Primary pulmonary alveolar proteinosis (PAP) is a rare syndrome characterized by accumulation
of surfactant in the lungs that is presumed to be mediated by disruption of granulocyte/…

Bone-marrow transplantation is an effective cell therapy but requires myeloablation, which
increases infection risk and mortality. Recent lineage-tracing studies documenting that …

Gut dysbiosis caused by antibiotics impairs response to immune checkpoint blockade (ICB).
Gut microbiota is becoming an attractive therapeutic target for cancer. The Clostridium …

To the Editor: Idiopathic pulmonary alveolar proteinosis is a rare disease in which surfactant
lipids and proteins accumulate in pulmonary alveolar macrophages and alveoli, resulting in …

Rationale: We identified a 6-year-old girl with pulmonary alveolar proteinosis (PAP), impaired
granulocyte-macrophage colony–stimulating factor (GM-CSF) receptor function, and …

Introduction The emergence of SARS‐CoV‐2 has caused global public health and
economic crisis. Human leukocyte antigen (HLA) is a critical component of the viral antigen …

Background Pulmonary alveolar proteinosis is a disease characterized by abnormal
accumulation of surfactant in the alveoli. Most cases are autoimmune and are associated with an …

Clinical success of immune-checkpoint blockade (ICB) cancer immunotherapy is compromised
by increased risk of immune-related adverse events (irAEs). However, mechanistic action…

Oral microbiota is associated with human diseases including cancer. Emerging evidence
suggests that proton pump inhibitors (PPIs), which allow the oral microbiome to translocate into …

Autoantibodies against granulocyte/macrophage colony-stimulating factor (GMAbs) cause
autoimmune pulmonary alveolar proteinosis (PAP) and measurement of the GMAb level in …