Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen–specific T-cell immunity in head and neck cancer patients

RM Srivastava, SC Lee, PA Andrade Filho… - Clinical Cancer …, 2013 - AACR
Purpose: Tumor antigen–specific monoclonal antibodies (mAb) block oncogenic signaling
and induce Fcγ receptor (FcγR)–mediated cytotoxicity. However, the role of CD8 + CTL and …

CTLA-4+ Regulatory T Cells Increased in Cetuximab-Treated Head and Neck Cancer Patients Suppress NK Cell Cytotoxicity and Correlate with Poor Prognosis

HB Jie, PJ Schuler, SC Lee, RM Srivastava, A Argiris… - Cancer research, 2015 - AACR
The EGFR-targeted antibody cetuximab is effective against head and neck cancer (HNSCC),
but in only 15% to 20% of patients, and the variability and extent of cetuximab-mediated …

Natural killer (NK): dendritic cell (DC) cross talk induced by therapeutic monoclonal antibody triggers tumor antigen-specific T cell immunity

SC Lee, RM Srivastava, A López-Albaitero… - Immunologic …, 2011 - Springer
Tumor antigen (TA)-targeted monoclonal antibodies (mAb), trastuzumab, cetuximab,
panitumumab, and rituximab, have been among the most successful new therapies in the present …

Role of polymorphic Fc gamma receptor IIIa and EGFR expression level in cetuximab mediated, NK cell dependent in vitro cytotoxicity of head and neck squamous …

A López-Albaitero, SC Lee, S Morgan… - Cancer immunology …, 2009 - Springer
Immunotherapy with the EGFR-specific mAb cetuximab is clinically effective in 10–20% of
patients with squamous cell carcinoma of the head and neck (SCCHN). Little information is …

Thyroid carcinoma: phenotypic features, underlying biology and potential relevance for targeting therapy

J Hu, IJ Yuan, S Mirshahidi, A Simental, SC Lee… - International journal of …, 2021 - mdpi.com
Thyroid carcinoma consists a group of phenotypically heterogeneous cancers. Recent advances
in biological technologies have been advancing the delineation of genetic, epigenetic, …

Death pathways in noise-damaged outer hair cells

BA Bohne, GW Harding, SC Lee - Hearing research, 2007 - Elsevier
Using morphological criteria, death pathways in outer hair cells (OHCs) were determined in
chinchilla organs of Corti that had been exposed to a high- or moderate-level octave band of …

[HTML][HTML] Endoscopic skull base surgery

SC Lee, BA Senior - Clinical and experimental …, 2008 - synapse.koreamed.org
… This series was limited to patients with Kadish A and B disease with the author's current
preference for open craniofacial resection for Kadish C diease. Another report on 18 patients …

Diagnostic and management applications of ChatGPT in structured otolaryngology clinical scenarios

RW Qu, U Qureshi, G Petersen, SC Lee - OTO open, 2023 - Wiley Online Library
Objective To evaluate the clinical applications and limitations of chat generative pretrained
transformer (ChatGPT) in otolaryngology. Study Design Cross‐sectional survey. Setting …

Cancer stem cell self-renewal as a therapeutic target in human oral cancer

J Hu, S Mirshahidi, A Simental, SC Lee… - Oncogene, 2019 - nature.com
Tumor recurrence following treatment remains a major clinical challenge in oral cavity
cancer. Cancer stem cells (CSCs) have been isolated from human oral cancers and been …

Serum biomarkers as potential predictors of antitumor activity of cetuximab-containing therapy for locally advanced head and neck cancer

A Argiris, SC Lee, T Feinstein, S Thomas… - Oral oncology, 2011 - Elsevier
We sought to identify biomarkers of antitumor activity in patients with locally advanced head
and neck cancer treated with therapy containing cetuximab, an epidermal growth factor …