Amplicon-based next-generation sequencing (NGS) of immunoglobulin (IG) and T-cell
receptor (TR) gene rearrangements for clonality assessment, marker identification and …

Motivation The study of immunoglobulins and T cell receptors using next-generation
sequencing has finally allowed exploring immune repertoires and responses in their immense …

One of the hallmarks of B lymphoid malignancies is a B cell clone characterized by a unique
footprint of clonal immunoglobulin (IG) gene rearrangements that serves as a diagnostic …

Assessment of clonality, marker identification and measurement of minimal residual disease
(MRD) of immunoglobulin (IG) and T cell receptor (TR) gene rearrangements in lymphoid …

Ig gene (IG) clonality analysis has an important role in the distinction of benign and malignant
B-cell lymphoid proliferations and is mostly performed with the conventional EuroClonality/…

Allogeneic stem cell transplantation (alloSCT) is used for treating patients with T-prolymphocytic
leukemia (T-PLL). However, direct evidence of GvL activity in T-PLL is lacking. We …

B-cell neoplasms represent a clinically heterogeneous group of hematologic malignancies
with considerably diverse genomic architecture recently endorsed by next-generation …

The ontogeny of the natural, public IgM repertoire remains incompletely explored. Here, high-resolution
immunogenetic analysis of B cells from (unrelated) fetal, child, and adult samples…

Motivation Sanger sequencing is still being employed for sequence variant detection by many
laboratories, especially in a clinical setting. However, chromatogram interpretation often …

V moji bakalářské práci se věnuji výpočetnímu algoritmu MSMAD (Budinská et al., 2009)
určenému k analýze dat z array CGH mikročipů. Tato metoda implementovaná jako funkce v …