Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen–specific T-cell immunity in head and neck cancer patients
RM Srivastava, SC Lee, PA Andrade Filho… - Clinical Cancer …, 2013 - AACR
Purpose: Tumor antigen–specific monoclonal antibodies (mAb) block oncogenic signaling
and induce Fcγ receptor (FcγR)–mediated cytotoxicity. However, the role of CD8 + CTL and …
and induce Fcγ receptor (FcγR)–mediated cytotoxicity. However, the role of CD8 + CTL and …
CTLA-4+ Regulatory T Cells Increased in Cetuximab-Treated Head and Neck Cancer Patients Suppress NK Cell Cytotoxicity and Correlate with Poor Prognosis
The EGFR-targeted antibody cetuximab is effective against head and neck cancer (HNSCC),
but in only 15% to 20% of patients, and the variability and extent of cetuximab-mediated …
but in only 15% to 20% of patients, and the variability and extent of cetuximab-mediated …
Natural killer (NK): dendritic cell (DC) cross talk induced by therapeutic monoclonal antibody triggers tumor antigen-specific T cell immunity
SC Lee, RM Srivastava, A López-Albaitero… - Immunologic …, 2011 - Springer
Tumor antigen (TA)-targeted monoclonal antibodies (mAb), trastuzumab, cetuximab,
panitumumab, and rituximab, have been among the most successful new therapies in the present …
panitumumab, and rituximab, have been among the most successful new therapies in the present …
Role of polymorphic Fc gamma receptor IIIa and EGFR expression level in cetuximab mediated, NK cell dependent in vitro cytotoxicity of head and neck squamous …
A López-Albaitero, SC Lee, S Morgan… - Cancer immunology …, 2009 - Springer
Immunotherapy with the EGFR-specific mAb cetuximab is clinically effective in 10–20% of
patients with squamous cell carcinoma of the head and neck (SCCHN). Little information is …
patients with squamous cell carcinoma of the head and neck (SCCHN). Little information is …
Thyroid carcinoma: phenotypic features, underlying biology and potential relevance for targeting therapy
J Hu, IJ Yuan, S Mirshahidi, A Simental, SC Lee… - International journal of …, 2021 - mdpi.com
Thyroid carcinoma consists a group of phenotypically heterogeneous cancers. Recent advances
in biological technologies have been advancing the delineation of genetic, epigenetic, …
in biological technologies have been advancing the delineation of genetic, epigenetic, …
Death pathways in noise-damaged outer hair cells
BA Bohne, GW Harding, SC Lee - Hearing research, 2007 - Elsevier
Using morphological criteria, death pathways in outer hair cells (OHCs) were determined in
chinchilla organs of Corti that had been exposed to a high- or moderate-level octave band of …
chinchilla organs of Corti that had been exposed to a high- or moderate-level octave band of …
[HTML][HTML] Endoscopic skull base surgery
SC Lee, BA Senior - Clinical and experimental …, 2008 - synapse.koreamed.org
… This series was limited to patients with Kadish A and B disease with the author's current
preference for open craniofacial resection for Kadish C diease. Another report on 18 patients …
preference for open craniofacial resection for Kadish C diease. Another report on 18 patients …
Diagnostic and management applications of ChatGPT in structured otolaryngology clinical scenarios
RW Qu, U Qureshi, G Petersen, SC Lee - OTO open, 2023 - Wiley Online Library
Objective To evaluate the clinical applications and limitations of chat generative pretrained
transformer (ChatGPT) in otolaryngology. Study Design Cross‐sectional survey. Setting …
transformer (ChatGPT) in otolaryngology. Study Design Cross‐sectional survey. Setting …
Cancer stem cell self-renewal as a therapeutic target in human oral cancer
J Hu, S Mirshahidi, A Simental, SC Lee… - Oncogene, 2019 - nature.com
Tumor recurrence following treatment remains a major clinical challenge in oral cavity
cancer. Cancer stem cells (CSCs) have been isolated from human oral cancers and been …
cancer. Cancer stem cells (CSCs) have been isolated from human oral cancers and been …
Serum biomarkers as potential predictors of antitumor activity of cetuximab-containing therapy for locally advanced head and neck cancer
We sought to identify biomarkers of antitumor activity in patients with locally advanced head
and neck cancer treated with therapy containing cetuximab, an epidermal growth factor …
and neck cancer treated with therapy containing cetuximab, an epidermal growth factor …