Objective: To investigate the influence of pregnancy on patients with neuromyelitis optica
spectrum disorder (NMOSD). Methods: A total of 190 women with NMOSD were enrolled from …

Objective To evaluate the efficacy and safety of repeated rituximab treatment based on the
assessment of peripheral circulating memory B cells over 24 months in patients with relapsing …

Background: Although neuromyelitis optica has been traditionally regarded as a disease
without brain involvement, brain abnormalities are not uncommon in patients with neuromyelitis …

Objectives: Recent case reports and series have shown that patients with neuromyelitis
optica (NMO) experience clinical deterioration under interferon beta (IFN-β) treatment. The …

Background: Although brain abnormalities are being recognized more frequently in patients
with neuromyelitis optica spectrum disorder (NMOSD), most brain lesions in previous …

For systemically delivered nanoparticles to reach target tissues, they must first circulate long
enough to reach the target and extravasate there. A challenge is that the particles end up …

Neuromyelitis optica (NMO) is an idiopathic inflammatory syndrome of the central nervous
system that is characterized by severe attacks of optic neuritis (ON) and myelitis. Until recently, …

Objective: To evaluate the efficacy and safety of mitoxantrone hydrochloride and determine
how it exhibits a differential inhibitory effect on subsets of B cells in patients with highly …

Background and Purpose Although plasmapheresis is becoming standard practice as a
rescue therapy for neuromyelitis optica (NMO), evidence for the therapeutic efficacy of …

In this paper, we consider cooperative multi-agent reinforcement learning (MARL) with sparse
reward. To tackle this problem, we propose a novel method named MASER: MARL with …