Context: It is unclear whether patients with asymptomatic primary hyperparathyroidism (PHPT)
do better with parathyroidectomy (PTx) as compared with conservative medical …

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy is a rare autosomal
recessive disorder characterized by hypoparathyroidism, adrenal failure, chronic …

We investigated the involvement of the HRPT2 gene by loss of heterozygosity analysis and
direct sequencing in a kindred with hyperparathyroidism-jaw tumor syndrome (HPT-JT) and …

Background The Italian Society for Orthopaedics and Traumatology conceived this guidance—which
is primarily addressed to Italian orthopedic surgeons, but should also prove useful …

Calcium is an essential element that plays numerous biological functions in the human body,
of which one of the most important is skeleton mineralization. Bone is a mineralized …

Context: An increased risk of fracture in patients with primary hyperparathyroidism (PHPT)
compared to the general population has been reported, but available data are controversial. …

In the recent years, both the prescriptions of serum 25(OH)D levels assay, and vitamin D
supplementation are constantly increasing, as well as the costs to be incurred relating to these …

Muscle and bone are anatomically and functionally closely connected. The traditional concept
that skeletal muscles serve to load bone and transform skeletal segments into a system of …

The major physiological role of the vitamin D receptor (VDR) is the maintenance of mineral
ion homeostasis. Mutation of the VDR, in humans and mice, results in alopecia. Unlike the …

Osteoporotic fractures are one of the major causes of increased morbidity and mortality in
postmenopausal women and the overall aging population. One of the major issues in the …