User profiles for Tom Chen

Tom T. Chen - Verified email at gene.com - Cited by 5460
Dr Tom Chen - Verified email at kent.ac.uk - Cited by 3652

Autocrine VEGF signaling is required for vascular homeostasis

S Lee, TT Chen, CL Barber, MC Jordan, J Murdock… - Cell, 2007 - cell.com
Vascular endothelial growth factor (VEGF) is essential for developmental and pathological
angiogenesis. Here we show that in the absence of any pathological insult, autocrine VEGF is …

B cells are associated with survival and immunotherapy response in sarcoma

F Petitprez, A de Reyniès, EZ Keung, TWW Chen… - Nature, 2020 - nature.com
Soft-tissue sarcomas represent a heterogeneous group of cancer, with more than 50
histological subtypes 1 , 2 . The clinical presentation of patients with different subtypes is often …

SD logic–informed customer engagement: integrative framework, revised fundamental propositions, and application to CRM

LD Hollebeek, RK Srivastava, T Chen - Journal of the Academy of …, 2019 - Springer
Research addressing the micro-foundational theoretical entity of customer engagement (CE)
has proliferated in recent years. In parallel, the macro-foundational theory of service-…

Exploring positively-versus negatively-valenced brand engagement: a conceptual model

LD Hollebeek, T Chen - Journal of Product & Brand Management, 2014 - emerald.com
Purpose After gaining traction in business practice the “brand engagement”(BE) concept has
transpired in the academic marketing/branding literature. BE has been defined as the level …

Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells

TT Chen, A Luque, S Lee, SM Anderson… - Journal of cell …, 2010 - rupress.org
VEGF can be secreted in multiple isoforms with variable affinity for extracellular proteins and
different abilities to induce vascular morphogenesis, but the molecular mechanisms behind …

[BOOK][B] The electronics handbook

…, I Buchmann, JA Chambers, C Chan, T Chen… - 2018 - taylorfrancis.com
During the ten years since the appearance of the groundbreaking, bestselling first edition of
The Electronics Handbook, the field has grown and changed tremendously. With a focus on …

Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis

RG Knodell, KG Ishak, WC Black, TS Chen, R Craig… - Hepatology, 1981 - journals.lww.com
A Histology Activity Index has been developed which generates a numerical score for liver
biopsy specimens obtained from patients with asymptomatic chronic active hepatitis. Biopsies …

GDF-8 propeptide binds to GDF-8 and antagonizes biological activity by inhibiting GDF-8 receptor binding

RS Tries, T Chen, MV Da Vies, KN Tomkinson… - Growth …, 2001 - Taylor & Francis
GDF-8 is a new member of the TGF-β superfamily which appears to be a negative regulator
of skeletal muscle mass. Factors which regulate the biological activity of GDF-8 have not yet …

Customer engagement behaviors: The role of service convenience, fairness and quality

SK Roy, V Shekhar, WM Lassar, T Chen - Journal of Retailing and …, 2018 - Elsevier
The purpose of this study is to examine the differential impact of service quality, service fairness
and service convenience on customer engagement behaviors. The study also examines …

Nanoparticle biointerfacing by platelet membrane cloaking

…, V Qu, SH Patel, J Zhu, W Shi, FM Hofman, TC Chen… - Nature, 2015 - nature.com
Abstract Development of functional nanoparticles can be encumbered by unanticipated material
properties and biological events, which can affect nanoparticle effectiveness in complex…