Background The full complement of DNA mutations that are responsible for the pathogenesis
of acute myeloid leukemia (AML) is not yet known. Methods We used massively parallel …

Most patients with acute myeloid leukaemia (AML) die from progressive disease after relapse,
which is associated with clonal evolution at the cytogenetic level 1 , 2 . To determine the …

Background The genetic alterations responsible for an adverse outcome in most patients
with acute myeloid leukemia (AML) are unknown. Methods Using massively parallel DNA …

Most mutations in cancer genomes are thought to be acquired after the initiating event,
which may cause genomic instability and drive clonal evolution. However, for acute myeloid …

Acute myeloid leukaemia is a highly malignant haematopoietic tumour that affects about
13,000 adults in the United States each year. The treatment of this disease has changed little in …

In the weeks after birth, the gut acquires a nascent microbiome, and starts its transition to
bacterial population equilibrium. This early-in-life microbial population quite likely influences …

Background Gut bacteria might predispose to or protect from necrotising enterocolitis, a severe
illness linked to prematurity. In this observational prospective study we aimed to assess …

A current controversy is whether patients with sepsis progress to an immunosuppressed
state. We hypothesized that reactivation of latent viruses occurred with prolonged sepsis …

This paper presents new biostatistical methods for the analysis of microbiome data based on
a fully parametric approach using all the data. The Dirichlet-multinomial distribution allows …

Regulatory T cells (Tregs) suppress graft-versus-host disease (GVHD) while preserving a
beneficial graft-versus-leukemia (GVL) effect. Thus, their use in allogeneic stem cell …