RNA abundance is a powerful indicator of the state of individual cells. Single-cell RNA
sequencing can reveal RNA abundance with high quantitative accuracy, sensitivity and …

The regulated transcription of genes determines cell identity and function. Recent structural
studies have elucidated mechanisms that govern the regulation of transcription by RNA …

Structures of a 10-subunit yeast RNA polymerase II have been derived from two crystal forms
at 2.8 and 3.1 angstrom resolution. Comparison of the structures reveals a division of the …

The new coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses
an RNA-dependent RNA polymerase (RdRp) for the replication of its genome and the …

A backbone model of a 10-subunit yeast RNA polymerase II has been derived from x-ray
diffraction data extending to 3 angstroms resolution. All 10 subunits exhibit a high degree of …

The crystal structure of RNA polymerase II in the act of transcription was determined at 3.3 Å
resolution. Duplex DNA is seen entering the main cleft of the enzyme and unwinding before …

Integrator and protein phosphatase 2A (PP2A) form a complex that dephosphorylates paused
RNA polymerase II (Pol II), cleaves the nascent RNA, and terminates transcription. We …

Gene regulation involves activation of RNA polymerase II (Pol II) that is paused and bound
by the protein complexes DRB sensitivity-inducing factor (DSIF) and negative elongation …

To the Editor—AlphaFold2 is a machine-learning algorithm for protein structure prediction
that has now been used to obtain hundreds of thousands of protein models. The resulting …

The eukaryotic RNA polymerases Pol I, Pol II, and Pol III are the central multiprotein machines
that synthesize ribosomal, messenger, and transfer RNA, respectively. Here we provide a …