A summary is given of a report that had the following goals: to describe computer science in
a way that emphasizes fundamental questions and significant accomplishments; to propose …

Infection with any 1 of 4 dengue viruses produces a spectrum of clinical illness ranging from
a mild undifferentiated febrile illness to dengue fever (DF) to dengue hemorrhagic fever (…

We describe the development of a capture enzyme-linked immunosorbent assay for the
detection of the dengue virus nonstructural protein NS1. The assay employs rabbit polyclonal …

Antibodies protect against homologous Dengue virus (DENV) infection but can precipitate
severe dengue by promoting heterotypic virus entry via Fcγ receptors (FcγR). We immortalized …

Although many workers have investigated the maturation and processing of the flavivirus
nonstructural glycoprotein NS1 in infected cells, these studies have provided little insight into a …

The flavivirus nonstructural glycoprotein NS1 is an enigmatic protein whose structure and
mechanistic function have remained somewhat elusive ever since it was first reported in 1970 …

Complications arising from dengue virus infection include potentially fatal vascular leak, and
severe disease has been linked with excessive immune cell activation. An understanding of …

Infection with any of the 4 dengue virus serotypes results in a diverse range of symptoms,
from mild undifferentiated fever to life-threatening hemorrhagic fever and shock. Given that …

Endogenous retroviruses are a common ancestral feature of mammalian genomes with most
having been inactivated over time through mutation and deletion 1 . A group of more intact …

Recombinant forms of the dengue 2 virus NS3 protease linked to a 40-residue co-factor,
corresponding to part of NS2B, have been expressed in Escherichia coli and shown to be active …