Lenvatinib targets FGF receptor 4 to enhance antitumor immune response of anti–programmed cell death‐1 in HCC

…, L Liu, W Shao, R Zhang, J Lin, J Zhang, W Zhu… - …, 2021 - Wiley Online Library
Background and Aims Recently, clinical trials of lenvatinib plus pembrolizumab in HCC have
displayed an impressive objective response rate. This study aimed to clarify the mechanism …

[PDF][PDF] Acetylation of PGK1 promotes liver cancer cell proliferation and tumorigenesis

H Hu, W Zhu, J Qin, M Chen, L Gong, L Li, X Liu… - …, 2017 - Wiley Online Library
Phosphoglycerate kinase 1 (PGK1) is an important enzyme in the metabolic glycolysis
pathway. In this study, we observed a significant overexpression of PGK1 in liver cancer tissues …

Machine learning-based quantitative texture analysis of CT images of small renal masses: differentiation of angiomyolipoma without visible fat from renal cell …

Z Feng, P Rong, P Cao, Q Zhou, W Zhu, Z Yan, Q Liu… - European …, 2018 - Springer
Objective To evaluate the diagnostic performance of machine-learning based quantitative
texture analysis of CT images to differentiate small (≤ 4 cm) angiomyolipoma without visible …

Research on the orderly charging and discharging mechanism of electric vehicles considering travel characteristics and carbon quota

L Zhang, Q Yin, W Zhu, L Lyu, L Jiang… - IEEE Transactions …, 2023 - ieeexplore.ieee.org
To study the impact of personal carbon trading (PCT) mechanism on the economy and reliability
of the power distribution system operation, this paper proposes an orderly charging and …

GOLM1 exacerbates CD8+ T cell suppression in hepatocellular carcinoma by promoting exosomal PD-L1 transport into tumor-associated macrophages

…, Z Lin, L Liu, R Zhang, Y Geng, M Fan, W Zhu… - … and Targeted Therapy, 2021 - nature.com
The immunosuppressive microenvironment plays an important role in tumor progression
and immunotherapy responses. Golgi membrane protein 1 (GOLM1) is correlated to …

68Ga-FAPI-04 Versus 18F-FDG PET/CT in the Detection of Hepatocellular Carcinoma

H Wang, W Zhu, S Ren, Y Kong, Q Huang… - Frontiers in …, 2021 - frontiersin.org
Background Fibroblast activation protein (FAP) is commonly expressed in activated stromal
fibroblasts in various epithelial tumours. Recently, 68 Ga-FAPI-04 has been used for tumour …

Elevated G6PD expression contributes to migration and invasion of hepatocellular carcinoma cells by inducing epithelial-mesenchymal transition

…, G Yu, J Chen, L Qin, L Wang, W Zhu… - Acta biochimica et …, 2018 - academic.oup.com
Altered metabolism is one of the hallmarks of cancer cells. Pentose phosphate pathway (PPP)
is a fundamental component of cellular metabolism. Glucose-6-phosphate …

AADAC protects colorectal cancer liver colonization from ferroptosis through SLC7A11-dependent inhibition of lipid peroxidation

…, M Huo, R Zhang, J Lin, C Xiao, Y Li, W Zhu… - Journal of Experimental …, 2022 - Springer
Background Oxidative stress is a highly active metabolic process in the liver, that poses great
threats to disseminated tumor cells during their colonization. Here, we aimed to investigate …

Characteristics of pre-metastatic niche: the landscape of molecular and cellular pathways

…, JC Jacob, Y Zheng, C Gao, S Wang, W Zhu… - Molecular …, 2021 - Springer
Metastasis is a major contributor to cancer-associated deaths. It involves complex interactions
between primary tumorigenic sites and future metastatic sites. Accumulation studies have …

LSD1 sustains pancreatic cancer growth via maintaining HIF1α-dependent glycolytic process

Y Qin, W Zhu, W Xu, B Zhang, S Shi, S Ji, J Liu, J Long… - Cancer letters, 2014 - Elsevier
The histone demethylase LSD1 (lysine specific demethylase 1) plays an important role in
the epigenetic regulation of gene transcription. Our study investigated the role of LSD1 in …