, J. R., Harlan, J. M., Klebanoff, S. J. & Vadas, M. A. Proc. natn. Acad. Sci. U.S.A 82, 8667–8671 (1985).

    Article  ADS  CAS  Google Scholar 

  18. Pober, J. S. et al. J. Immun. 137, 1893–1896 (1986).

    CAS  PubMed  Google Scholar 

  19. Tracey, K. J. et al. J. exp. Med. 167, 1211–1227 (1988).

    Article  CAS  Google Scholar 

  20. Rampart, M., DeSmet, W., Fiers, W. & Herman, A. G. J. exp. Med. 169, 2227–2232 (1989).

    Article  CAS  Google Scholar 

  21. Askenase, P. W. Springer Semin. Immunopathol. 2, 417–442 (1980).

    Article  Google Scholar 

  22. Lichtenstein, L. M. J. Allergy clin. Immun. 81, 814–820 (1988).

    Article  CAS  Google Scholar 

  23. Galli, S. J., Wang, Z.-S., Gordon, J. R. & Wershil, B. K. FASEB J. 4, A1875 (1990).

    Google Scholar 

  24. Leibovich, S. J. et al. Nature 329, 630–632 (1987).

    Article  ADS  CAS  Google Scholar 

  25. Selye, H. The Mast Cells (Butterworths, Washington, DC, 1965).

    Google Scholar 

  26. Starkey, J. R., Crowle, P. K. & Taubenberger, S. Int. J. Cancer 42, 48–52 (1988).

    Article  CAS  Google Scholar 

  27. Pennica, D. et al. Proc. natn. Acad. Sci. U.S.A. 82, 6060–6064 (1985).

    Article  ADS  CAS  Google Scholar 

  28. Liu, F.-T. et al. J. Immun. 124, 2728–2737 (1980).

    CAS  Google Scholar 

  29. Johnston, P. A., Jansen, M. M., Somers, S. D., Adams, D. O. & Hamilton, T. A. J. Immun. 138, 1551–1558 (1987).

    CAS  PubMed  Google Scholar 

  30. Green, L. M., Reade, J. L. & Ware, C. F. J. immunol. Meth. 70, 257–268 (1984).

    Article  CAS  Google Scholar 

  31. Davis, L. G., Dibner, M. D. & Battey, J. F. Basic Methods in Molecular Biology (Elsevier, New York, 1986).

    Google Scholar 

  32. Cleveland, D. W. et al. Cell 20, 95–105 (1980).

    Article  CAS  Google Scholar 

  33. Chomczynski, P. & Sacchi, N. Analyt. Biochem. 162, 156–159 (1987).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Pathology, Beth Israel Hospital and Harvard Medical School, and the Division of Experimental Pathology, Beth Israel Hospital, Boston, Massachusetts, 02215, USA

    John R. Gordon & Stephen J. Galli

Authors
  1. John R. Gordon
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stephen J. Galli
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gordon, J., Galli, S. Mast cells as a source of both preformed and immunologically inducible TNF-α/cachectin. Nature 346, 274–276 (1990). https://doi.org/10.1038/346274a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/346274a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing