Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
…, SP Winter, H Ireland-Zecchini, S Reichelt, WJ Howat… - Science, 2009 - science.org
Pancreatic ductal adenocarcinoma (PDA) is among the most lethal human cancers in part
because it is insensitive to many chemotherapeutic drugs. Studying a mouse model of PDA …
because it is insensitive to many chemotherapeutic drugs. Studying a mouse model of PDA …
[HTML][HTML] Tissue fixation and the effect of molecular fixatives on downstream staining procedures
WJ Howat, BA Wilson - Methods, 2014 - Elsevier
It is impossible to underplay the importance of fixation in histopathology. Whether the scientist
is interested in the extraction of information on lipids, proteins, RNA or DNA, fixation is …
is interested in the extraction of information on lipids, proteins, RNA or DNA, fixation is …
Regulation of ERBB2 by oestrogen receptor–PAX2 determines response to tamoxifen
Crosstalk between the oestrogen receptor (ER) and ERBB2/HER-2 pathways has long been
implicated in breast cancer aetiology and drug response 1 , yet no direct connection at a …
implicated in breast cancer aetiology and drug response 1 , yet no direct connection at a …
High numbers of tumor-infiltrating programmed cell death 1–positive regulatory lymphocytes are associated with improved overall survival in follicular lymphoma
Purpose Tumor microenvironment influences the behavior of follicular lymphoma (FL),
although the specific cell subsets involved are not well known. The aim of this study was to …
although the specific cell subsets involved are not well known. The aim of this study was to …
Application of phage display to high throughput antibody generation and characterization
…, MR Dyson, G Flack, GJ Griffin, Y Hooks, WJ Howat… - Genome biology, 2007 - Springer
We have created a high quality phage display library containing over 10 10 human antibodies
and describe its use in the generation of antibodies on an unprecedented scale. We have …
and describe its use in the generation of antibodies on an unprecedented scale. We have …
Elevated levels of G-quadruplex formation in human stomach and liver cancer tissues
Four-stranded G-quadruplex DNA secondary structures have recently been visualized in the
nuclei of human cultured cells. Here, we show that BG4, a G-quadruplex-specific antibody, …
nuclei of human cultured cells. Here, we show that BG4, a G-quadruplex-specific antibody, …
SPARC independent drug delivery and antitumour effects of nab-paclitaxel in genetically engineered mice
A Neesse, KK Frese, DS Chan, TE Bapiro, WJ Howat… - Gut, 2014 - gut.bmj.com
Design Pharmacokinetic and pharmacodynamic parameters of cremophor-paclitaxel, nab-paclitaxel
(human-albumin-bound paclitaxel, Abraxane) and a novel mouse-albumin-bound …
(human-albumin-bound paclitaxel, Abraxane) and a novel mouse-albumin-bound …
[HTML][HTML] Antibody validation of immunohistochemistry for biomarker discovery: recommendations of a consortium of academic and pharmaceutical based …
As biomarker discovery takes centre-stage, the role of immunohistochemistry within that
process is increasing. At the same time, the number of antibodies being produced for “research …
process is increasing. At the same time, the number of antibodies being produced for “research …
MRI with hyperpolarised [1-13C] pyruvate detects advanced pancreatic preneoplasia prior to invasive disease in a mouse model
Objectives Pancreatic cancer (PCa) is treatable by surgery when detected at an early stage.
Non-invasive imaging methods able to detect both established tumours and their precursor …
Non-invasive imaging methods able to detect both established tumours and their precursor …
Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma
…, JL Miller, SS Rao, T Demuth, WJ Howat… - Journal of Experimental …, 2012 - rupress.org
RESULTS AND DISCUSSION The Notch pathway is activated in human and mouse PDA and
can be inhibited by a GSI Consistent with prior studies (Hingorani et al., 2003; Miyamoto et …
can be inhibited by a GSI Consistent with prior studies (Hingorani et al., 2003; Miyamoto et …