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Neurogenesis in the adult hippocampus

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Abstract

New neurons continue to be generated in two privileged areas of the adult brain: the dentate gyrus of the hippocampal formation and the olfactory bulb. Adult neurogenesis has been found in all mammals studied to date, including humans. The process of adult neurogenesis encompasses the proliferation of resident neural stem and progenitor cells and their subsequent differentiation, migration, and functional integration into the pre-existing circuitry. This article summarizes recent findings regarding the developmental steps involved in adult hippocampal neurogenesis and the possible functional roles that new hippocampal neurons might play.

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Authors and Affiliations

  1. Departments of Neurobiology, Psychology, and Psychiatry and the Brain Research Institute, University of California, Los Angeles, 695 Charles Young Drive South, Los Angeles, CA 90095–1761, USA

    Dan Ehninger

  2. Center for Regenerative Therapies Dresden, Am Tatzberg 47–49, 01307, Dresden, Germany

    Gerd Kempermann

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  1. Dan Ehninger
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Correspondence to Dan Ehninger.

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Ehninger, D., Kempermann, G. Neurogenesis in the adult hippocampus. Cell Tissue Res 331, 243–250 (2008). https://doi.org/10.1007/s00441-007-0478-3

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