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Gap Junctions Couple Astrocytes and Oligodendrocytes

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Abstract

In vertebrates, a family of related proteins called connexins form gap junctions (GJs), which are intercellular channels. In the central nervous system (CNS), GJs couple oligodendrocytes and astrocytes (O/A junctions) and adjacent astrocytes (A/A junctions), but not adjacent oligodendrocytes, forming a “glial syncytium.” Oligodendrocytes and astrocytes each express different connexins. Mutations of these connexin genes demonstrate that the proper functioning of myelin and oligodendrocytes requires the expression of these connexins. The physiological function of O/A and A/A junctions, however, remains to be illuminated.

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Acknowledgment

This work was supported by the National Multiple Sclerosis Society and the following NIH grants: NS054363 (to J.L.O.-M.), NS55284 and NS043560 (to S.S.S.), and NS50345 and NS050705 (to C.K.A.). We thank Dr. Bruce Altevogt, Dr. Michael Bennett, Dr. Kleopas Kleopa, Dr. Michael Koval, Dr. Daniela Menichella, Dr. David Paul, and Dr. Sabrina Yum for their many informative discussions.

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  1. Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

    Jennifer L. Orthmann-Murphy & Steven S. Scherer

  2. Department of Neurology, SUNY Downstate Medical Center, Brooklyn, NY, USA

    Charles K. Abrams

  3. University of Pennsylvania Medical Center, Room 464 Stemmler Hall, 3450 Hamilton Walk, Philadelphia, PA, 19104-6077, USA

    Jennifer L. Orthmann-Murphy

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Correspondence to Jennifer L. Orthmann-Murphy.

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Orthmann-Murphy, J.L., Abrams, C.K. & Scherer, S.S. Gap Junctions Couple Astrocytes and Oligodendrocytes. J Mol Neurosci 35, 101–116 (2008). https://doi.org/10.1007/s12031-007-9027-5

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