CDK4/6 inhibition enhances oncolytic virus efficacy by potentiating tumor-selective cell killing and T-cell activation in refractory glioblastoma

J Xiao, J Liang, J Fan, P Hou, X Li, H Zhang, K Li, L Bu… - Cancer Research, 2022 - AACR
… Qiaoqiao Xiao; Qiaoqiao XiaoXiao and J. Liang contributed equally to this article. …

Assessment of different CFD modeling and solving approaches for a supersonic steam ejector simulation

J Xiao, Q Wu, L Chen, W Ke, C Wu, X Yang, L Yu… - Atmosphere, 2022 - mdpi.com
The effects of different modeling and solving approaches on the simulation of a steam ejector
have been investigated with the computational fluid dynamics (CFD) technique. The four …

SHROOM2 inhibits tumor metastasis through RhoA–ROCK pathway-dependent and-independent mechanisms in nasopharyngeal carcinoma

J Yuan, L Chen, J Xiao, XK Qi, J Zhang, X Li… - Cell death & …, 2019 - nature.com
SHROOM2 is a key mediator of RhoA–ROCK pathway that regulates cell motility and actin
cytoskeleton organization. However, the functions of SHROOM2 beyond RhoA/ROCK …

The ubiquitin E3 ligase parkin inhibits innate antiviral immunity through K48-linked polyubiquitination of RIG-I and MDA5

L Bu, H Wang, P Hou, S Guo, M He, J Xiao… - Frontiers in …, 2020 - frontiersin.org
Innate immunity is the first-line defense against antiviral or antimicrobial infection. RIG-I and
MDA5, which mediate the recognition of pathogen-derived nucleic acids, are essential for …

A spatiotemporal molecular atlas of mouse spinal cord injury identifies a distinct astrocyte subpopulation and therapeutic potential of IGFBP2

…, Z Li, T Luan, G Cui, S Shu, Y Liang, K Zhang, J Xiao… - Developmental Cell, 2024 - cell.com
Spinal cord injury (SCI) triggers a cascade of intricate molecular and cellular changes that
determine the outcome. In this study, we resolve the spatiotemporal organization of the injured …

The RNA polymerase of cytoplasmically replicating Zika virus binds with chromatin DNA in nuclei and regulates host gene transcription

…, N Wang, M Luo, L Guo, J Xiao… - Proceedings of the …, 2022 - National Acad Sciences
Zika virus (ZIKV) targets the neural progenitor cells (NPCs) in brain during intrauterine
infections and consequently causes severe neurological disorders, such as microcephaly in …

Modulating the tumor microenvironment via oncolytic virus and PI3K inhibition synergistically restores immune checkpoint therapy response in PTEN-deficient …

F Xing, J Xiao, J Wu, J Liang, X Lu, L Guo, P Li… - Signal transduction and …, 2021 - nature.com
Glioblastoma (GBM) is a lethal primary brain cancer, with a median survival of less than 2
years. 1 Immune checkpoint blockades (ICBs) have revolutionized cancer therapy in the last …

Annealing enhanced optical performances of nano-multilayered TiAlN/AlCrSiN-based solar selective absorber

Q Wu, Z Wang, J Xiao, H Zhuang, T Huang… - Surface and Coatings …, 2023 - Elsevier
Solar selective absorber is an important component to improve the solar thermal conversion
efficiency of next-generation concentrated solar power with working temperature higher …

Digital twin-driven prognostics and health management for industrial assets

B Xiao, J Zhong, X Bao, L Chen, J Bao, Y Zheng - Scientific Reports, 2024 - nature.com
As a facilitator of smart upgrading, digital twin (DT) is emerging as a driving force in
prognostics and health management (PHM). Faults can lead to degradation or malfunction of …

Preparation and antioxidant properties of tannic acid/copper ion nanozyme hybrid nanofibrous membranes

Q Wu, J Xiao, H Zhuang, F Zhao, R Li, D Zhang - RSC advances, 2024 - pubs.rsc.org
Excess free radicals can have some negative effects on human health. In this paper, a
nanozyme was successfully constructed by the coordination of copper ions and tannic acid, and …