Graphs are widely used to model complex data in many applications, such as bioinformatics, chemistry, social networks, pattern recognition, etc. A fundamental and critical query primitive is to efficiently search similar structures in a large collection of graphs. This paper studies the graph similarity queries with edit distance constraints. Existing solutions to the problem utilize fixed-size overlapping substructures to generate candidates, and thus become susceptible to large vertex degrees or large distance thresholds. In this paper, we present a partition-based approach to tackle the problem. By dividing data graphs into variable-size non-overlapping partitions, the edit distance constraint is converted to a graph containment constraint for candidate generation. We develop efficient query processing algorithms based on the new paradigm. A candidate pruning technique and an improved graph edit distance algorithm are also developed to further boost the performance. In addition, a cost-aware graph partitioning technique is devised to optimize the index. Extensive experiments demonstrate our approach significantly outperforms existing approaches.